Leny Jose,Keely Smith,Anaiya Crowner et al.
Leny Jose et al.
Three-stranded DNA-RNA structures known as R-loops that form during papillomavirus transcription can cause transcription-replication conflicts and lead to DNA damage. We found that R-loops accumulated at the viral early promoter in human pa...
What's going on with measles? [0.03%]
麻疹怎么了？
William J Moss,Diane E Griffin
William J Moss
Measles is a highly transmissible systemic viral infection associated with substantial mortality primarily due to secondary infections. Measles induces lifelong immunity to reinfection but loss of immunity to other pathogens. An attenuated ...
Structural determinants of spike infectivity in bat SARS-like coronaviruses RsSHC014 and WIV1 [0.03%]
决定蝙蝠SARS相关冠状病毒RsSHC014和WIV1刺突蛋白感染性的结构因素
Shuyuan Qiao,Xinquan Wang
Shuyuan Qiao
The recurrent spillovers of coronaviruses (CoVs) have posed severe threats to public health and the global economy. Bat severe acute respiratory syndrome (SARS)-like CoVs RsSHC014 and WIV1, currently circulating in bat populations, are pois...
The Raf kinase inhibitors Dabrafenib and Regorafenib impair Zika virus replication via distinct mechanisms [0.03%]
Dabrafenib和Regorafenib通过不同的机制抑制寨卡病毒的复制
Lucas Wilken,Guus F Rimmelzwaan,Husni Elbahesh
Lucas Wilken
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has been associated with congenital neurological defects in fetuses born to infected mothers. At present, no vaccine or antiviral therapy is available to combat this devastat...
AcMNPV-miR-2 affects Autographa californica nucleopolyhedrovirus infection by regulating the expression of ac28 and several other viral early genes [0.03%]
AcMNPV-miR-2通过调节ac28和其他几种病毒早期基因的表达影响家白点突角蚜病杆核病毒感染
Xinghua Yu,Tingkai Teng,Zhuowen Duan et al.
Xinghua Yu et al.
Virus-encoded microRNAs (miRNAs) exert diverse regulatory roles in the biological processes of both viruses and hosts. This study delves into the functions of AcMNPV-miR-2, an early miRNA encoded by Autographa californica multiple nucleopol...
Vaccine strains of Rift Valley fever virus exhibit attenuation at the maternal-fetal placental interface [0.03%]
裂谷热病毒疫苗株在母体-胎儿胎盘界面表现出减弱现象
Cynthia M McMillen,Christina Megli,Rebecca Radisic et al.
Cynthia M McMillen et al.
Rift Valley fever virus (RVFV) infection causes abortions in ruminant livestock and is associated with an increased likelihood of miscarriages in women. Using sheep and human placenta explant cultures, we sought to identify tissues at the m...
In vitro higher-order oligomeric assembly of the respiratory syncytial virus M2-1 protein with longer RNAs [0.03%]
含有较长RNA的呼吸道合胞病毒M2-1蛋白体外高阶寡聚化组装
Yunrong Gao,Anirudh Raghavan,Sara Andrea Espinosa Garcia et al.
Yunrong Gao et al.
The respiratory syncytial virus (RSV) M2-1 protein is a transcriptional antitermination factor crucial for efficiently synthesizing multiple full-length viral mRNAs. During RSV infection, M2-1 exists in a complex with mRNA within cytoplasmi...
Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis [0.03%]
单纯疱疹病毒ICP22与FACT相互作用对病毒基因表达和致病性的影响
Shaocong Liu,Yuhei Maruzuru,Kosuke Takeshima et al.
Shaocong Liu et al.
Facilitates chromatin transcription (FACT) interacts with nucleosomes to promote gene transcription by regulating the dissociation and reassembly of nucleosomes downstream and upstream of RNA polymerase II (Pol II). A previous study reporte...
AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection [0.03%]
LGG代谢产物的AhR配体通过活化猪肠驻留ILC3s分泌IL-22从而抑制PEDV感染
Junhong Wang,Yibo Zhao,Tong Cui et al.
Junhong Wang et al.
In maintaining organismal homeostasis, gut immunity plays a crucial role. The coordination between the microbiota and the immune system through bidirectional interactions regulates the impact of microorganisms on the host. Our research focu...
Serial cell culture passaging in vitro led to complete attenuation and changes in the characteristic features of a virulent porcine deltacoronavirus strain [0.03%]
体外连续传代可使高致病性猪δ冠状病毒毒力完全退化并改变其生物学特性
Liping Zhang,Ruiming Yu,Lianshun Wang et al.
Liping Zhang et al.
Porcine deltacoronavirus (PDCoV) is an important enteric coronavirus that has caused enormous economic losses in the pig industry worldwide. However, no commercial vaccine is currently available. Therefore, developing a safe and efficacious...