Dissecting infectious bronchitis virus-induced host shutoff at the translation level [0.03%]
从翻译水平分析传染性支气管炎病毒导致的宿主功能丧失现象
Jing Zhao,Yahui Huang,Chengyin Liukang et al.
Jing Zhao et al.
Viruses have evolved a range of strategies to utilize or manipulate the host's cellular translational machinery for efficient infection, although the mechanisms by which infectious bronchitis virus (IBV) manipulates the host translation mac...
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy [0.03%]
一种体外人源精密切片肺组织模型平台为SARS-CoV-2致病机制及抗病毒药物疗效提供研究视角
Roger D Pechous,Priyangi A Malaviarachchi,Srijon K Banerjee et al.
Roger D Pechous et al.
Coronavirus disease 2019 (COVID-19) has claimed millions of lives since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and lung disease appears the primary cause of death in COVID-19 patients. However, the un...
Transcriptome analysis of CpGV in midguts of type II resistant codling moth larvae and identification of contaminant infections by SNP mapping of RNA-Seq data [0.03%]
基于RNA-Seq数据的SNP定位识别家蚕抗虫品种幼虫CpGV转录组及潜在污染因子感染状况分析
Shili Yang,Maximilian Amberger,Jörg T Wennmann et al.
Shili Yang et al.
Various isolates of the Cydia pomonella granulovirus (CpGV) are used as insect pest control agents against codling moth (CM, Cydia pomonella L.), a predominant pest in apple orchards. Three different types (I-III) of dominantly inherited fi...
The laminin receptor is a receptor for Micropterus salmoides rhabdovirus [0.03%]
微鱼病毒结合宿主细胞的受体为层粘连蛋白受体蛋白
Sheng Luo,Jiahui Liang,Guanjun Yang et al.
Sheng Luo et al.
Micropterus salmoides rhabdovirus (MSRV) is an important pathogen of largemouth bass. Despite extensive research, the functional receptors of MSRV remained unknown. This study identified the host protein, laminin receptor (LamR), as a cellu...
Mouse and human immune responses share neutralization epitopes of HAstV-VA1 [0.03%]
小鼠和人类的免疫反应共享HAstV-VA1的中和表位
Inci Ramírez-Bello,Tomás López,Rafaela Espinosa et al.
Inci Ramírez-Bello et al.
Astroviruses are highly divergent and infect a wide variety of animal hosts. In 2009, a genetically divergent human astrovirus (HAstV) strain VA1 was first identified in an outbreak of acute gastroenteritis. This strain has also been associ...
The differences in cytokine signatures between severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) [0.03%]
发热伴血小板减少综合征（SFTS）和出血热（HFRS）细胞因子谱特征的区别分析
Zishuai Liu,Xiaoyu Xue,Shuying Geng et al.
Zishuai Liu et al.
Severe fever with thrombocytopenia syndrome (SFTS) virus and hantavirus are categorized under the Bunyavirales order. The severe disease progression in both SFTS and hemorrhagic fever with renal syndrome (HFRS) is associated with cytokine s...
Stacey Schultz-Cherry,Felicia Goodrum
Stacey Schultz-Cherry
All the single cells: if you like it then you should put some virus on it [0.03%]
孤“细胞”难求？喜欢它就给它来点病毒吧
Sophia K Adams,Grace E Ducharme,Emma K Loveday
Sophia K Adams
Across a rich 70-year history, single-cell virology has revealed the impact of host and pathogen heterogeneity during virus infections. Recent technological innovations have enabled higher-resolution analyses of cellular and viral heterogen...
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1 [0.03%]
肠道病毒3A蛋白通过与GBF1互作破坏内质网稳态
Junki Hirano,Tsuyoshi Hayashi,Kouichi Kitamura et al.
Junki Hirano et al.
Enteroviruses are single-stranded, positive-sense RNA viruses causing endoplasmic reticulum (ER) stress to induce or modulate downstream signaling pathways known as the unfolded protein responses (UPR). However, viral and host factors invol...
A BSL-2 compliant mouse model of SARS-CoV-2 infection for efficient and convenient antiviral evaluation [0.03%]
一种高效便捷的抗病毒评估的SARS-CoV-2感染小鼠BSL-2合规模型
Zinuo Chen,Qinghua Cui,Yan Ran et al.
Zinuo Chen et al.
Animal models of authentic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection require operation in biosafety level 3 (BSL-3) containment. In the present study, we established a mouse model employing a single-cycle infect...