Commensal resilience: ancient ecological lessons for the modern microbiota [0.03%]
互利共生的韧性：古代生态学对现代微生物群的启示
Abigail E Rose,Ryan T Fansler,Wenhan Zhu
Abigail E Rose
The gut microbiota constitutes a complex ecosystem essential for host health, offering metabolic support, modulating the immune system, and protecting against pathogens. However, this community faces constant destabilizing challenges, inclu...
STING contributes to the inflammation and proliferation of Staphylococcus aureus via mitochondrial reactive oxygen species-hypoxic inducible factor 1α axis in epithelial cells [0.03%]
STING通过线粒体活性氧-HIF-1α轴促进表皮细胞中金黄色葡萄球菌的炎症和增殖
Xing Gao,Binfeng Wu,Yawei Qiu et al.
Xing Gao et al.
Staphylococcus aureus infection poses a serious threat to the dairy industry and public health safety. The stimulator of interferon gene (STING) signaling pathway has been well established as effective in defending against viral infections....
Colonization dynamics of Streptococcus pneumoniae are determined by polymorphisms in the BlpAB transporter [0.03%]
链球菌定植动力学由BlpAB转运蛋白多态性决定
Surya D Aggarwal,Jacqueline Toussaint,John A Lees et al.
Surya D Aggarwal et al.
Colonization of the human airways, the first step in the pathogenesis of Streptococcus pneumoniae (Spn), is the determining factor in the ecological spread of the bacterium. Since co-colonization by multiple strains is common, within-host b...
Transdifferentiation of neutrophils facilitates the establishment of infection by Leishmania donovani parasites [0.03%]
中性粒细胞的重命途分化有利于唐氏利什曼原虫感染的建立
Madhurima Roy,Aniruddha Bagchi,Chaitali Karmakar et al.
Madhurima Roy et al.
Neutrophil transdifferentiation involves the acquisition of dendritic cell-like properties, challenging the traditional view of neutrophils being solely phagocytes. The presence of transdifferentiated neutrophils is established in Visceral ...
Parenteral vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization [0.03%]
重组EtpA糖蛋白的肌肉注射疫苗可降低产肠毒素大肠杆菌定植
Tim J Vickers,David P Buckley,Nazia Khatoon et al.
Tim J Vickers et al.
Enterotoxigenic E. coli (ETEC) causes hundreds of millions of cases of acute diarrheal illness in low- and middle-income regions, disproportionately in young children. To date, there is no licensed, broadly protective vaccine against these ...
Insights on the regulation and function of the CRISPR/Cas transposition system located in the pathogenicity island VpaI-7 from Vibrio parahaemolyticus RIMD2210633 [0.03%]
肠炎弧菌RIMD2210633中位于致病岛VpaI-7的CRISPR/Cas转座系统的调控与功能初探
Jesús E Alejandre-Sixtos,Kebia Aguirre-Martínez,Jessica Cruz-López et al.
Jesús E Alejandre-Sixtos et al.
CRISPR/Cas-mediated transposition is a recently recognized strategy for horizontal gene transfer in a variety of bacterial species. However, our understanding of the factors that control their function in their natural hosts is still limite...
Ayano Kuriu,Kazuya Ishikawa,Kohsuke Tsuchiya et al.
Ayano Kuriu et al.
Animal infection models are essential for understanding bacterial pathogenicity and corresponding host immune responses. In this study, we investigated whether juvenile Xenopus laevis could be used as an infection model for human pathogenic...
Phosphatidylserine-binding receptor, CD300f, on macrophages mediates host invasion of pathogenic and non-pathogenic rickettsiae [0.03%]
巨噬细胞上的磷脂酰丝氨酸结合受体CD300f介导立克次氏体对宿主的侵染作用
Oliver H Voss,Imran Moin,Hodalis Gaytan et al.
Oliver H Voss et al.
Some arthropod-borne obligate intracellular rickettsiae are among the most virulent human pathogens. Rickettsia species modulate immune (e.g., macrophages; MΦ) and non-immune cell (e.g., endothelial cells) responses to create a habitable e...
Evidence for a model of conformational change by the Plasmodium falciparum circumsporozoite protein during sporozoite development in the mosquito host through the use of camelid single-domain antibodies [0.03%]
通过使用骆驼单域抗体对受染蚊宿主体内按蚊周期毕氏疟原虫环子孢子蛋白构象变化模型的证据进行验证
Rob Geens,Line De Vocht,Manuela C Aguirre-Botero et al.
Rob Geens et al.
Plasmodium sporozoites (SPZs) are formed in the Anopheles mosquito midgut from where they travel to the salivary glands and subsequently to the mammalian liver after deposition into the skin. The SPZ's main surface antigen, the circumsporoz...
MBOVJF4278_00820 encodes a novel cytoadhesin of Mycoplasma bovis binding to heparin [0.03%]
MBOVJF4278_00820 编码一种与肝素结合的支原体新型细胞黏附分子
Qi Wu,Zhixin Ma,Qiao Pan et al.
Qi Wu et al.
Mycoplasma bovis, a minimal bacterium but a notorious cattle pathogen, leads to serious economic losses. This pathogen binding to host cells is emerging as a complex process involving a broad range of surface-exposed structures. For mycopla...