Microbial dysbiosis and associated disease mechanisms in maternal and child health [0.03%]
母儿健康中的微生物菌群失调及其相关疾病机制研究进展
Umer Ahmed,Furrmein Fatima,Hafiza Amna Farooq
Umer Ahmed
Maternal and infant microbiome dysbiosis is associated with poor health outcomes-gut, vaginal, and placental microbiome disruptions in the gut, vaginal, and potentially placental microbiomes-though the existence of a distinct placental micr...
Targeting anemia-induced CD71+ reticulocytes protects mice from Plasmodium infection [0.03%]
靶向治疗贫血诱导的CD71阳性网织红细胞可保护小鼠免受疟原虫感染
Sareh Zeydabadinejad,Jong Sung Anthony Kim,Anna Zheng et al.
Sareh Zeydabadinejad et al.
Malaria, caused by Plasmodium spp., is a global health concern linked to anemia and increased mortality. Compensatory erythropoiesis seen during acute anemia results in an increased circulating reticulocyte count (i.e., immature RBC), a key...
Clostridioides difficile toxins alter host metabolic pathway and bile acid homeostasis gene expression in colonic epithelium [0.03%]
艰难梭菌毒素改变结肠上皮细胞代谢途径和胆汁酸稳态基因的表达
Stephanie A Thomas,Colleen M Pike,Cypress E Perkins et al.
Stephanie A Thomas et al.
A major risk factor for acquiring Clostridioides difficile is antibiotic usage that disrupts a healthy microbial gut community, facilitating the establishment of infection. Once established, C. difficile secretes exotoxins (TcdA and TcdB) t...
Bioluminescent imaging to investigate Coxiella burnetii pathogenesis identifies adipose tissue as a host niche for infection [0.03%]
发光成像技术揭示了柯克斯体病原学识别脂肪组织作为感染宿主的生存环境
Jenna M Andrews,Craig R Roy
Jenna M Andrews
Coxiella burnetii is a gram-negative, obligate intracellular pathogen that causes Q fever in humans. In vivo research on C. burnetii is limited due to the classification of the Nine Mile phase I (NMI) strain as a select agent that requires ...
Live fast, die young: neutrophils streamline their metabolism to maximize inflammation [0.03%]
活得快死得早：中性粒细胞通过优化代谢反应以最大限度地提高炎症反应
Bailey E Holder,Callista P Reber,Andrew J Monteith
Bailey E Holder
Neutrophils are the most abundant leukocytes at sites of inflammation and form the front line of the innate immune response. Neutrophils have a relatively short lifespan compared to other cell types, as they have streamlined their metabolic...
Xingxing Yuan,Jiawei Gao,Ousman Bajinka et al.
Xingxing Yuan et al.
The joy of every mother is to survive a healthy pregnancy and give birth to a healthy baby. However, until today, many couples are finding it difficult to welcome a baby. Among the factors that cause infertility and recurrent pregnancy loss...
Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model [0.03%]
恒河猴模型中结核病复发的正电子发射断层扫描-计算机体层摄影表现及细菌播散特征
Pauline Maiello,Collin Diedrich,Tara Rutledge et al.
Pauline Maiello et al.
Tuberculosis (TB) relapse after appropriate drug treatment is poorly understood but critical to developing shorter treatment regimens. Using a cynomolgus macaque model of human TB, macaques with active TB disease were treated with a short c...
New insights into the life cycle, host cell tropism, and infection amplification of Leishmania spp [0.03%]
利什曼原虫生活史、宿主细胞嗜性及感染扩增的新见解
Anna Luiza Silva-Moreira,Artur Metzker Serravite,Laura Valéria Rios-Barros et al.
Anna Luiza Silva-Moreira et al.
The genus Leishmania comprises several species of digenetic protozoan parasites that cause a spectrum of diseases known as leishmaniases, which are transmitted to humans and other mammals through the bite of hematophagous female sand flies....
A chronic Pseudomonas aeruginosa mouse lung infection modeling the mucus obstruction, lung function, and inflammation of human cystic fibrosis [0.03%]
利用小鼠肺部感染绿脓杆菌模型模拟人类囊性纤维化患者黏液堵塞、肺功能及炎症症状
Mylene Vaillancourt,Sheryl E Fernandes,Diane Aguilar et al.
Mylene Vaillancourt et al.
Mouse models of cystic fibrosis (CF) have been used to study chronic lung infections; however, these models have lacked the airway mucus that defines human CF pathophysiology and required the use of mucoid Pseudomonas aeruginosa. Alternativ...
Proteomic profiling reveals immunomodulatory role of IL-33 in ocular bacterial and fungal infections [0.03%]
蛋白组学分析揭示IL-33在眼部细菌和真菌感染中的免疫调节作用
Zeeshan Ahmad,Sukhvinder Singh,Dhanwini Rudraprasad et al.
Zeeshan Ahmad et al.
Bacterial and fungal pathogens are major causes of infectious endophthalmitis following eye surgery or trauma, often leading to vision impairment or blindness. The distinct clinical outcomes observed in bacterial and fungal endophthalmitis ...