Architectural organization and in situ fusion protein structure of lymphocytic choriomeningitis virus [0.03%]
淋巴细胞脉络丛脑膜炎病毒的建筑组织和原位融合蛋白结构
Joon S Kang,Kang Zhou,Hui Wang et al.
Joon S Kang et al.
Arenaviruses exist globally and can cause hemorrhagic fever and neurological diseases, exemplified by the zoonotic pathogen lymphocytic choriomeningitis virus (LCMV). The structures of individual LCMV proteins or their fragments have been r...
Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and viral protein 2C-mediated replication complex formation [0.03%]
硬脂酰辅酶A脱氢酶1(SCD1)通过调节宿主细胞脂质代谢和病毒蛋白2C介导的复制复合物的形成调控口蹄疫病毒复制
Bonan Lv,Yuncong Yuan,Zhuang Yang et al.
Bonan Lv et al.
The life cycle of foot-and-mouth disease virus (FMDV) is tightly regulated by host cell lipid metabolism. In previous studies, we reported downregulated expression of stearoyl coenzyme A desaturase-1 (SCD1), a key enzyme of fatty acid metab...
WNV and SLEV coinfection in avian and mosquito hosts: impact on viremia, antibody responses, and vector competence [0.03%]
WNV和SLEV宿主的共同感染：对病毒血症、抗体反应及载体能力的影响
Emily N Gallichotte,Emily A Fitzmeyer,Landon Williams et al.
Emily N Gallichotte et al.
West Nile virus (WNV) and St. Louis encephalitis virus (SLEV) are closely related flaviviruses that can cause encephalitis in humans and related diseases in animals. In nature, both are transmitted by Culex, with wild birds, including jays,...
Headless hemagglutinin-containing influenza viral particles direct immune responses toward more conserved epitopes [0.03%]
无头血凝素流感病毒颗粒使免疫反应倾向于更稳定的表位
Cait E Hamele,Zhaochen Luo,Rebecca A Leonard et al.
Cait E Hamele et al.
Seasonal influenza vaccines provide mostly strain-specific protection due to the elicitation of antibody responses focused on evolutionarily plastic antigenic sites in the hemagglutinin head domain. To direct the humoral response toward mor...
Human rhinovirus 16 induces an ICAM-1-PKR-ATF2 axis to modulate macrophage functions [0.03%]
人鼻病毒16型诱导ICAM-1-PKR-ATF2轴调节巨噬细胞功能
Suzanne Faure-Dupuy,Manon Depierre,Zoé Fremont-Debaene et al.
Suzanne Faure-Dupuy et al.
Human rhinovirus (HRV) infections are the leading cause of disease exacerbations in individuals with chronic pulmonary diseases, primarily due to impaired macrophage functions, resulting in defective bacterial elimination. We previously dem...
Impact of VP2 structure on antigenicity: comparison of BTV1 and the highly virulent BTV8 serotype [0.03%]
VP2结构对抗原性的影响：BTV1与高毒力BTV8血清型的比较
Sara L Bissett,Polly Roy
Sara L Bissett
Bluetongue virus (BTV) is an agriculturally and economically significant insect-borne virus that causes serious illness and death in sheep and other domestic and wild ruminants in large areas of the world. Numerous BTV serotypes exist, and ...
Comparative Study
Journal of virology. 2024 Oct 22;98(10):e0095324. DOI:10.1128/jvi.00953-24 2024
Herpes simplex virus 1 inhibits phosphorylation of RNA polymerase II CTD serine-7 [0.03%]
单纯疱疹病毒1型抑制RNA聚合酶II CTD丝氨酸-7磷酸化
Adam W Whisnant,Oliver Dyck Dionisi,Valeria Salazar Sanchez et al.
Adam W Whisnant et al.
Transcriptional activity of RNA polymerase II (Pol II) is influenced by post-translational modifications of the C-terminal domain (CTD) of the largest Pol II subunit, RPB1. Herpes simplex virus type 1 (HSV-1) usurps the cellular transcripti...
High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains [0.03%]
基于高通量测序的中和实验揭示了重复免疫反应如何影响人H1N1流感病毒株的滴度
Andrea N Loes,Rosario Araceli L Tarabi,John Huddleston et al.
Andrea N Loes et al.
The high genetic diversity of influenza viruses means that traditional serological assays have too low throughput to measure serum antibody neutralization titers against all relevant strains. To overcome this challenge, we developed a seque...
Translation of HIV-1 unspliced RNA is regulated by 5' untranslated region structure [0.03%]
HIV-1未拼接RNA的翻译受到5'-非翻译区结构调节
Zetao Cheng,Saiful Islam,Joseph G Kanlong et al.
Zetao Cheng et al.
HIV-1 must generate infectious virions to spread to new hosts and HIV-1 unspliced RNA (HIV-1 RNA) plays two central roles in this process. HIV-1 RNA serves as an mRNA that is translated to generate proteins essential for particle production...