Foot-and-mouth disease virus (FMDV) negatively regulates ZFP36 protein expression to alleviate its antiviral activity [0.03%]
口足病病毒通过抑制ZFP36蛋白表达来缓解其抗病毒活性
Mengge Yin,Ping Qian,Haoyuan Wang et al.
Mengge Yin et al.
Zinc finger protein 36 (ZFP36) is a key regulator of inflammatory and cytokine production. However, the interplay between swine zinc-finger protein 36 (sZFP36) and foot-and-mouth disease virus (FMDV) has not yet been reported. Here, we demo...
Pan-beta-coronavirus subunit vaccine prevents SARS-CoV-2 Omicron, SARS-CoV, and MERS-CoV challenge [0.03%]
泛β冠状病毒亚单位疫苗可预防SARS-CoV-2奥密克戎毒株、SARS-CoV和MERS-CoV的感染
Gang Wang,Abhishek K Verma,Xiaoqing Guan et al.
Gang Wang et al.
Three highly pathogenic coronaviruses (CoVs), SARS-CoV-2, SARS-CoV, and MERS-CoV, belonging to the genus beta-CoV, have caused outbreaks or pandemics. SARS-CoV-2 has evolved into many variants with increased resistance to the current vaccin...
Small hydrophobic (SH) proteins of Pneumoviridae and Paramyxoviridae: small but mighty [0.03%]
副粘病毒科和 pneumoviridae 的小疏水性 (SH) 蛋白：小巧但威力强大
Adam Brynes,John V Williams
Adam Brynes
Small hydrophobic (SH) proteins are a class of viral accessory proteins expressed by many members of the negative-stranded RNA viral families Paramyxoviridae and Pneumoviridae. Identified SH proteins are type I or II transmembrane (TM) prot...
Deciphering the adsorption machinery of Deep-Blue and Vp4, two myophages targeting members of the Bacillus cereus group [0.03%]
揭开针对芽孢杆菌属两大肌病毒深蓝和Vp4的吸附机制
Manon Nuytten,Audrey Leprince,Adeline Goulet et al.
Manon Nuytten et al.
In tailed phages, the baseplate is the macromolecular structure located at the tail distal part, which is directly implicated in host recognition and cell wall penetration. In myophages (i.e., with contractile tails), the baseplate is compl...
Intranasal administration of octavalent next-generation influenza vaccine elicits protective immune responses against seasonal and pre-pandemic viruses [0.03%]
八价新一代流感疫苗鼻内给药对季节性和大流行流感病毒株产生保护性免疫反应
Naoko Uno,Thomas Ebensen,Carlos A Guzman et al.
Naoko Uno et al.
Development of next-generation influenza virus vaccines is crucial to improve protection against circulating and emerging viruses. Current vaccine formulations have to be updated annually due to mutations in seasonal strains and do not offe...
Incompatible packaging signals and impaired protein functions hinder reassortment of bat H17N10 or H18N11 segment 7 with human H1N1 influenza A viruses [0.03%]
蝙蝠H17N10或H18N11的段7与人类H1N1流感A病毒重组受阻
Liping Wang,Lei Shi,Heidi Liu et al.
Liping Wang et al.
Novel bat H17N10 and H18N11 influenza A viruses (IAVs) are incapable of reassortment with conventional IAVs during co-infection. To date, the underlying mechanisms that inhibit bat and conventional IAV reassortment remain poorly understood....
Zebrafish phd1 enhances mavs-mediated antiviral responses in a hydroxylation-independent manner [0.03%]
斑马鱼phd1以羟基化非依赖性的方式增强mavs介导的抗病毒反应
Guangqing Yu,Le Yuan,Xiong Li et al.
Guangqing Yu et al.
PHD1 is a member of the prolyl hydroxylase domain protein (PHD1-4) family, which plays a prominent role in the post-translational modification of its target proteins by hydroxylating proline residues. The best-characterized targets of PHD1 ...
Afucosylated anti-EBOV antibody MIL77-3 engages sGP to elicit NK cytotoxicity [0.03%]
岩藻糖基化抗埃博拉病毒抗体MIL77-3通过与sGP结合激发自然杀伤细胞毒性作用
Yuting Zhang,Min Zhang,Haiyan Wu et al.
Yuting Zhang et al.
MIL77-3 is one component of antibody cocktail that is produced in our lab and represents an effective regimen for animals suffering from Zaire Ebolavirus (EBOV) infection. MIL77-3 is engineered to increase its affinity for the FcγRIIIa (CD...
CGRP inhibits SARS-CoV-2 infection of bronchial epithelial cells, and its pulmonary levels correlate with viral clearance in critical COVID-19 patients [0.03%]
CGRP抑制SARS-CoV-2对支气管上皮细胞的感染，且其肺部水平与危重COVID-19患者的病毒清除相关性良好
Caio César Barbosa Bomfim,Hugo Génin,Andréa Cottoignies-Callamarte et al.
Caio César Barbosa Bomfim et al.
Upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), patients with critical coronavirus disease 2019 (COVID-19) present with life-threatening respiratory distress, pulmonary damage, and cytokine storm. One unexp...
Viral and cellular determinants of polarized trafficking of viral envelope proteins from insect-specific and insect-vectored viruses in insect midgut and salivary gland cells [0.03%]
昆虫肠道和唾液腺细胞中特异性昆虫病毒和介体传播病毒的包膜蛋白极性转运的病毒和宿主细胞决定因素
Jeffrey J Hodgson,Robin Y Chen,Gary W Blissard et al.
Jeffrey J Hodgson et al.
Systemic viral infection of insects typically begins with the primary infection of midgut epithelial cells (enterocytes) and subsequent transit of the progeny virus in an apical-to-basal orientation into the hemocoel. For insect-vectored vi...