CpoS-Inc interactions facilitate host cell modulation during Chlamydia trachomatis infection [0.03%]
感染沙眼衣原体期间CpoS-INC相互作用可促进宿主细胞调控
Xavier Tijerina,C A Jabeena,Robert Faris et al.
Xavier Tijerina et al.
Chlamydia trachomatis (C.t.), the leading bacterial cause of sexually transmitted infections, replicates within a unique intracellular compartment called the inclusion, which is modified by secreted proteins known as inclusion membrane (Inc...
Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection [0.03%]
补体C3缺乏增强慢性钩端螺旋体感染的肾脏菌血症和炎症并抑制T细胞分化
Leonardo Moura Midon,Amaro Nunes Duarte Neto,Ana Maria Gonçalves da Silva et al.
Leonardo Moura Midon et al.
Leptospirosis is a neglected disease caused by pathogenic Leptospira spp., affecting an estimated 1 million people annually and resulting in approximately 60,000 deaths. The disease can lead to hepatic, renal, and pulmonary dysfunctions and...
N-acetylchitohexaose confers resistance to Pseudomonas aeruginosa infection in the silkworm, Bombyx mori [0.03%]
N-乙酰壳六糖使家蚕（Bombyx mori）获得对绿脓杆菌的抗性
Kazuhiro Mikami,Hiroto Nakajima,Masaki Ishii et al.
Kazuhiro Mikami et al.
Lysin motif (LysM) domain-containing receptors are evolutionarily conserved pattern recognition receptors (PRRs) that serve as key mediators of glycan sensing and innate immune activation in plants and mammals. In invertebrates, however, th...
Recent progress in enterotoxigenic Escherichia coli vaccine research and development [0.03%]
近期肠毒素型大肠杆菌疫苗研发进展
Weiping Zhang,David A Sack
Weiping Zhang
There are no licensed vaccines against enterotoxigenic Escherichia coli (ETEC), a group of E. coli strains that produce a heat-labile toxin and/or a heat-stable toxin (STa). ETEC is one of the top four leading causes of diarrhea in children...
Control of human Q fever by vaccination: the journey to Q-VAX and beyond [0.03%]
人类Q热的疫苗预防：从Q-VAX到未来
Robert A Heinzen,Kathleen N Pierce,Daniel E Voth et al.
Robert A Heinzen et al.
Current vaccine development efforts encompass diverse and innovative approaches; however, studies with basic vaccines (e.g., whole cell inactivated) continue to inform these efforts. Perhaps the world's most effective and durable human vacc...
The GPCR NMUR-1 mediates neural regulation of energy homeostasis in response to pathogen infection [0.03%]
支配能量平衡的神经在病原体感染时通过GPCR NMUR-1介导调控作用
Phillip Wibisono,Yiyong Liu,Kenneth P Roberts et al.
Phillip Wibisono et al.
A key challenge in immunology is understanding how the innate immune system achieves specificity against diverse pathogens. Our previous work in Caenorhabditis elegans identified NMUR-1, a neuronal G protein-coupled receptor homologous to m...
Klebsiella pneumoniae ghosts as a novel adjuvant drive dendritic cell maturation and antigen-specific TCM expansion for IFN-γ-mediated immune protection [0.03%]
Klebsiella 肺炎克雷伯氏菌幽灵作为新型佐剂驱动树突状细胞成熟和抗原特异性 TCM 扩增以介导免疫保护的干扰素-γ的作用
Zhongtian Zhu,Junchi Xu,Jie Yang et al.
Zhongtian Zhu et al.
Klebsiella pneumoniae (K. pneumoniae), a common nosocomial pathogen causing severe pulmonary infections, is often complicated by coinfections. Bacterial ghosts, which are empty bacterial cell envelopes, hold significant promise as vaccine a...
VAR2CSA-reactive IgG in Brazilian women exposed to Plasmodium falciparum or P. vivax infection during pregnancy [0.03%]
巴西亚马孙地区怀孕期间感染恶性疟或间日疟的孕妇外周血单个核细胞产生的以VAR2CSA为靶标的IgG抗体
Maria Inês Dos Santos,Jamille Gregório Dombrowski,Henriette Hoffmann-Veltung et al.
Maria Inês Dos Santos et al.
Placental malaria (PM) causes mortality and severe morbidity in areas with stable Plasmodium falciparum transmission. The selective placental accumulation of P. falciparum-infected erythrocytes (IEs) is mediated by VAR2CSA, a PfEMP1-type pa...
Rickettsia rickettsii inactivated whole cell antigen vaccine protects against Rocky Mountain spotted fever independent of the adjuvant used [0.03%]
全灭活细胞疫苗可保护落基山斑点热病不受佐剂的影响
Perle Latré de Laté,Ian M Stoll,Jonathan Ferm et al.
Perle Latré de Laté et al.
Rocky Mountain spotted fever (RMSF) caused by Rickettsia rickettsii is the most fatal tick-borne disease in people and dogs in the Americas. This pathogen is transmitted by several hard ticks: Dermacentor species, Rhipicephalus sanguineus, ...
Lectin-Fc(IgG) fusion proteins exhibit antifungal activity against the emerging multidrug-resistant pathogen Candida auris [0.03%]
凝集素-Fc（IgG）融合蛋白对新兴的多重耐药病原体耳念珠菌具有抗真菌活性
Susana Ruiz Mendoza,Leandro Honorato,Deborah Santos Cintra et al.
Susana Ruiz Mendoza et al.
Candida auris is an emerging fungal pathogen recognized among the Centers for Disease Control and Prevention's urgent threats and designated a critical priority by the World Health Organization due to its global spread, high mortality rates...