Strain-specific differences in the interactions of the cucumber mosaic virus 2b protein with the viral 1a and host Argonaute 1 proteins [0.03%]
黄瓜花叶病毒2b蛋白与该病毒1a蛋白和宿主AGO1互作的株系特异性差异分析
Sam Crawshaw,Lewis G Watt,Alex M Murphy et al.
Sam Crawshaw et al.
The cucumber mosaic virus (CMV) 2b protein is a potent counter-defense factor and symptom determinant that inhibits antiviral silencing by titrating short double-stranded RNAs. Expression of the CMV subgroup IA strain Fny-CMV 2b protein in ...
Mouse hepatitis virus JHMV I protein is required for maximal virulence [0.03%]
MHV-JHMV I蛋白对病毒毒力是必需的
Shea A Lowery,Noah Schuster,Lok-Yin Roy Wong et al.
Shea A Lowery et al.
Betacoronaviruses encode a conserved accessory gene within the +1 open reading frame (ORF) of nucleocapsid called the internal N gene. This gene is referred to as "I" for mouse hepatitis virus (MHV), ORF9b for severe acute respiratory CoV (...
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism [0.03%]
两种新型化合物通过靶向脂质代谢抑制 flaviviruses 病毒的体内和体外感染
Jiang-Fei Zhou,Meng-Ran Zhang,Qi Wang et al.
Jiang-Fei Zhou et al.
Flavivirus infection capitalizes on cellular lipid metabolism to remodel the cellular intima, creating a specialized lipid environment conducive to viral replication, assembly, and release. The Japanese encephalitis virus (JEV), a member of...
A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets [0.03%]
一种针对猪德尔塔冠状病毒的刺突基元mrna疫苗可诱导仔猪产生长效和广谱保护力
Jizong Li,Li Xiao,Zhuoqi Chen et al.
Jizong Li et al.
Coronaviruses (CoVs) are important pathogens for humans and other vertebrates, causing severe respiratory and intestinal infections that have become a threat to public health because of the potential for interspecies transmission between an...
Probing Gag-Env dynamics at HIV-1 assembly sites using live-cell microscopy [0.03%]
应用活细胞显微镜技术探究HIV-1组装部位的Gag-Env动态变化
Frauke Muecksch,Severina Klaus,Vibor Laketa et al.
Frauke Muecksch et al.
Human immunodeficiency virus (HIV)-1 assembly is initiated by Gag binding to the inner leaflet of the plasma membrane (PM). Gag targeting is mediated by its N-terminally myristoylated matrix (MA) domain and PM phosphatidylinositol 4,5-bisph...
Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs [0.03%]
基于mRNA编码和蛋白质的HIV-1 Env-铁蛋白纳米颗粒设计的免疫原性比较
Zekun Mu,Jill Whitley,Diana Martik et al.
Zekun Mu et al.
Nucleoside-modified mRNA technology has revolutionized vaccine development with the success of mRNA COVID-19 vaccines. We used modified mRNA technology for the design of envelopes (Env) to induce HIV-1 broadly neutralizing antibodies (bnAbs...
Comparative Study
Journal of virology. 2024 Sep 17;98(9):e0013724. DOI:10.1128/jvi.00137-24 2024
Disruption of herpes simplex virus type 2 pUL21 phosphorylation impairs secondary envelopment of cytoplasmic nucleocapsids [0.03%]
HSV-2糖蛋白pUL21磷酸化缺陷损害细胞质核衣壳的二次包被
Renée L Finnen,Jamil H Muradov,Valerie Le Sage et al.
Renée L Finnen et al.
The multifunctional tegument protein pUL21 of HSV-2 is phosphorylated in infected cells. We have identified two residues in the unstructured linker region of pUL21, serine 251 and serine 253, as phosphorylation sites. Both phosphorylation s...
The Rab6 post-Golgi secretory pathway contributes to herpes simplex virus 1 (HSV-1) egress [0.03%]
Rab6后高尔基体分泌途径参与单纯疱疹病毒1型(HSV-1)的出芽释放过程
Melissa H Bergeman,Kimberly Velarde,Hailee L Hargis et al.
Melissa H Bergeman et al.
Herpes simplex virus 1 (HSV-1) is an alpha herpesvirus that infects a majority of the world population. The mechanisms and cellular host factors involved in the intracellular transport and exocytosis of HSV-1 particles are not fully underst...
Propagating and banking genetically diverse human sapovirus strains using a human duodenal cell line: investigating antigenic differences between strains [0.03%]
利用人类十二指肠细胞系增殖和保存基因型多样的人雪投病毒菌株并研究各菌株之间的抗原差异
Tomoichiro Oka,Tian-Cheng Li,Kenzo Yonemitsu et al.
Tomoichiro Oka et al.
There are four genogroups and 18 genotypes of human sapoviruses (HuSaVs) responsible for acute gastroenteritis. To comprehend their antigenic and virological differences, it is crucial to obtain viral stocks of the different strains. Previo...
SARS-CoV-2 papain-like protease inhibits ISGylation of the viral nucleocapsid protein to evade host anti-viral immunity [0.03%]
新型冠状病毒的半胱氨酸蛋白酶抑制核衣壳蛋白ISG化以对抗宿主抗病毒免疫反应
Aulia Fitri Rhamadianti,Takayuki Abe,Tomohisa Tanaka et al.
Aulia Fitri Rhamadianti et al.
A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes mild-to-severe respiratory symptoms, including acute respiratory distress. Despite remarkable efforts to investigate the virological and pathological impacts of...