Tripartite motif 2b (trim2b) restricts spring viremia of carp virus by degrading viral proteins and negative regulators NLRP12-like receptors [0.03%]
三聚体基序蛋白2b通过降解病毒蛋白和NLRP12样受体限制鲤春病毒病病毒感染
Hong Fang,Xiao Man Wu,Si Yao Zheng et al.
Hong Fang et al.
Tripartite motif (TRIM) proteins are involved in different cellular functions, including regulating virus infection. In teleosts, two orthologous genes of mammalian TRIM2 are identified. However, the functions and molecular mechanisms of pi...
Nilabja Roy Chowdhury,Vyacheslav Gurevich,Meir Shamay
Nilabja Roy Chowdhury
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-herpesvirus family and is a well-known human oncogenic virus. In infected cells, the viral genome of 165 kbp is circular DNA wrapped in chromatin. The tight control of gene...
Pharmacological activation of TLR7 exerts inhibition on the replication of EV-D68 in respiratory cells [0.03%]
TLR7的药理学激活可抑制呼吸道细胞中EV-D68的复制
Huili Li,Yuehan Huang,Qingran Yang et al.
Huili Li et al.
The globally reemerging respiratory pathogen enterovirus D68 (EV-D68) is implicated in outbreaks of severe respiratory illness and associated with acute flaccid myelitis. However, there remains a lack of effective treatments for EV-D68 infe...
Novel insights into the host cell glycan binding profile of human metapneumovirus [0.03%]
人副流感病毒第六型糖蛋白与宿主细胞糖类结合的新见解
Annelies Van Den Bergh,Benjamin Bailly,Patrice Guillon et al.
Annelies Van Den Bergh et al.
Numerous viruses have been found to exploit glycoconjugates expressed on human cells as their initial attachment factor for viral entry and infection. The virus-cell glycointeractome, when characterized, may serve as a template for antivira...
Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate TLR4 signaling in immune cells [0.03%]
HIV-1病毒颗粒中的CD14使病毒能够结合LPS并激活免疫细胞中TLR4信号通路
Arvin T Persaud,Jasmin Khela,Claire Fernandes et al.
Arvin T Persaud et al.
HIV-1 has a broad range of nuanced interactions with the immune system, and the incorporation of cellular proteins by nascent virions continues to redefine our understanding of the virus-host relationship. Proteins located at the sites of v...
Correction for Samsa et al., "Uncoupling cis-Acting RNA Elements from Coding Sequences Revealed a Requirement of the N-Terminal Region of Dengue Virus Capsid Protein in Virus Particle Formation" [0.03%]
对Samsa等“解开编码序列的顺式作用RNA元件显示登革病毒衣壳蛋白N端区在病毒颗粒形成中的要求”的更正
Marcelo M Samsa,Juan A Mondotte,Julio J Caramelo et al.
Marcelo M Samsa et al.
Published Erratum
Journal of virology. 2024 May 14;98(5):e0052724. DOI:10.1128/jvi.00527-24 2024
Zhiwei Gu,Kexun Wu,Jiawei Wang
Zhiwei Gu
The portal protein of tailed bacteriophage plays essential roles in various aspects of capsid assembly, motor assembly, genome packaging, connector formation, and infection processes. After DNA packaging is complete, additional proteins are...
Japanese encephalitis virus NS1 and NS1' proteins induce vimentin rearrangement via the CDK1-PLK1 axis to promote viral replication [0.03%]
日本脑炎病毒NS1和NS1'蛋白通过CDK1-PLK1轴诱导波形蛋白重排以促进病毒复制
Shengda Xie,Xiaoxiao Yang,Xingmiao Yang et al.
Shengda Xie et al.
The host cytoskeleton plays crucial roles in various stages of virus infection, including viral entry, transport, replication, and release. However, the specific mechanisms by which intermediate filaments are involved in orthoflavivirus inf...
A dual fluorescent herpes simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection [0.03%]
一种双重荧光单纯疱疹病毒I型重组病毒揭示了神经元感染后产生的不同结果
Luke F Domanico,Gary P Dunn,Oren Kobiler et al.
Luke F Domanico et al.
Critical stages of lytic herpes simplex virus type 1 (HSV-1) replication are marked by the sequential expression of immediate early (IE) to early (E), then late (L) viral genes. HSV-1 can also persist in neuronal cells via a non-replicative...