RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation [0.03%]
狂犬病毒通过调节Rac1活性诱导肌动蛋白细胞骨架的双向重排
Xiaomin Liu,Jing Xu,Maolin Zhang et al.
Xiaomin Liu et al.
Rabies virus (RABV) is highly lethal and triggers severe neurological symptoms. The neuropathogenic mechanism remains poorly understood. Ras-related C3 botulinum toxin substrate 1 (Rac1) is a Rho-GTPase that is involved in actin remodeling ...
Subgenomic flavivirus RNA as key target for live-attenuated vaccine development [0.03%]
亚基因组黄病毒RNA作为减毒活疫苗研发的关键靶点
Kristel Doets,Gorben P Pijlman
Kristel Doets
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses...
Correction for Domingo et al., "Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies" [0.03%]
对Domingo等人的“SARS-CoV-2准种的难题、挑战及信息库”的更正
Esteban Domingo,Brenda Martínez-González,Carlos García-Crespo et al.
Esteban Domingo et al.
Published Erratum
Journal of virology. 2024 Jun 13;98(6):e0026324. DOI:10.1128/jvi.00263-24 2024
Marissa Knoll,Rebekah Honce,Victoria Meliopoulos et al.
Marissa Knoll et al.
Obesity is well established as a risk factor for many noncommunicable diseases; however, its consequences for infectious disease are poorly understood. Here, we investigated the impact of host obesity on influenza A virus (IAV) genetic vari...
Vincenzo A Costa,Edward C Holmes
Vincenzo A Costa
The production of aquatic animals has more than doubled over the last 50 years and is anticipated to continually increase. While fish are recognized as a valuable and sustainable source of nutrition, particularly in the context of human pop...
Reverse transcription of HIV-1 2-LTR circle transcripts does frequently cause 3'-polypurine tract mutations implicated in dolutegravir resistance [0.03%]
HIV-1 2-长末端重复序列圈转录本的逆转录经常导致与多替拉韦耐药有关的3'-聚嘌呤tract突变
José G Dekker,Bep Klaver,Ben Berkhout et al.
José G Dekker et al.
Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response [0.03%]
干扰素反应限制了甲型流感病毒向小鼠下呼吸道的扩散
Lara S U Schwab,Thi H T Do,Devaki Pilapitiya et al.
Lara S U Schwab et al.
The global burden of disease caused by influenza B virus (IBV) is substantial; however, IBVs remain overlooked. Understanding host-pathogen interactions and establishing physiologically relevant models of infection are important for the dev...
SIV infection and ARV treatment reshape the transcriptional and epigenetic profile of naïve and memory T cells in vivo [0.03%]
人类HIV感染和抗逆转录病毒治疗重塑体内初始态和记忆T细胞的转录和表观遗传特征
Andrew R Rahmberg,Tovah E Markowitz,Joseph C Mudd et al.
Andrew R Rahmberg et al.
Human and simian immunodeficiency viruses (HIV and SIV) are lentiviruses that reverse transcribe their RNA genome with subsequent integration into the genome of the target cell. How progressive infection and administration of antiretroviral...
Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo [0.03%]
猪传染性胃肠炎病毒通过RIG-I/NF-κB/HIF-1α/糖酵解轴诱导类器官和活体炎症反应
Yunhang Zhang,Ning Yang,Yang Li et al.
Yunhang Zhang et al.
Transmissible gastroenteritis virus (TGEV)-induced enteritis is characterized by watery diarrhea, vomiting, and dehydration, and has high mortality in newborn piglets, resulting in significant economic losses in the pig industry worldwide. ...
Aberrant RNA polymerase initiation and processivity on the genome of a herpes simplex virus 1 mutant lacking ICP27 [0.03%]
缺失ICP27的单纯疱疹病毒1型突变体基因组上异常RNA聚合酶起始和延伸属性的研究
Claire H Birkenheuer,Joel D Baines
Claire H Birkenheuer
Within the first 15 minutes of infection, herpes simplex virus 1 immediate early proteins repurpose cellular RNA polymerase (Pol II) for viral transcription. An important role of the viral-infected cell protein 27 (ICP27) is to facilitate v...