Kaposi sarcoma-associated herpesvirus complement control protein (KCP) and glycoprotein K8.1 are not required for viral infection in vitro or in vivo [0.03%]
霍奇金病相关疱疹病毒补体控制蛋白(KCP)和糖蛋白K8.1不是体内外病毒感染所必需的
Murali Muniraju,Lorraine Z Mutsvunguma,Ivana G Reidel et al.
Murali Muniraju et al.
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, is the causal agent of Kaposi sarcoma, a cancer that appears as tumors on the skin or mucosal surfaces, as well as primary effusion lymphoma and KSHV-associate...
S309-CAR-NK cells bind the Omicron variants in vitro and reduce SARS-CoV-2 viral loads in humanized ACE2-NSG mice [0.03%]
S309-CAR-NK细胞在体外结合奥密克戎变异株，并降低人ACE2-NSG小鼠中的新冠病毒载量
Minh Tuyet Ma,Qingkui Jiang,Chih-Hsiung Chen et al.
Minh Tuyet Ma et al.
Recent progress on chimeric antigen receptor (CAR)-NK cells has shown promising results in treating CD19-positive lymphoid tumors with minimal toxicities [including graft versus host disease (GvHD) and cytokine release syndrome (CRS) in cli...
An mRNA-LNP-based Lassa virus vaccine induces protective immunity in mice [0.03%]
基于mRNA-LNP的拉沙病毒疫苗可诱导小鼠产生保护性免疫反应
Mei Hashizume,Ayako Takashima,Masaharu Iwasaki
Mei Hashizume
The mammarenavirus Lassa virus (LASV) causes the life-threatening hemorrhagic fever disease, Lassa fever. The lack of licensed medical countermeasures against LASV underscores the urgent need for the development of novel LASV vaccines, whic...
Classical swine fever virus non-structural protein 4A recruits dihydroorotate dehydrogenase to facilitate viral replication [0.03%]
经典猪瘟病毒非结构蛋白4A通过募集二氢乳清酸脱氢酶促进病毒复制
Bing-Qian Zhao,Jing Chen,Jin-Xia Chen et al.
Bing-Qian Zhao et al.
Mitochondria are energy producers in cells, which can affect viral replication by regulating the host innate immune signaling pathways, and the changes in their biological functions are inextricably linked the viral life cycle. In this stud...
Targeting host O-linked glycan biosynthesis affects Ebola virus replication efficiency and reveals differential GalNAc-T acceptor site preferences on the Ebola virus glycoprotein [0.03%]
靶向宿主O连接糖基生物合成会影响埃博拉病毒的复制效率并在埃博拉病毒糖蛋白上揭示了不同的GalNac-T接受位点偏好性
Ieva Bagdonaite,Samir Abdurahman,Mattia Mirandola et al.
Ieva Bagdonaite et al.
Ebola virus glycoprotein (EBOV GP) is one of the most heavily O-glycosylated viral glycoproteins, yet we still lack a fundamental understanding of the structure of its large O-glycosylated mucin-like domain and to what degree the host O-gly...
The genomic and phylogenetic analysis of Marseillevirus cajuinensis raises questions about the evolution of Marseilleviridae lineages and their taxonomical organization [0.03%]
麦萨尔病毒(cajuinensis)的基因组和系统发育分析使其进化及分类学地位存疑
Bruna Luiza de Azevedo,Victória Fulgêncio Queiroz,Isabella Luiza Martins de Aquino et al.
Bruna Luiza de Azevedo et al.
Marseilleviruses (MsV) are a group of viruses that compose the Marseilleviridae family within the Nucleocytoviricota phylum. They have been found in different samples, mainly in freshwater. MsV are classically organized into five phylogenet...
Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7 [0.03%]
人疱疹病毒8型病毒干扰素调节因子4与泛素特异性蛋白酶7的生物学意义相互作用
Zunlin Yang,John Nicholas
Zunlin Yang
Human herpesvirus 8 (HHV-8), associated with Kaposi sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman disease, encodes four interferon regulatory factor homologs, vIRFs 1-4, that interact with and inhibit various mediator...
Detection of clade 2.3.4.4b highly pathogenic H5N1 influenza virus in New York City [0.03%]
纽约市检出高致病性H5N1avianinfluenza2.3.4.4b分支病毒感染病例
Philip S Meade,Pooja Bandawane,Kaitlyn Bushfield et al.
Philip S Meade et al.
Highly pathogenic avian influenza viruses of the H5N1 clade 2.3.4.4b were detected in North America in the winter of 2021/2022. These viruses have spread across the Americas, causing morbidity and mortality in both wild and domestic birds a...
LINC08148 promotes the caveola-mediated endocytosis of Zika virus through upregulating transcription of Src [0.03%]
LINC08148通过上调Src的转录促进Zika病毒的网格蛋白独立内吞途径入侵宿主细胞
Zhiting Huo,Xuanfeng Zhu,Qinyu Peng et al.
Zhiting Huo et al.
Long non-coding RNAs (lncRNAs) represent a new group of host factors involved in viral infection. Current study identified an intergenic lncRNA, LINC08148, as a proviral factor of Zika virus (ZIKV) and Dengue virus 2 (DENV2). Knockout (KO) ...
Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CLpro main protease (Mpro) from proteomic identification of P6-P6' active site specificity [0.03%]
基于蛋白质组学鉴定的P6-P6'作用位点特异性优化荧光淬灭肽底物以筛选SARS-CoV-2 M(pro)抑制剂
Hugo Cesar Ramos de Jesus,Nestor Solis,Yoan Machado et al.
Hugo Cesar Ramos de Jesus et al.
SARS-CoV-2 3C-like main protease (3CLpro) is essential for protein excision from the viral polyprotein. 3CLpro inhibitor drug development to block SARS-CoV-2 replication focuses on the catalytic non-prime (P) side for specificity and potenc...