Multivalent vaccines for invasive Salmonella disease: need, rationale, and immunological foundations [0.03%]
多价疫苗预防侵袭性沙门氏菌病：需求、原理和免疫学基础
Pietro Mastroeni,Omar Rossi,Francesca Micoli
Pietro Mastroeni
Salmonella enterica infections are a major cause of morbidity and mortality worldwide, especially in sub-Saharan Africa and in the Asian continent, and are increasingly associated with antimicrobial resistance. Salmonella enterica serovars ...
Intralysosomal pathogens differentially influence the proteolytic potential of their niche [0.03%]
胞内病原体不同地影响其生存空间的蛋白水解潜能
Lauren E Bird,Bangyan Xu,David R Thomas et al.
Lauren E Bird et al.
Avoiding lysosomal degradation is vital to the success of intracellular pathogens. The Gram-negative bacterium Coxiella burnetii and protozoan parasites of the Leishmania genus are unique in being able to replicate within the mature phagoly...
Human body temperature cues widespread changes in virulence gene expression in uropathogenic Escherichia coli [0.03%]
人体温度诱导尿路致病性大肠杆菌毒力基因表达广泛变化
Carolyn A Dehner,Isidora N Stankovic,Madeleine Sutherland et al.
Carolyn A Dehner et al.
As a bacterial pathogen enters a human host, it immediately encounters a temperature upshift to 37°C. Mimicking the early hours of infection, we analyzed the transcriptome and proteome of uropathogenic Escherichia coli CFT073 initially gro...
Adrienne R Kambouris,Jerod A Brammer,Gideon Wolf et al.
Adrienne R Kambouris et al.
In a non-lethal, 10% total body surface area, full-thickness flame mouse model, infections with Pseudomonas aeruginosa (PA) increased mortality post-burn, suggesting an impaired host immune response. The presence of a seroma beneath the bur...
Metal uptake systems underpin Enterococcus faecalis virulence in both non-diabetic and diabetic wound infection models [0.03%]
金属吸收系统是肠球菌门粪肠球菌株在非糖尿病和糖尿病伤口感染模型中致病性的基础
Debra N Brunson,Ling Ning Lam,Shivani Kundra et al.
Debra N Brunson et al.
Wound infections remain an important medical problem, which is aggravated by the prevalence of multidrug-resistant bacteria. Among them, Enterococcus faecalis is a major pathogen of surgical site incisional and diabetic chronic wounds, but ...
Chlamydia trachomatis restricts signaling through NOD2 until late in the pathogen's developmental cycle [0.03%]
沙眼衣原体在感染晚期的发育周期中限制NOD2信号转导通路
Grace Overman,Iris Loeckener,Zachary Williford et al.
Grace Overman et al.
Pathogenic chlamydial species restrict their peptidoglycan (PG) to the division septum of their replicative forms. PG is a microbe-associated molecular pattern, and two of its major pattern recognition receptors in human cells are nucleotid...
Enterococcus faecalis persists and replicates intracellularly within neutrophils [0.03%]
粪肠球菌在中性粒细胞内持续存在并复制
Claudia J Stocks,Ronni A G da Silva,Haris Antypas et al.
Claudia J Stocks et al.
Chronic wound infection is a major global public health issue, with Enterococcus faecalis among the most commonly isolated pathogens from such wounds. Neutrophils are short-lived immune cells critical for host defense, yet E. faecalis-neutr...
The maternal-infant microbiome axis as an epigenetic and immunometabolic orchestrator: redefining early-life programming and precision interventions for lifelong women's and children's health [0.03%]
母胎微生物轴作为表观遗传和免疫代谢的调控者：重新定义生命早期编程及精准干预措施以保障终身妇女和儿童健康
Arpita Mukherjee
Arpita Mukherjee
The maternal-infant microbiome axis represents a dynamic interface that shapes neonatal immune and metabolic development from the earliest stages of life. Microbial communities from the maternal gut, vaginal tract, and breast milk seed the ...
Echinococcus granulosus antigen B acts as an LPS-scavenging lipoprotein in vitro, preventing TLR4-mediated activation of dendritic cells [0.03%]
棘球蚴抗原B作为内毒素清除脂蛋白对抗TLR4介导的树突状细胞活化作用
S Lagos Magallanes,A Beasley Lomazzi,F Zamarreño et al.
S Lagos Magallanes et al.
Echinococcus granulosus sensu lato antigen B (EgAgB) is a major parasite lipoprotein, produced by the hydatid and released at the host-parasite interface. Accumulating evidence supports that EgAgB may exert immunomodulatory effects on myelo...
T6SS1 suppresses pro-inflammatory cytokine transcription to drive immune evasion and systemic infection in Vibrio parahaemolyticus [0.03%]
天性毒素系统1通过抑制促炎细胞因子转录促进创伤弧菌免疫逃逸和全身感染
Shuqi Lu,Shuo Yuan,Pengxuan Liu et al.
Shuqi Lu et al.
The type VI secretion system (T6SS) is a major virulence factor in Vibrio parahaemolyticus, but its pathogenic mechanisms are poorly understood or still not fully understood. This study investigates how two critical T6SS1 structural compone...