How does the polymerase of non-segmented negative strand RNA viruses commit to transcription or genome replication? [0.03%]
非段负链RNA病毒聚合酶如何决定转录或基因组复制？
Victoria A Kleiner,Rachel Fearns
Victoria A Kleiner
The Mononegavirales, or non-segmented negative-sense RNA viruses (nsNSVs), includes significant human pathogens, such as respiratory syncytial virus, parainfluenza virus, measles virus, Ebola virus, and rabies virus. Although these viruses ...
rAAV expressing a COBRA-designed influenza hemagglutinin generates a protective and durable adaptive immune response with a single dose [0.03%]
单剂表达COBRA设计的流感血凝素的rAAV可诱发保护和长效的适应性免疫反应
Kristin B Wiggins,Stephen M Winston,Isaiah L Reeves et al.
Kristin B Wiggins et al.
Influenza remains a worldwide public health threat. Although seasonal influenza vaccines are currently the best means of preventing severe disease, the standard-of-care vaccines require frequent updating due to antigenic drift and can have ...
Cell-surface d-glucuronyl C5-epimerase binds to porcine deltacoronavirus spike protein facilitating viral entry [0.03%]
细胞表面D-葡萄糖醛酸C5差向异构酶与猪 deltacoronavirus S 蛋白结合促进病毒感染入侵宿主细胞
Wenwen Xiao,Chaoqun Chen,Sijin Xia et al.
Wenwen Xiao et al.
Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus with zoonotic potential. The coronavirus spike (S) glycoprotein, especially the S1 subunit, mediates viral entry by binding to cellular receptors. However, the functi...
Molecular insight into the neutralization mechanism of human-origin monoclonal antibody AH100 against Hantaan virus [0.03%]
人源单克隆抗体AH100中和汉坦病毒的机制研究
Feiran Wang,Tiezhu Liu,Liying Liao et al.
Feiran Wang et al.
Both Old World and New World hantaviruses are transmitted through rodents and can lead to hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome in humans without the availability of specific therapeutics. The square-s...
Both middle and large envelope proteins can mediate neutralization of hepatitis B virus infectivity by anti-preS2 antibodies: escape by naturally occurring preS2 deletions [0.03%]
中间和大的包膜蛋白均可介导抗-preS2抗体对乙肝病毒感染活性的中和作用：由天然存在的preS2缺失所逃逸
Jing Zhang,Qianru Wang,Wenqing Yuan et al.
Jing Zhang et al.
Hepatitis B virus (HBV) expresses co-terminal large (L), middle (M), and small (S) envelope proteins containing preS1/preS2/S, preS2/S, and S domain alone, respectively. S and preS1 domains mediate sequential virion attachment to heparan su...
Effective inhibition of PDCoV infection in chimeric APN gene-edited neonatal pigs [0.03%]
利用嵌合型APN基因编辑仔猪有效抑制PDCoV感染
Jizong Li,Jian Zhou,Tianyi Zhang et al.
Jizong Li et al.
Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus, is a serious threat to piglets and has zoonotic potential. Here, we aimed to further explore the role of aminopeptidase N (APN) as a receptor for PDCoV and test the...
Participation of shrimp pva-miR-166 in hemocyte homeostasis by modulating apoptosis-related gene PvProsaposin during white spot syndrome virus infection [0.03%]
虾pva-miR-166通过调节白斑综合症病毒作用下与凋亡相关的基因PvProsapognin来参与血细胞稳态调控
Chantaka Wongdontri,Waruntorn Luangtrakul,Pakpoom Boonchuen et al.
Chantaka Wongdontri et al.
Tiny controllers referred to as microRNAs (miRNAs) impede the expression of genes to modulate biological processes. In invertebrates, particularly in shrimp as a model organism, it has been demonstrated that miRNAs play a crucial role in mo...
Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles [0.03%]
非感染性水痘带状疱疹病毒胞外囊泡通过抑制宿主抗病毒反应来促进病毒传播
Christy S Niemeyer,Seth Frietze,Christina Coughlan et al.
Christy S Niemeyer et al.
Varicella zoster virus (VZV) reactivates from ganglionic sensory neurons to produce herpes zoster (shingles) in a unilateral dermatomal distribution, typically in the thoracic region. Reactivation not only heightens the risk of stroke and o...
Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles [0.03%]
基于I类HLA等位基因的马赛克HIV-1疫苗方案产生差异型Gag和Env免疫反应的预测模型
George W Nelson,Janine van Duijn,Yuko Yuki et al.
George W Nelson et al.
HLA class I variation has the strongest effect genome-wide on outcome after HIV infection, and as such, an understanding of the impact of HLA polymorphism on response to HIV vaccination may inform vaccine design. We sought HLA associations ...
Clinical Trial
Journal of virology. 2024 Aug 20;98(8):e0028124. DOI:10.1128/jvi.00281-24 2024
E3 ligase RNF2 inhibits porcine circovirus type 3 replication by targeting its capsid protein for ubiquitination-dependent degradation [0.03%]
E3连接酶RNF2通过泛素依赖性降解衣壳蛋白抑制猪圆环病毒3型复制
Dedong Wang,Jie Zhao,Xiaoyu Yang et al.
Dedong Wang et al.
Porcine circovirus type 3 (PCV3) is closely associated with various diseases, such as the porcine dermatitis, nephropathy syndrome, and multisystemic clinicopathological diseases. PCV3-associated diseases are increasingly recognized as seve...