Bile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition [0.03%]
胆酸敏感的人类诺如病毒株易受鞘氨醇-1-磷酸受体2抑制的影响
Victoria Tenge,B Vijayalakshmi Ayyar,Khalil Ettayebi et al.
Victoria Tenge et al.
Human noroviruses (HuNoVs) are a diverse group of RNA viruses that cause endemic and pandemic acute viral gastroenteritis. Previously, we reported that many HuNoV strains require bile or bile acid (BA) to infect human jejunal intestinal ent...
The HTLV-I oncoprotein Tax inactivates the tumor suppressor FBXW7 [0.03%]
人类T细胞白血病病毒I型癌蛋白Tax通过抑制肿瘤抑制因子FBXW7的活性诱导细胞转化
Marcia Bellon,Chien-Hung Yeh,Xue Tao Bai et al.
Marcia Bellon et al.
Human T-cell leukemia virus type 1 (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL). Mutational analysis has demonstrated that the tumor suppressor, F-box and WD repeat domain containing 7 (FBXW7/FBW7/CDC4), is mutated in pr...
Trimerized S expressed by modified vaccinia virus Ankara (MVA) confers superior protection against lethal SARS-CoV-2 challenge in mice [0.03%]
改良痘病毒安卡拉株（MVA）表达的三聚体S蛋白对小鼠提供更强的保护作用以抵抗致死量的SARS-CoV-2攻击
Junda Zhu,Zhenshan Wang,Yarui Li et al.
Junda Zhu et al.
The reoccurrence of successive waves of SARS-CoV-2 variants suggests the exploration of more vaccine alternatives is imperative. Modified vaccinia virus Ankara (MVA) is a virus vector exhibiting excellent safety as well as efficacy for vacc...
HPV-18 E6 enhances the interaction between EMILIN2 and SNX27 to promote WNT signaling [0.03%]
HPV-18 E6增强EMILIN2和SNX27的相互作用以促进WNT信号转导
Justyna Broniarczyk,Oscar Trejo-Cerro,Paola Massimi et al.
Justyna Broniarczyk et al.
Oncogenic HPV E6 proteins have a PDZ-binding motif (PBM) which plays important roles in both the viral life cycle and tumor development. The PBM confers interaction with a large number of different PDZ domain-containing substrates, one of w...
Impaired interferon response in senecavirus A infection and identification of 3Cpro as an antagonist [0.03%]
Senecavirus A感染的干扰素应答障碍及3Cpro拮抗剂的作用鉴定
Xiangle Zhang,Pengfei Li,Wenzhe Chen et al.
Xiangle Zhang et al.
Senecavirus A (SVA), a picornavirus, causes vesicular diseases and epidemic transient neonatal losses in swine, resulting in a multifaceted economic impact on the swine industry. SVA counteracts host antiviral response through multiple stra...
Deficiency in Ever2 does not increase susceptibility of mice to pathogenesis by the mouse papillomavirus, MmuPV1 [0.03%]
Ever2缺乏并不增加小鼠对小鼠乳头状瘤病毒MmuPV1感染的易感性
Alexandra D Torres,Renee E King,Aayushi Uberoi et al.
Alexandra D Torres et al.
Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder that is characterized by the development of papillomavirus-induced skin lesions that can progress to squamous cell carcinoma (SCC). Certain high-risk, cutaneous β-genus h...
Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation [0.03%]
单纯疱疹病毒1型VP16蛋白的神经元表达可诱导伪狂犬病病毒逃逸并重新激活
Zhi-Shan Hsu,Esteban A Engel,Lynn W Enquist et al.
Zhi-Shan Hsu et al.
Alpha herpesvirus (α-HV) particles enter their hosts from mucosal surfaces and efficiently maintain fast transport in peripheral nervous system (PNS) axons to establish infections in the peripheral ganglia. The path from axons to distant n...
Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria [0.03%]
共生呼吸道细菌增强了流感病毒在飞沫和气溶胶中的稳定性
Shannon C David,Aline Schaub,Céline Terrettaz et al.
Shannon C David et al.
Aerosol transmission remains a major challenge for control of respiratory viruses, particularly those causing recurrent epidemics, like influenza A virus (IAV). These viruses are rarely expelled alone, but instead are embedded in a consorti...
VP1 is the primary determinant of neuropathogenesis in a mouse model of enterovirus D68 acute flaccid myelitis [0.03%]
VP1是肠道病毒D68急性迟缓性麻痹小鼠模型中神经毒性的主要决定因素
J Smith Leser,Joshua L Frost,Courtney J Wilson et al.
J Smith Leser et al.
Enterovirus D68 (EV-D68) is an emerging pathogen that can cause severe respiratory and neurologic disease [acute flaccid myelitis (AFM)]. Intramuscular (IM) injection of neonatal Swiss Webster (SW) mice with US/IL/14-18952 (IL52), a clinica...
PA-824 inhibits porcine epidemic diarrhea virus infection in vivo and in vitro by inhibiting p53 activation [0.03%]
PA-824通过抑制p53激活来抑制猪流行性腹泻病毒感染的体内和体外研究
Liang Li,Hongyue Li,Yanping Qiu et al.
Liang Li et al.
Porcine epidemic diarrhea virus (PEDV) is a type A coronavirus that causes severe watery diarrhea in piglets, resulting in severe economic losses worldwide. Therefore, new approaches to control PEDV infection are essential for a robust and ...