Differentiating Peromyscus leucopus bone marrow-derived macrophages for characterization of responses to Borrelia burgdorferi and lipopolysaccharide [0.03%]
利用脂多糖和伯氏疏螺旋体分化白足鼠骨髓来源的巨噬细胞以表征其反应类型
Christopher C Wells,Tanja Petnicki-Ocwieja,Shumin Tan et al.
Christopher C Wells et al.
Currently, most tools utilized in host-pathogen interaction studies depend on the use of human or mouse (Mus musculus) cells and tissues. While these species have led to countless breakthroughs in our understanding of infectious disease, th...
Augmented insights and minor adjustments to the role of adhesin proteins in Acinetobacter baumannii infections [0.03%]
关于粘附素蛋白在鲍曼不动杆菌感染中作用的见解和微调
Dongmei Xiao,Huaichang Zhong,Qionghua Huang et al.
Dongmei Xiao et al.
Infectivity of a pathogenicity-attenuated Chlamydia muridarum mutant in the genital tract [0.03%]
减毒肺炎衣原体突变株的生殖道感染性研究
Caiting Li,Zhaoyang Liu,Yaoqin Hua et al.
Caiting Li et al.
A Chlamydia muridarum mutant designated as intrOv was evaluated as an intracellular oral vaccine vector because it can induce protection in the genital tract following oral inoculation but does not elicit genital pathology following intrava...
Acquisition of daptomycin resistance in patients results in decreased virulence in Drosophila [0.03%]
患者达托霉素耐药菌的获得减少了果蝇中的毒力
Brigitte Lamy,Frédéric Laurent,Carolina J Simoes Da Silva et al.
Brigitte Lamy et al.
Staphylococcus aureus can acquire antimicrobial resistance, which in turn may affect its pathogenic potential. Using a panel of paired clinical isolates collected before and after daptomycin resistance acquisition, most frequently through a...
Maternal transfer of oral vaccine induced anti-OspA antibodies protects Peromyscus spp. from tick-transmitted Borrelia burgdorferi [0.03%]
母体转移口服疫苗诱导的抗OspA抗体可保护鼠类免受由蜱传播的伯氏疏螺旋体感染
Jose F Azevedo,Greg Joyner,Suman Kundu et al.
Jose F Azevedo et al.
The efficacy and duration of passive immunity protection depend on maternal antibody levels and transfer efficiency. We investigated whether oral vaccination of Peromyscus leucopus dams with recombinant outer surface protein A (OspA)-expres...
Commensal resilience: ancient ecological lessons for the modern microbiota [0.03%]
互利共生的韧性：古代生态学对现代微生物群的启示
Abigail E Rose,Ryan T Fansler,Wenhan Zhu
Abigail E Rose
The gut microbiota constitutes a complex ecosystem essential for host health, offering metabolic support, modulating the immune system, and protecting against pathogens. However, this community faces constant destabilizing challenges, inclu...
STING contributes to the inflammation and proliferation of Staphylococcus aureus via mitochondrial reactive oxygen species-hypoxic inducible factor 1α axis in epithelial cells [0.03%]
STING通过线粒体活性氧-HIF-1α轴促进表皮细胞中金黄色葡萄球菌的炎症和增殖
Xing Gao,Binfeng Wu,Yawei Qiu et al.
Xing Gao et al.
Staphylococcus aureus infection poses a serious threat to the dairy industry and public health safety. The stimulator of interferon gene (STING) signaling pathway has been well established as effective in defending against viral infections....
Colonization dynamics of Streptococcus pneumoniae are determined by polymorphisms in the BlpAB transporter [0.03%]
链球菌定植动力学由BlpAB转运蛋白多态性决定
Surya D Aggarwal,Jacqueline Toussaint,John A Lees et al.
Surya D Aggarwal et al.
Colonization of the human airways, the first step in the pathogenesis of Streptococcus pneumoniae (Spn), is the determining factor in the ecological spread of the bacterium. Since co-colonization by multiple strains is common, within-host b...
Transdifferentiation of neutrophils facilitates the establishment of infection by Leishmania donovani parasites [0.03%]
中性粒细胞的重命途分化有利于唐氏利什曼原虫感染的建立
Madhurima Roy,Aniruddha Bagchi,Chaitali Karmakar et al.
Madhurima Roy et al.
Neutrophil transdifferentiation involves the acquisition of dendritic cell-like properties, challenging the traditional view of neutrophils being solely phagocytes. The presence of transdifferentiated neutrophils is established in Visceral ...
Parenteral vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization [0.03%]
重组EtpA糖蛋白的肌肉注射疫苗可降低产肠毒素大肠杆菌定植
Tim J Vickers,David P Buckley,Nazia Khatoon et al.
Tim J Vickers et al.
Enterotoxigenic E. coli (ETEC) causes hundreds of millions of cases of acute diarrheal illness in low- and middle-income regions, disproportionately in young children. To date, there is no licensed, broadly protective vaccine against these ...