An orally available 4 '-fluorouridine prodrug inhibits SFTSV and LCMV infection [0.03%]
一种口服有效的4'-氟尿苷前药可抑制SFTSV和LCMV感染
Xiaoqin Jian,Tianwen Hu,Huan Xu et al.
Xiaoqin Jian et al.
Bunyaviruses, a subset of segmented negative-sense RNA viruses, include pathogenic species capable of zoonotic transmission to humans via arthropod vectors and rodent hosts. Pathogenic bunyavirus infections can cause severe hemorrhagic feve...
High seroprevalence and high risk: why are older adults more prone to respiratory syncytial virus? [0.03%]
高血清阳性率和高风险：为何老年人更容易感染呼吸道合胞病毒？
Piotr Rzymski,Barbara Poniedziałek,Dorota Zarębska-Michaluk et al.
Piotr Rzymski et al.
Despite widespread seropositivity, respiratory syncytial virus (RSV) remains a major cause of severe illness in adults aged 60 years and older. This review examines why infection-acquired immunity fails to protect this group, focusing on fo...
Positive correlation between structural disorder of the HIV-1 Gag N-terminal segment and progeny virus particle formation [0.03%]
HIV-1 Gag N端片段结构无序度与子代病毒颗粒形成正相关
Takaaki Koma,Osamu Kotani,Keisuke Kamba et al.
Takaaki Koma et al.
A class of unstructured peptide segments termed disordered regions plays a crucial role in the regulation of protein structure and function. Although the N-terminal region of the matrix (MA) domain of the HIV-1 Gag precursor protein is comp...
Human guanylate-binding protein (GBP) 1 inhibits replication of severe acute respiratory syndrome coronavirus 2 [0.03%]
人源性鸟苷酸结合蛋白(GBP)1抑制新型冠状病毒复制
Rubaiyea Farrukee,Francesca Mordant,Charley Mackenzie-Kludas et al.
Rubaiyea Farrukee et al.
Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are associated with significant morbidity and mortality worldwide. Identification and characterization of intracellular proteins with antiviral activity (known as restriction...
Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease [0.03%]
SARS-CoV-2主要蛋白酶催化二联体罕见扭曲的高效共价抑制剂的发现
Juan Wang,Xiaohong Sang,Wenyan Zheng et al.
Juan Wang et al.
Proteases are versatile therapeutic targets for a wide variety of human diseases, including cancer, cardiovascular diseases, and infections by viruses, bacteria, and parasites. The main protease (Mpro) of severe acute respiratory syndrome c...
Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production [0.03%]
人疱疹病毒6B型U65蛋白与组蛋白结合并抑制I型干扰素产生
Haokun Li,Hirohito Ogawa,Da Teng et al.
Haokun Li et al.
Human herpesvirus 6B (HHV-6B), a member of the Betaherpesvirinae subfamily, is a T-lymphotropic virus that causes exanthem subitum and has been implicated in neuroinflammatory conditions such as multiple sclerosis. The tegument proteins, wh...
Sensing of Ebinur Lake virus by distinct pattern recognition receptors dictates cell-type specific innate immunity and pathogenesis [0.03%]
不同的模式识别受体对艾比努尔湖病毒的感应决定先天免疫和发病机制的细胞类型特异性
Jia-Peng Zou,Su-Yun Wang,Han Xia et al.
Jia-Peng Zou et al.
Ebinur Lake virus (EBIV) is a recently identified orthobunyavirus with broad host range and zoonotic potential, posing a public health risk. However, the mechanisms underlying EBIV pathogenesis and host innate immune responses remain unclea...
A novel accessory gene product of tick-borne Dhori-Orthomyxovirus, encoded by overlooked spliced transcripts of RNA segment 6 [0.03%]
由被忽视的RNA片段6跳跃剪接转录本编码的新型宿主因子 Dhori-正链病毒属病毒的辅助基因产物
E Bendl,G Lampo,P Chlanda et al.
E Bendl et al.
Dhori virus (DHOV) (Orthomyxoviridae, genus: Thogotovirus) is a tick-borne virus with a segmented, negative-sense RNA genome. Thogotoviruses can be divided into two clades, Thogoto-like and Dhori-like viruses, which differ in their coding s...
CSAD inhibits excessive inflammation during viral infections through the NF-κB signaling pathway [0.03%]
CSAD通过NF-κB信号通路抑制病毒感染过程中的过度炎症反应
Yufan Zhang,Xiaotian Yang,Yun Chen et al.
Yufan Zhang et al.
Studies have shown that 129 mice generate more severe inflammatory responses than C57BL/6 (B6) mice shortly after influenza virus infection. However, the mechanisms for regulation of the magnitudes and kinetics of innate immune responses in...
Retraction for Saeed et al., "Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner" [0.03%]
Saeed等人的“Parvulin 14和Parvulin 17与HBx和cccDNA结合，并以HBx依赖的方式从cccDNA到病毒体上调乙肝病毒复制”的撤稿声明
Umar Saeed,Jumi Kim,Zahra Zahid Piracha et al.
Umar Saeed et al.