Non-receptor tyrosine kinase c-Abl downstream of C-type lectin receptors regulates innate antifungal immunity through c-Cbl/MAPK pathway [0.03%]
C型凝集素受体下游非受体酪氨酸激酶c-Abl通过c-Cbl/MAPK通路调节先天抗真菌免疫反应
Shu-Jun Ma,Ke-Fang Xie,Jie-Lin Duan et al.
Shu-Jun Ma et al.
Non-receptor tyrosine kinase c-Abl is critical for host defense against bacterial and viral infections, yet its role in antifungal immunity remains elusive. Here, we report that inhibition of c-Abl with flumatinib mesylate significantly imp...
Spatial organization of Gardnerella species, Prevotella bivia, and Fannyhessea vaginae in the bacterial vaginosis biofilm [0.03%]
加德纳菌、Prevotella bivia 和 Fannyhessea vaginae 在细菌性阴道病生物膜中的空间组织
Sheridan D George,Megan H Amerson-Brown,Lúcia G V Sousa et al.
Sheridan D George et al.
Key bacterial vaginosis (BV)-associated bacteria implicated in biofilm formation include Gardnerella species, Prevotella bivia, and Fannyhessea vaginae. We investigated their spatial organization in the BV biofilm over time from longitudina...
Krista E van Meijgaarden,Patricia S Grace,Natalia T Freund et al.
Krista E van Meijgaarden et al.
The human immune system employs both innate and adaptive mechanisms to control pathogens, with antibodies playing a pivotal role in immune memory and defense, in particular against viral infections. In tuberculosis, antibody titers have lon...
mTORC1 inhibitors rapamycin and everolimus as host-directed therapy for tuberculosis [0.03%]
雷帕霉素和Everolimus作为结核病的宿主导向疗法中的mTORC1抑制剂
Robin H G A van den Biggelaar,Tom H M Ottenhoff
Robin H G A van den Biggelaar
Treponema pallidum's neural invasion: from blood-brain barrier breach to immune sabotage [0.03%]
苍白密螺旋体神经入侵：从破坏血脑屏障到免疫干扰
Han Yu,Sisi Zhao,Ke Yang et al.
Han Yu et al.
Neurosyphilis is an infectious disease of the nervous system caused by Treponema pallidum. With the resurgence of syphilis worldwide, neurosyphilis has become prevalent again, but research on its pathogenesis remains challenging. T. pallidu...
Dead but not gone: the interplay between the programmed cell death process and surrounding bacteria [0.03%]
死而不亡：细胞程序性死亡过程与周围细菌之间的相互作用
Sam Benson,Christopher J Anderson
Sam Benson
Cell death is an integral part of homeostasis, removing damaged and infected cells and replenishing healthy cells. It is a process well understood from a host perspective, with clearly delineated pathways and an expansive literature as to h...
Tracing the early bacterial settlers in preterm and very-low birth-weight infants: first report of microbiota dynamics in South American neonates [0.03%]
南美新生儿微生物组动态研究：早产和超低体重出生婴儿早期细菌定植规律研究报告
Josefina Vera,Catalina Vaz Ferreira,Mario Moraes et al.
Josefina Vera et al.
Mortality in very-low birth-weight (VLBW) infants accounts for up to 50%-70% of the neonatal mortality and up to 25%-30% of infant mortality. Despite the global increase in survival rates, this population remains at heightened risk for deve...
Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes [0.03%]
铜绿假单胞菌介导的伪帕林锌吸收诱导临床相关表型和感染结果
Lola Bosc,Thomas Sécher,Geneviève Ball et al.
Lola Bosc et al.
Biological metals are vital trace elements required by metalloproteins, which are involved in virtually every cellular, structural, and catalytic function of the bacterial cell. Bacterial pathogenesis involves a tug-of-war between the host'...
Olfactomedin-4+ neutrophils exacerbate intestinal epithelial damage in Clostridioides difficile infection [0.03%]
嗅觉医学蛋白4阳性中性粒细胞可加重艰难梭菌感染所致的肠上皮损伤
S Jose,A Huber,A Kassam et al.
S Jose et al.
Neutrophils are dominant cells during acute immune response to Clostridioides difficile infection (CDI). A higher number of infiltrating colonic neutrophils is clearly linked to greater tissue damage and severe CDI (3, 4). However, the mech...
Interactions between Streptococcus agalactiae and Candida albicans affect persistence and virulence [0.03%]
肠球菌与白念珠菌的相互作用会影响其持久性及致病性
Kathryn Patenaude,Chloe N Bossow,Anna Lane et al.
Kathryn Patenaude et al.
Streptococcus agalactiae (Group B Streptococcus or GBS), a Gram-positive bacterium, and Candida albicans, a polymorphic fungus, are commensal microbes in most of the population they colonize. However, for certain patients, they can cause se...