PRRSV non-structural protein 5 inhibits antiviral innate immunity by degrading multiple proteins of RLR signaling pathway through FAM134B-mediated ER-phagy [0.03%]
非结构蛋白5通过FAM134B介导的内质网自噬降解RIG-I信号通路的多个组分来抑制抗病毒天然免疫
Jing Wang,Huiqin Sun,Rui Li et al.
Jing Wang et al.
Viruses employ various evasion strategies to establish prolonged infection, with evasion of innate immunity being particularly crucial. Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant pathogen in swine industry,...
Characterization of bi-segmented and tri-segmented recombinant Pichinde virus particles [0.03%]
双节段和三节段的嵌合型Pichinde病毒粒子的表征
Hannah Murphy,Qinfeng Huang,Jacob Jensen et al.
Hannah Murphy et al.
Mammarenaviruses include several highly virulent pathogens (e.g., Lassa virus) capable of causing severe hemorrhagic fever diseases for which there are no approved vaccines and limited treatment options. Mammarenaviruses are enveloped, bi-s...
How to introduce a new bacteriophage on the block: a short guide to phage classification [0.03%]
噬菌体分类简明指导
Guadalupe Valencia-Toxqui,Jolene Ramsey
Guadalupe Valencia-Toxqui
Bacteriophage (phage) studies established the field of molecular biology and continue to propel life science research forward due to their diversity, abundance, and potential applications. In this Gem article, we orient newcomers to four co...
Oral co-administration of Lactiplantibacillus plantarum 16 and Lacticaseibacillus rhamnosus P118 improves host defense against influenza A virus infection [0.03%]
枯草芽孢杆菌植物株16和鼠李糖乳杆菌P118联合口服给药可增强宿主对甲型流感病毒的防御作用
Meiqing Han,Qi Lu,Di Wang et al.
Meiqing Han et al.
Influenza is an important zoonotic disease that persistently threatens global public health. While it is widely acknowledged that probiotics can modulate the host response to protect the host against infectious disease, the prophylactic eff...
Characterization of HPV6/11-reactive T-cell subsets in papillomas of patients with juvenile-onset recurrent respiratory papillomatosis and identification of HPV11 E7-specific candidate TCR clonotypes [0.03%]
复发性呼吸道乳头状瘤病患者乳头状瘤中HPV6/11反应性T细胞亚群的特征鉴定及HPV11E7特异性TCR克隆型候选物识别
Yun Peng,Wei Wang,Xiangjun Liu et al.
Yun Peng et al.
Juvenile-onset recurrent respiratory papillomatosis (JORRP) is caused by persistent infection of epithelial cells by low-risk human papillomavirus (HPV) types 6 and 11. While multiple infiltrated immune cells have been reported to mediate d...
Genomic transfer via membrane vesicle: a strategy of giant phage phiKZ for early infection [0.03%]
通过膜囊泡的基因组转移：巨型噬菌体phiKZ早期感染的策略
Daria Antonova,Anna Nichiporenko,Mariia Sobinina et al.
Daria Antonova et al.
During infection, the giant phiKZ phage forms a specialized structure at the center of the host cell called the phage nucleus. This structure is crucial for safeguarding viral DNA against bacterial nucleases and for segregating the transcri...
HIV-induced RSAD2/Viperin supports sustained infection of monocyte-derived macrophages [0.03%]
HIV诱导的RSAD2/Viperin支持单核细胞衍生巨噬细胞的持续感染
Urvi Zankharia,Yanjie Yi,Fang Lu et al.
Urvi Zankharia et al.
HIV establishes long-term latent infection in memory CD4+ T cells and also establishes sustained long-term productive infection in macrophages, especially in the central nervous system (CNS). To better understand how HIV sustains infection ...
Efficacy evaluation of a bivalent subunit vaccine against epidemic PEDV heterologous strains with low cross-protection [0.03%]
一种低交叉保护率的流行PEDV异源毒株双价亚单位疫苗的效果评估
Xu Song,Yunchuan Li,Chuanhong Wang et al.
Xu Song et al.
Variant Porcine epidemic diarrhea virus (PEDV), which causes diarrhea and high mortality in piglets, has become a major pathogen, and co-epidemics of different subtypes of the virus have become a very thorny problem for the clinical prevent...
Newcastle disease virus induces clathrin-mediated endocytosis to establish infection through the activation of PI3K/AKT signaling pathway by VEGFR2 [0.03%]
新城疫病毒通过血管内皮生长因子受体2活化PI3K/AKT信号途径诱导依赖于网格蛋白的内吞作用来建立感染
Lei Fan,Hongtao Xiao,Jinlian Ren et al.
Lei Fan et al.
The phosphatidyl-inositol 3-kinase/serine-threonine kinase (PI3K/ AKT) signaling pathway constitutes a classical phosphorylation cascade that integrates tyrosine, lipid, and serine acid-threonine phosphorylation, affecting cell function. Th...
The class III phosphatidylinositol 3-kinase VPS34 supports EV71 replication by promoting viral replication organelle formation [0.03%]
III类磷脂酰肌醇3-激酶VPS34通过促进病毒复制小体的形成来促进EV71的复制
Bo Wu,Tingting Fan,Xinrui Chen et al.
Bo Wu et al.
Enterovirus 71 (EV71) belongs to the family of Picornaviridae; it could cause a variety of illnesses and pose a great threat to public health worldwide. Currently, there is no specific drug treatment for this virus, and a better understandi...