Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses [0.03%]
含锌指CCHC结构域的蛋白8通过抑制I型干扰素应答促进RNA病毒复制
Shaoyu Tu,Jiahui Zou,Chuhan Xiong et al.
Shaoyu Tu et al.
Host cells have evolved an intricate regulatory network to fine tune the type-I interferon responses. However, the full picture of this regulatory network remains to be depicted. In this study, we found that knock out of zinc-finger CCHC-ty...
The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence [0.03%]
缺乏证据即推广新冠病毒“实验室泄漏论”有害
James Alwine,Felicia Goodrum,Bruce Banfield et al.
James Alwine et al.
Science is humanity's best insurance against threats from nature, but it is a fragile enterprise that must be nourished and protected. The preponderance of scientific evidence indicates a natural origin for SARS-CoV-2. Yet, the theory that ...
Age-dependent Powassan virus lethality is linked to glial cell activation and divergent neuroinflammatory cytokine responses in a murine model [0.03%]
年龄依赖性Powassan病毒致命性与小胶质细胞活化及神经炎症细胞因子反应的差异有关：小鼠模型研究
Megan C Mladinich,Grace E Himmler,Jonas N Conde et al.
Megan C Mladinich et al.
Powassan virus (POWV) is an emergent tick-borne flavivirus that causes fatal encephalitis in the elderly and long-term neurologic sequelae in survivors. How age contributes to severe POWV encephalitis remains an enigma, and no animal models...
ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency [0.03%]
ORC1通过促进HIV-1潜伏增强HIV-1 LTR上的抑制性表观遗传修饰
Mo Zhou,Tao Yang,Ming Yuan et al.
Mo Zhou et al.
The human immunodeficiency virus type 1 (HIV-1) reservoir consists of latently infected cells which present a major obstacle to achieving a functional cure for HIV-1. The formation and maintenance of HIV-1 latency have been extensively stud...
The frequency and function of nucleoprotein-specific CD8+ T cells are critical for heterosubtypic immunity against influenza virus infection [0.03%]
核蛋白特异性CD8+t细胞的频率和功能对于异亚型流感病毒感染的异亚型免疫至关重要
Samuel Amoah,Weiping Cao,Ekramy E Sayedahmed et al.
Samuel Amoah et al.
Cytotoxic T lymphocytes (CTLs) mediate host defense against viral and intracellular bacterial infections and tumors. However, the magnitude of CTL response and their function needed to confer heterosubtypic immunity against influenza virus ...
Unraveling the assembly mechanism of SADS-CoV virus nucleocapsid protein: insights from RNA binding, dimerization, and epitope diversity profiling [0.03%]
SADS冠状病毒核衣壳蛋白组装机制的解析：来自RNA结合、二聚化及表位多样性分析的启示
Ying Zhang,Fang Wu,Yongyue Han et al.
Ying Zhang et al.
The swine acute diarrhea syndrome coronavirus (SADS-CoV) has caused significant disruptions in porcine breeding and raised concerns about potential human infection. The nucleocapsid (N) protein of SADS-CoV plays a vital role in viral assemb...
Sub-genomic flaviviral RNA elements increase the stability and abundance of recombinant AAV vector transcripts [0.03%]
副黄病毒亚基因组RNA元件可增加重组腺相关病毒载体转录本的稳定性和丰度
Rita M Meganck,Roza Ogurlu,Jiacheng Liu et al.
Rita M Meganck et al.
Many viruses have evolved structured RNA elements that can influence transcript abundance and translational efficiency, and help evade host immune factors by hijacking cellular machinery during replication. Here, we evaluated the functional...
Bis-benzylisoquinoline alkaloids inhibit African swine fever virus internalization and replication by impairing late endosomal/lysosomal function [0.03%]
双苯基异喹啉生物碱通过损害晚期内体/溶酶体功能来抑制非洲猪瘟病毒的内吞作用和复制
Junhai Zhu,Huahan Chen,Fei Gao et al.
Junhai Zhu et al.
African swine fever (ASF), caused by the African swine fever virus (ASFV), is a highly infectious disease afflicting domestic pigs and wild boars. It exhibits an alarming acute infection fatality rate of up to 100%. Regrettably, no commerci...
Conserved cysteine residues in Kaposi's sarcoma herpesvirus ORF34 are necessary for viral production and viral pre-initiation complex formation [0.03%]
保守的半胱氨酸残基对于卡波西肉瘤疱疹病毒ORF34的病毒产生和病毒转录起始复合物形成是必需的
Tadashi Watanabe,Aidan McGraw,Kedhar Narayan et al.
Tadashi Watanabe et al.
Kaposi's sarcoma herpesvirus (KSHV) ORF34 plays a significant role as a component of the viral pre-initiation complex (vPIC), which is indispensable for late gene expression across beta- and gammaherpesviruses. Although the key role of ORF3...
Japanese encephalitis virus NS5 protein interacts with nucleolin to enhance the virus replication [0.03%]
日本脑炎病毒NS5蛋白通过与核仁素结合来增强病毒复制
Arundhati Deb,Shilpi Nagpal,Rajnesh Kumari Yadav et al.
Arundhati Deb et al.
Japanese encephalitis virus (JEV) is an arthropod-borne, plus-strand flavivirus causing viral encephalitis in humans with a high case fatality rate. The JEV non-structural protein 5 (NS5) with the RNA-dependent RNA polymerase activity inter...