Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor for the endogenous retroviral envelope syncytin-B involved in mouse placenta formation [0.03%]
内源性逆转录病毒包膜蛋白.syncytin-B.的宿主受体是磷酸盐转运蛋白PiT1/SLC20A1：对小鼠胎盘形成的研究
Guillaume Mousseau,Noémie Préault,Sylvie Souquere et al.
Guillaume Mousseau et al.
Syncytins are envelope genes of retroviral origin that play a critical role in the formation of a syncytial structure at the fetomaternal interface via their fusogenic activity. The mouse placenta is unique among placental mammals since the...
hnRNP H controls alternative splicing of human papillomavirus type 16 E1, E6, E7, and E6^E7 mRNAs via GGG motifs [0.03%]
hnRNP H通过GGG基序控制人类乳头瘤病毒16型E1、E6、E7及E6^E7mRNA的可变剪接
Johanna Jönsson,Qiaoli Zhai,Stefan Schwartz et al.
Johanna Jönsson et al.
The mRNAs encoding the human papillomavirus type 16 (HPV16) E6 and E7 oncogene mRNAs are subjected to extensive alternative RNA splicing at multiple regulated splice sites. One of the most extensively used 5'-splice sites in the HPV16 genom...
Vascular endothelial growth factor receptor 2 as a potential host target for the inhibition of enterovirus replication [0.03%]
血管内皮生长因子受体2作为抑制肠道病毒复制的宿主靶点的潜力研究
Xiaoyu Zhao,Rui Qiao,Meng Hao et al.
Xiaoyu Zhao et al.
Because host kinases are key regulators of multiple signaling pathways in response to viral infections, we previously screened a kinase inhibitor library using rhabdomyosarcoma cells and human intestinal organoids in parallel to identify po...
Palmitoylation of SARS-CoV-2 Envelope protein is central to virus particle formation [0.03%]
SARS-CoV-2包膜蛋白棕榈酰化对病毒颗粒形成至关重要
Zhaohuan Wang,Manman Qiu,Yue Ji et al.
Zhaohuan Wang et al.
The Envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an integral structural protein in the virus particles. However, its role in the assembly of virions and the underlying molecular mechanisms are yet ...
Conserved linear motif within the immediate early protein ORF45 promotes its engagement with KSHV lytic cycle-promoting forkhead transcription factors, FOXK1 and FOXK2 [0.03%]
保守的线性基序通过与促进KSHV 激活周期的FOXK1和FOXK2转录因子结合来调节ORF45的功能
Marley Palmer,Alessandro Leo,Natalie Atyeo et al.
Marley Palmer et al.
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that can cause several cancers, such as Kaposi sarcoma and primary effusion lymphoma (PEL). We and others have recently demonstrated that Forkhead box (FOX) transcription ...
Distinct negative-sense RNA viruses induce a common set of transcripts encoding proteins forming an extensive network [0.03%]
不同意义的RNA病毒引发一组独特的转录本编码形成广泛网络的蛋白质
Nina Hofmann,Marek Bartkuhn,Stephan Becker et al.
Nina Hofmann et al.
The large group of negative-strand RNA viruses (NSVs) comprises many important pathogens. To identify conserved patterns in host responses, we systematically compared changes in the cellular RNA levels after infection of human hepatoma cell...
Conjugation of anti-HIV gp41 monoclonal antibody to a drug capable of targeting resting lymphocytes produces an effective cytotoxic anti-HIV immunoconjugate [0.03%]
一种药物能够针对休止的淋巴细胞产生有效的细胞毒性抗HIV免疫共轭体
Seth H Pincus,Frances M Cole,Kelli Ober et al.
Seth H Pincus et al.
HIV-infected cells persisting in the face of suppressive antiretroviral therapy are the barrier to curing infection. Cytotoxic immunoconjugates targeted to HIV antigens on the cell surface may clear these cells. We showed efficacy in mouse ...
Fibroblast stromal support model for predicting human papillomavirus-associated cancer drug responses [0.03%]
用于预测人类乳头瘤病毒相关癌症药物反应的成纤维细胞间质支持模型
Claire D James,Rachel L Lewis,Alexis L Fakunmoju et al.
Claire D James et al.
Currently, there are no specific antiviral therapeutic approaches targeting Human papillomaviruses (HPVs), which cause around 5% of all human cancers. Specific antiviral reagents are particularly needed for HPV-related oropharyngeal cancers...
A cGAS-mediated type I interferon response in human CD4+ T cells depends on productive infection and is conserved over HIV types and strains [0.03%]
人类CD4+T细胞中由cGAS介导的一型干扰素反应依赖于感染的产生，并且在不同类型的HIV毒株之间具有保守性
Marija Janevska,Timothy Cammaert,Evelien Naessens et al.
Marija Janevska et al.
Human immunodeficiency virus (HIV) type 2 is known to be less pathogenic than HIV-1, possibly due to more effective immune control mechanisms. The mechanism of innate sensing of HIV-2 by T cells is at present unclear. In this study, we show...
SARS-CoV-2 infection perturbs the gastrointestinal tract and induces modest microbial translocation across the intestinal barrier [0.03%]
新冠病毒感染扰动胃肠道并诱导肠道屏障轻微的微生物移位
Kelsie Brooks,Christine E Nelson,Cynthia Aguilar et al.
Kelsie Brooks et al.
SARS-CoV-2 infects via the respiratory tract, but COVID-19 includes an array of non-respiratory symptoms, among them gastrointestinal (GI) manifestations such as vomiting and diarrhea. Here we investigated the GI pathology of SARS-CoV-2 inf...