Efficacy of late-onset antiviral treatment in immunocompromised hosts with persistent SARS-CoV-2 infection [0.03%]
免疫功能低下者持续性新型冠状病毒感染的晚期抗病毒治疗效果
Carolin M Lieber,Hae-Ji Kang,Elizabeth B Sobolik et al.
Carolin M Lieber et al.
Immunocompromised people are at high risk of prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and progression to severe coronavirus disease 2019 (COVID-19). However, the efficacy of late-onset direct-acting a...
The 5'UTR of porcine reproductive and respiratory syndrome virus strain JXwn06 harbors a uORF that regulates cellular inflammation [0.03%]
猪繁殖与呼吸综合征病毒JXwn06株的5'UTR含有一个调控细胞炎性反应的uORF
Teng Liu,Qi Shao,Zhiying Cui et al.
Teng Liu et al.
The 5' untranslated region (5'UTR) of many positive-stranded RNA viruses contain functional regulatory sequences. Here, we show that the porcine reproductive and respiratory syndrome virus (PRRSV), a member of arteriviruses, harbors small u...
Respiratory syncytial virus infection provides protection against severe acute respiratory syndrome coronavirus challenge [0.03%]
呼吸道合胞病毒感染对严重急性呼吸综合征冠状病毒攻击具有保护作用
Stacey M Hartwig,Abby Odle,Lok-Yin Roy Wong et al.
Stacey M Hartwig et al.
Respiratory infections are a major health burden worldwide. Respiratory syncytial virus (RSV) is among the leading causes of hospitalization in both young children and older adults. The onset of the severe acute respiratory syndrome coronav...
Ipsilateral or contralateral boosting of mice with mRNA vaccines confers equivalent immunity and protection against a SARS-CoV-2 Omicron strain [0.03%]
同侧或对侧注射mRNA疫苗的小鼠可获得针对奥密克戎毒株的相当的免疫力和保护力
Baoling Ying,Chieh-Yu Liang,Pritesh Desai et al.
Baoling Ying et al.
Boosting with mRNA vaccines encoding variant-matched spike proteins has been implemented to mitigate their reduced efficacy against emerging SARS-CoV-2 variants. Nonetheless, in humans, it remains unclear whether boosting in the ipsilateral...
A reporter Oropouche virus expressing ZsGreen from the M segment enables pathogenesis studies in mice [0.03%]
Oropouche病毒M段ZsGreen表达基因工程重组毒用于小鼠内感染发病机制研究
Krista Gunter,Dorcus Omoga,James M Bowen et al.
Krista Gunter et al.
Oropouche fever caused by Oropouche virus (OROV) is a significant zoonosis in Central and South America. Despite its public health significance, we lack high-throughput diagnostics, therapeutics, and a comprehensive knowledge of OROV biolog...
ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis [0.03%]
HERC5对SARS-CoV-2 N蛋白的ISG化作用可阻碍N聚合并抑制病毒RNA合成
Junji Zhu,GuanQun Liu,Zuberwasim Sayyad et al.
Junji Zhu et al.
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like protein, is covalently conjugated to host immune proteins such as MDA5 and IRF3 in a process called ISGylation, thereby promoting type I IFN induction to limit the replication of...
Liquid-liquid phase separation is essential for reovirus viroplasm formation and immune evasion [0.03%]
液-液相分离对重病毒增殖和免疫逃逸至关重要
Libo He,Qian Wang,Xuyang Wang et al.
Libo He et al.
Grass carp reovirus (GCRV) is the most virulent pathogen in the genus Aquareovirus, belonging to the family Spinareoviridae. Members of the Spinareoviridae family are known to replicate and assemble in cytoplasmic inclusion bodies termed vi...
Human papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA [0.03%]
人乳头瘤病毒16型复制将SAMHD1蛋白转化为同源重组因子并促进其募集到复制中的病毒DNA上
Claire D James,Aya Youssef,Apurva T Prabhakar et al.
Claire D James et al.
We have demonstrated that SAMHD1 (sterile alpha motif and histidine-aspartic domain HD-containing protein 1) is a restriction factor for the human papillomavirus 16 (HPV16) life cycle. Here, we demonstrate that in HPV-negative cervical canc...
Influenza virus antibodies inhibit antigen-specific de novo B cell responses in mice [0.03%]
流感病毒抗体可抑制小鼠抗原特异性初始B细胞反应
Eileen Goodwin,James S Gibbs,Jonathan W Yewdell et al.
Eileen Goodwin et al.
Antibody responses to influenza vaccines tend to be focused on epitopes encountered during prior influenza exposures, with little production of de novo responses to novel epitopes. To examine the contribution of circulating antibodies to th...
Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis [0.03%]
柯萨奇病毒B3型通过调节ASS1介导的代谢重编程促进心肌炎中巨噬细胞向促炎表型极化
Qiong Liu,Yinpan Shang,Ziwei Tao et al.
Qiong Liu et al.
Coxsackievirus group B3 (CVB3) belongs to the genus Enteroviruses of the family Picornaviridae and is the main pathogen underlying viral myocarditis (VMC). No specific therapeutic is available for this condition. Argininosuccinate synthase ...