The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting [0.03%]
干扰素调节的宿主因子hnRNPA0通过干扰LTR活性、mRNA运输和程序化核糖体frameshifting来调节HIV-1的产生
Fabian Roesmann,Helene Sertznig,Katleen Klaassen et al.
Fabian Roesmann et al.
The interplay between host factors and viral components impacts viral replication efficiency profoundly. Members of the cellular heterogeneous nuclear ribonucleoprotein family (hnRNPs) have been extensively studied as HIV-1 host dependency ...
Herpes simplex virus type-1 cVAC formation in neuronal cells is mediated by dynein motor function and glycoprotein retrieval from the plasma membrane [0.03%]
单纯疱疹病毒1型神经元细胞cVAC形成由动力蛋白马达功能和从胞浆膜回收糖蛋白介导
Shaowen White,Richard Roller
Shaowen White
Herpesvirus assembly requires the cytoplasmic association of large macromolecular and membrane structures that derive from both the nucleus and cytoplasmic membrane systems. Results from the study of human cytomegalovirus (HCMV) in cells wh...
Optimization of immunosuppression strategies for the establishment of chronic hepatitis E virus infection in rabbits [0.03%]
优化家兔慢性HEV感染免疫抑制方案的研究
Qiyu He,Tianxu Liu,Xinyue Yang et al.
Qiyu He et al.
Chronic hepatitis E mostly occurs in organ transplant recipients and can lead to rapid liver fibrosis and cirrhosis. Previous studies found that the development of chronic hepatitis E virus (HEV) infection is linked to the type of immunosup...
Involvement of ribosomal protein L17 and Y-box binding protein 1 in the assembly of hepatitis C virus potentially via their interaction with the 3' untranslated region of the viral genome [0.03%]
核糖体蛋白L17和Y-框结合蛋白1通过与HCV基因组3'非翻译区相互作用参与HCV装配
Jie Liu,Masahiko Ito,Liang Liu et al.
Jie Liu et al.
The 3' untranslated region (3'UTR) of the hepatitis C virus (HCV) RNA genome, which contains a highly conserved 3' region named the 3'X-tail, plays an essential role in RNA replication and promotes viral IRES-dependent translation. Although...
Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model [0.03%]
中和单克隆抗体针对新冠病毒的疗效在非人灵长类模型中的遗传屏障分析
Christiane Stahl-Hennig,Antonia Sophia Peter,Arne Cordsmeier et al.
Christiane Stahl-Hennig et al.
The potency of antibody neutralization in cell culture has been used as the key criterion for selection of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for clinical development. As other aspects may also i...
Transcription factor EB (TFEB) interaction with RagC is disrupted during enterovirus D68 infection [0.03%]
肠道病毒D68感染会破坏转录因子EB(TFEB)与拉格C的相互作用
Alagie Jassey,Noah Pollack,Michael A Wagner et al.
Alagie Jassey et al.
Enterovirus D68 (EV-D68) is a picornavirus associated with severe respiratory illness and a paralytic disease called acute flaccid myelitis in infants. Currently, no protective vaccines or antivirals are available to combat this virus. Like...
Infection and intracellular transport of white spot syndrome virus require the ESCRT machinery in shrimp [0.03%]
虾的白斑综合征病毒感染和细胞内运输需要端osomal Sorting Complex Required Transport (ESCRT) 机制
Li-Xia Lv,Jie Gao,Hao Wang et al.
Li-Xia Lv et al.
The cellular endosomal sorting complex required for transport (ESCRT) system comprises five distinct components and is involved in many different physiological processes. Recent studies have shown that different viruses rely upon the host E...
Bloodmeals fuel dengue virus replication in the female mosquito Aedes aegypti [0.03%]
雌黄热蚊Aedes aegypti通过吸取血液来促进登革病毒的复制
Yu-Ning Huang,Kuan-Ying Lee,Shin-Hong Shiao et al.
Yu-Ning Huang et al.
Vector competence defines the ability of a vector to acquire, host, and transmit a pathogen. Understanding the molecular determinants of the mosquitos' competence to host dengue virus (DENV) holds promise to prevent its transmission. To thi...
Mutations in nonstructural proteins essential for pathogenicity in SARS-CoV-2-infected mice [0.03%]
SARS-CoV-2感染小鼠中的非结构蛋白的致病性突变研究
Ruangang Pan,Pengfei Li,David K Meyerholz et al.
Ruangang Pan et al.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has resulted in substantial morbidity and mortality. The basis of severe disease in humans is difficult to determine without the use...
Nervous necrosis virus capsid protein and Protein A dynamically modulate the fish cGAS-mediated IFN signal pathway to facilitate viral evasion [0.03%]
神经坏死病毒衣壳蛋白和蛋白质A动态调节鱼cGAS介导的I型干扰素信号通路以促进病毒逃逸
Siyou Huang,Linwei Yang,Rui Zheng et al.
Siyou Huang et al.
Nervous necrosis virus (NNV), an aquatic RNA virus belonging to Betanodavirus, infects a variety of marine and freshwater fishes, leading to massive mortality of cultured larvae and juveniles and substantial economic losses. The enzyme cycl...