Two amino acid residues in the N-terminal region of the polymerase acidic protein determine the virulence of Eurasian avian-like H1N1 swine influenza viruses in mice [0.03%]
猪繁殖与呼吸综合征病毒P蛋白C末端区域的两个氨基酸残基调控内源性siRNA生成及其毒力属性
Yuying Yang,Chengzhi Xu,Naixin Zhang et al.
Yuying Yang et al.
Reassortant Eurasian avian-like H1N1 (rEA H1N1) viruses carrying the internal genes of H1N1/2009 virus have been circulating in pigs for more than 10 years and have caused sporadic human infections. The enhanced virulence phenotype of the r...
UBE3C restricts EV-A71 replication by ubiquitination-dependent degradation of 2C [0.03%]
UBE3C通过泛素化降解EV-A71的2C蛋白限制EV-A71复制
Boming Cui,Ge Yang,Haiyan Yan et al.
Boming Cui et al.
Ubiquitin modification of viral proteins to degrade or regulate their function is one of the strategies of the host to resist viral infection. Here, we report that ubiquitin protein ligase E3C (UBE3C), an E3 ubiquitin ligase, displayed inhi...
Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication [0.03%]
伪狂犬病毒通过诱导线粒体自噬抑制I型干扰素产生以促进病毒复制
Yuan Zhao,Chan Ding,Zhenbang Zhu et al.
Yuan Zhao et al.
Pseudorabies virus (PRV) utilizes multiple strategies to inhibit type I interferon (IFN-I) production and signaling to achieve innate immune evasion. Among several other functions, mitochondria serve as a crucial immune hub in the initiatio...
Loopy virus or controlled contortionist? 3D regulation of HCMV gene expression by CTCF-driven chromatin interactions [0.03%]
环形病毒还是受控变形者？CTCF驱动的染色质相互作用对HCMV基因表达的三维调控
Ian J Groves,Christine M O&#x;Connor
Ian J Groves
Three-dimensional chromatin control of eukaryotic transcription is pivotal for regulating gene expression. This additional layer of epigenetic regulation is also utilized by DNA viruses, including herpesviruses. Dynamic, spatial genomic org...
Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus [0.03%]
激活ATF3的综合应力反应通路调节先天性免疫应答以限制寨卡病毒感染
Pheonah Badu,Gabriele Baniulyte,Morgan A Sammons et al.
Pheonah Badu et al.
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that can have devastating health consequences. The developmental and neurological effects of a ZIKV infection arise in part from the virus triggering cellular stress pathways and ...
Correction for Hu et al., "Mast Cell-Induced Lung Injury in Mice Infected with H5N1 Influenza Virus" [0.03%]
对胡等人的论文“H5N1流感病毒感染小鼠诱导的肥大细胞介导的肺损伤”的更正
Yanxin Hu,Yi Jin,Deping Han et al.
Yanxin Hu et al.
Published Erratum
Journal of virology. 2024 Sep 17;98(9):e0110624. DOI:10.1128/jvi.01106-24 2024
Regulation of the cell surface expression of classical and non-classical MHC proteins by the human cytomegalovirus UL40 and rhesus cytomegalovirus Rh67 proteins [0.03%]
人巨细胞病毒UL40和恒河猴巨细胞病毒Rh67蛋白对经典MHCI类分子与非经典MHCI类分子细胞表面表达的调控作用研究
Simon Brackenridge,Nessy John,Wanlin He et al.
Simon Brackenridge et al.
The signal sequences of the human cytomegalovirus (CMV) UL40 protein and its rhesus CMV (RhCMV) counterpart, Rh67, contain a peptide (VMAPRT[L/V][F/I/L/V]L, VL9) that is presented by major histocompatibility complex (MHC) antigen E (MHC-E)....
VP3 protein of Senecavirus A promotes viral IRES-driven translation and attenuates innate immunity by specifically relocalizing hnRNPA2B1 [0.03%]
Senecavirus A VP3蛋白通过特异性重新定位hnRNPA2B1来促进病毒IRES介导的翻译并抑制先天免疫应答
Lu Li,Xinwei Li,Han Zhong et al.
Lu Li et al.
Viruses deploy sophisticated strategies to hijack the host's translation machinery to favor viral protein synthesis and counteract innate cellular defenses. However, little is known about the mechanisms by which Senecavirus A (SVA) controls...
A nanobody interaction with SARS-COV-2 Spike allows the versatile targeting of lentivirus vectors [0.03%]
一种与SARS-CoV-2刺突蛋白相互作用的纳米抗体可实现 Lentiviral载体的多功能靶向
Ayna Alfadhli,Timothy A Bates,Robin Lid Barklis et al.
Ayna Alfadhli et al.
While investigating methods to target gene delivery vectors to specific cell types, we examined the potential of using a nanobody against the SARS-CoV-2 Spike protein receptor-binding domain to direct lentivirus infection of Spike-expressin...
Infiltrating monocytes drive cardiac dysfunction in a cardiomyocyte-restricted mouse model of SARS-CoV-2 infection [0.03%]
在SARS-CoV-2感染的心肌细胞限制性小鼠模型中，渗入的单核细胞驱动心脏功能障碍
Oleksandr Dmytrenko,Shibali Das,Attila Kovacs et al.
Oleksandr Dmytrenko et al.
Cardiovascular manifestations of coronavirus disease 2019 (COVID-19) include myocardial injury, heart failure, and myocarditis and are associated with long-term disability and mortality. Severe acute respiratory syndrome coronavirus 2 (SARS...