Identification of amino acid residue in the Cronobacter sakazakii LamB responsible for the receptor compatibility of polyvalent coliphage CSP1 [0.03%]
沙门氏菌LT7噬菌体的宿主范围及耐药性质研究
Moosung Kim,Minsik Kim,Sangryeol Ryu
Moosung Kim
Polyvalent bacteriophages show the feature of infecting bacteria across multiple species or even orders. Infectivity of a polyvalent phage is variable depending on the host bacteria, which can disclose differential inhibition of bacteria by...
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity [0.03%]
三种CD4诱导抗体与一种小分子CD4模拟化合物针对高度保守的Env区域结合，可实现强力ADCC活性
Lorie Marchitto,Jonathan Richard,Jérémie Prévost et al.
Lorie Marchitto et al.
The majority of naturally elicited antibodies against the HIV-1 envelope glycoproteins (Env) are non-neutralizing (nnAbs) because they are unable to recognize the Env trimer in its native "closed" conformation. Nevertheless, it has been sho...
Conformations of membrane human immunodeficiency virus (HIV-1) envelope glycoproteins solubilized in Amphipol A18 lipid-nanodiscs [0.03%]
溶解在两性离子脂质纳米盘Amphipol A18中的膜人免疫缺陷病毒(HIV-1)包膜糖蛋白构象
Shijian Zhang,Saumya Anang,Zhiqing Zhang et al.
Shijian Zhang et al.
Upon binding to the host cell receptor, CD4, the pretriggered (State-1) conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer undergoes transitions to downstream conformations important for virus entry....
A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease [0.03%]
一种针对 nipah 病毒融合糖蛋白顶点的单克隆抗体可预防疾病产生
Victoria A Avanzato,Trenton Bushmaker,Kasopefoluwa Y Oguntuyo et al.
Victoria A Avanzato et al.
Nipah virus (NiV) is a highly pathogenic paramyxovirus capable of causing severe respiratory and neurologic disease in humans. Currently, there are no licensed vaccines or therapeutics against NiV, underscoring the urgent need for the devel...
A cardioviral 2C-ATP complex structure reveals the essential role of a conserved arginine in regulation of cardioviral 2C activity [0.03%]
心血管病毒2C-ATP复合物结构揭示了保守精氨酸在调节心血管病毒2C活性中的重要作用
Qing-Yi He,Hai-Fan Zhao,Liang Meng et al.
Qing-Yi He et al.
2C is a highly conserved picornaviral non-structural protein with ATPase activity and plays a multifunctional role in the viral life cycle as a promising target for anti-picornavirus drug development. While the structure-function of enterov...
Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env [0.03%]
CDRL1缩短的中间VRC01样抗体无法克服HIV-1 Env上的关键糖基障碍物
Parul Agrawal,Maria L Knudsen,Anna MacCamy et al.
Parul Agrawal et al.
VRC01-class broadly neutralizing antibodies (bnAbs) have been isolated from people with HIV-1, but they have not yet been elicited by vaccination. They are extensively somatically mutated and sometimes accumulate CDRL1 deletions. Such indel...
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics [0.03%]
HIV感染者血浆中三类CD4诱导抗体介导的ADCC效应及其与CD4模拟肽的关系
Alexandra Tauzin,Lorie Marchitto,Étienne Bélanger et al.
Alexandra Tauzin et al.
CD4-mimetics (CD4mcs) are small molecule compounds that mimic the interaction of the CD4 receptor with HIV-1 envelope glycoproteins (Env). Env from primary viruses normally samples a "closed" conformation that occludes epitopes recognized b...
Immunogenicity and efficacy of XBB.1.5 rS vaccine against the EG.5.1 variant of SARS-CoV-2 in Syrian hamsters [0.03%]
针对叙利亚仓鼠中沙斯冠状病毒2型EG.5.1变异株的XBB.1.5 rS疫苗的免疫原性和效力研究
Nadia Soudani,Traci L Bricker,Tamarand Darling et al.
Nadia Soudani et al.
The continued emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates updating coronavirus disease 2019 (COVID-19) vaccines to match circulating strains. The immunogenicity and efficacy of these vacci...
A three-way interface of the Nipah virus phosphoprotein X-domain coordinates polymerase movement along the viral genome [0.03%]
nipah病毒磷蛋白X结构域三管齐下的界面可协调聚合酶沿病毒基因组的运动
Josef D Wolf,Richard K Plemper
Josef D Wolf
Nipah virus (NiV) is a highly pathogenic paramyxovirus causing frequently lethal encephalitis in humans. The NiV genome is encapsidated by the nucleocapsid (N) protein. RNA synthesis is mediated by the viral RNA-dependent RNA polymerase (Rd...
Envelope domain III E324, E351, and E380 mutations lever adaptive evolution of DENV-1 genotype I [0.03%]
Envelope第III包膜域E324、E351和E380的突变推动DENV-1Ⅰ型适应性演化
Tao Jiang,Chenxiao Huang,Qianqian Ruan et al.
Tao Jiang et al.
Dengue virus (DENV) gains genetic mutations during continuous transmission and evolution, making the virus more adaptive and virulent. The clade of DENV-1 genotype I has expanded and become the predominant genotype in Asia and the Pacific a...