Interferon-induced miR-7705 modulates the anti-virus activity of cholesterol 25-hydroxylase [0.03%]
干扰素诱导产生的miR-7705通过调节胆固醇25-羟基化酶的抗病毒活性来抑制RNA病毒入侵
Le Wang,Hongxiao Song,Fengchao Xu et al.
Le Wang et al.
Cholesterol 25-hydroxylase (CH25H), an interferon-stimulated gene (ISG), has been implicated in broad-spectrum antiviral immunity. Here, we identify CH25H as a potent suppressor of hepatitis B virus (HBV) replication that significantly outp...
Mutations in feline infectious peritonitis virus nonstructural protein 14/16 methyltransferase attenuate the pathogenicity of the virus in cats [0.03%]
猫传染性腹膜炎病毒非结构蛋白14/16甲基转移酶突变可降低病毒在猫中的致病性
Zhe Jiao,Jia Li,Pengpeng Wang et al.
Zhe Jiao et al.
Feline infectious peritonitis virus (FIPV) can cause an immune-mediated disease that is fatal to felines, but there is a lack of clinically effective protection conferred by vaccines. The methyltransferase (MTase) activity of the coronaviru...
Limiting viral replication in hematopoietic cells delays Rift Valley fever virus disease progression in C57BL/6 mice [0.03%]
在C57BL/6小鼠中限制造血细胞中的病毒复制可延缓裂谷热病毒病的进展
Lingqing Xu,Alden C Paine,Dominique J Barbeau et al.
Lingqing Xu et al.
Rift Valley fever virus (RVFV) causes mild to severe disease in livestock and humans. It was first identified in 1931 during an epizootic in Kenya and has spread across Africa and into the Middle East. Hematopoietic cells are one of the maj...
Genomic characterization of arboviruses discovered between the 1950s and 1980s [0.03%]
20世纪50至80年代发现的节肢动物传递病毒的基因组特征
Ingra M Claro,Xinyi Hua,Ashley Viveros et al.
Ingra M Claro et al.
Arthropod-borne viruses (arboviruses) pose a major threat to global public health, impacting both human and animal health. Genomic characterization is important for arboviruses because it allows for an understanding of their evolution and i...
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5 [0.03%]
锌指抗病毒蛋白ZNF33B通过控制HSPB1/8介导的日本脑炎病毒结构蛋白5SUMO化促进日本脑炎病毒感染
Jian Du,Chunwei Li,Jinyan Zhang et al.
Jian Du et al.
Japanese encephalitis virus (JEV) is a significant flavivirus that poses a threat to public health, as it induces encephalitis in humans and reproductive disorders in sows. We have recently identified that zinc finger protein 33B (ZNF33B) i...
Continuous evolution of Eurasian avian-like H1N1 swine influenza viruses with pdm/09-derived internal genes enhances pathogenicity in mice [0.03%]
带有pdm / 09内部基因的欧亚类禽H1N1猪流感病毒的连续进化增强了其在小鼠中的致病性
Riguo Lan,Jizhe Yang,Jixiang Li et al.
Riguo Lan et al.
Swine influenza A virus (swIAV) is an important zoonotic pathogen with the potential to cause human influenza pandemics. Swine are considered "mixing vessels" for generating novel reassortant influenza A viruses. In 2009, a swine-origin rea...
Effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by Culex mosquitoes and pathogenesis in a vertebrate host [0.03%]
CpG和UpA二核苷酸增加对西尼罗病毒基因组、病毒介由库蚊传播及适应脊椎动物宿主能力的影响
Joyce W M van Bree,Imke Visser,Eleanor M Marshall et al.
Joyce W M van Bree et al.
Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein-coding RNA. ...
Influenza A virus circumvents the innate immune response through the sequestration of double-stranded RNA [0.03%]
甲型流感病毒通过结合双链RNA绕过先天性免疫反应
Masahiro Nakano,Sho Miyamoto,Chiho Ohnishi et al.
Masahiro Nakano et al.
Double-stranded RNA (dsRNA), which induces an innate immune response against viral infections, is rarely detected in influenza A virus (IAV)-infected cells. Nevertheless, we previously reported that the influenza A viral ribonucleoprotein (...
Phenylbutyrate restricts murine β-coronavirus infectivity and limits virus-induced demyelination in vivo [0.03%]
苯丁酸可限制鼠β冠状病毒的感染并降低病毒诱导的脱髓鞘作用
Grishma Kasle,Madhav Sharma,Saurav Kumar et al.
Grishma Kasle et al.
High morbidity and mortality associated with human β-coronavirus (CoV) infection highlight the need to determine host responses to infection and develop anti-viral therapies. Gap junction intercellular communication (GJIC), particularly in...
Hepatitis C virus modified SE2F442NYT-mRNA-LNP candidate vaccine promotes helper CXCR5+T cells [0.03%]
经基因改良的SE2F442NYT-mRNA-LNP肝炎C病毒疫苗候选疫苗可促进辅助CXCR5+t细胞产生
Yuki Haga,Preedia Babu E,Marzena Swiderska-Syn et al.
Yuki Haga et al.
T cells play an important role in initiating antibody responses by instructive signals of cell-cell contacts and secretion of soluble cytokines as mediators. We investigated the role of the modified soluble E2 (sE2F442NYT) antigen from hepa...