Heat Shock Proteins as the Druggable Targets in Leishmaniasis: Promises and Perils [0.03%]
热休克蛋白作为利什曼病的药物靶点：前景与挑战
Pragya Prasanna,Arun Upadhyay
Pragya Prasanna
Leishmania, the causative agent of leishmaniasis, is an intracellular pathogen that thrives in the insect gut and mammalian macrophages to complete its life cycle. Apart from temperature difference (26 to 37°C), it encounters several harsh...
Chlamydia-Specific IgA Secretion in the Female Reproductive Tract Induced via Per-Oral Immunization Confers Protection against Primary Chlamydia Challenge [0.03%]
口服免疫诱导的女性生殖道沙眼衣原体特异性IgA分泌对初次感染具有保护作用
Nita Shillova,Savannah E Howe,Besmir Hyseni et al.
Nita Shillova et al.
Chlamydia trachomatis is an obligate intracellular pathogen that causes sexually transmitted disease. In women, chlamydial infections may cause pelvic inflammatory disease (PID), ectopic pregnancy, and infertility. The role of antibodies in...
Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice [0.03%]
缺IL-8R2的小鼠比对照小鼠对肺类球孢子菌病的抵抗力更强
Aaron F Carlin,Suganya Viriyakosol,Sharon Okamoto et al.
Aaron F Carlin et al.
The pathology of human coccidioidomycosis is granulomatous inflammation with many neutrophils surrounding ruptured spherules, but the chemotactic pathways that draw neutrophils into the infected tissues are not known. We previously showed t...
Competing Substrates for the Bifunctional Diaminopimelic Acid Epimerase/Glutamate Racemase Modulate Peptidoglycan Synthesis in Chlamydia trachomatis [0.03%]
参与竞争的底物调节沙眼衣原体肽聚糖合成 диаминопимеловая酸双功能差向异构酶/谷氨酸 racemase 在沙眼衣原体中调控肽聚糖合成
Raghuveer Singh,Jessica A Slade,Mary Brockett et al.
Raghuveer Singh et al.
The Chlamydia trachomatis genome encodes multiple bifunctional enzymes, such as DapF, which is capable of both diaminopimelic acid (DAP) epimerase and glutamate racemase activity. Our previous work demonstrated the bifunctional activity of ...
Effects of Myeloid Hif-1β Deletion on the Intestinal Microbiota in Mice under Environmental Hypoxia [0.03%]
缺氧环境下髓系Hif-1β基因缺失对小鼠肠道菌群的影响
Ni Han,Zhiyuan Pan,Zongyu Huang et al.
Ni Han et al.
External environmental factors can cause an imbalance in intestinal flora. For people living in the extremes of a plateau climate, lack of oxygen is a primary health challenge that leads to a series of reactions. We wondered how intestinal ...
Burkholderia pseudomallei as an Enteric Pathogen: Identification of Virulence Factors Mediating Gastrointestinal Infection [0.03%]
作为肠道病原菌的伯克霍尔德菌假马来疫霉：鉴定调节肠道感染的毒力因子
Javier I Sanchez-Villamil,Daniel Tapia,Grace I Borlee et al.
Javier I Sanchez-Villamil et al.
Burkholderia pseudomallei is a Gram-negative bacterium and the causative agent of melioidosis. Despite advances in our understanding of the disease, B. pseudomallei poses a significant health risk, especially in regions of endemicity, where...
Exogenous Reproductive Hormones nor Candida albicans Colonization Alter the Near Neutral Mouse Vaginal pH [0.03%]
外来生殖激素或白色念珠菌定植不会改变近中性的小鼠阴道pH值
Jian Miao,Hubertine M E Willems,Brian M Peters
Jian Miao
While human vaginal pH in childbearing-age women is conclusively acidic, the mouse vaginal pH is reported as being near neutral. However, this information appears to be somewhat anecdotal with respect to vulvovaginal candidiasis, as such cl...
Antibody Opsonization Enhances Early Interactions between Yersinia pestis and Neutrophils in the Skin and Draining Lymph Node in a Mouse Model of Bubonic Plague [0.03%]
抗体介导的调理作用提高了鼠疫耶尔森菌在鼠模型皮肤和引流淋巴结中与中性粒细胞之间的早期相互作用
Jeffrey G Shannon,B Joseph Hinnebusch
Jeffrey G Shannon
Bubonic plague results when Yersinia pestis is deposited in the skin via the bite of an infected flea. Bacteria then traffic to the draining lymph node (dLN) where they replicate to large numbers. Without treatment, this infection can resul...
Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages [0.03%]
树突状细胞和巨噬细胞中通过Toll样受体2-Tpl2依赖的ERK信号通路驱动的相反的白介素12调控机制
Sarah G Groft,Nancy Nagy,W Henry Boom et al.
Sarah G Groft et al.
This study investigated responses to Toll-like receptor 2 (TLR2)-driven extracellular signal-related kinase (ERK) signaling in dendritic cells (DCs) versus macrophages. TLR2 signaling was induced with Pam3Cys-Ser-Lys4, and the role of ERK s...
Lactic Acid Supplementation Increases Quantity and Quality of Gametocytes in Plasmodium falciparum Culture [0.03%]
乳酸补充剂增加恶性疟原虫培养中的配子体的数量和质量
Rachel West,David J Sullivan
Rachel West
Malaria infection by Plasmodium falciparum continues to afflict millions of people worldwide, with transmission being dependent upon mosquito ingestion of the parasite gametocyte stage. These sexually committed stages develop from the asexu...