The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues [0.03%]
血凝素蛋白第1谱系和2.3.4.4b谱系H5N1高致病性禽流感病毒对禽类和哺乳动物组织具有相似的吸附模式
Bingkuan Zhu,Kevin Fung,Hailey Huiyi Feng et al.
Bingkuan Zhu et al.
The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses has been accompanied by an expanded host range and the establishment of sustained viral transmission among dairy cattle. To evalua...
LPS/TLR4-activated M1-polarized macrophage-derived exosomes enhance IBV vaccine efficacy in chickens [0.03%]
LPS/TLR4激活的M1极化巨噬细胞源性外泌体能增强鸡IBV疫苗效力
Jun Zhou,Shikai Cai,Hongbin Huang et al.
Jun Zhou et al.
Infectious bronchitis virus (IBV) imposes substantial economic losses on poultry production due to extensive serotypic diversity and limited cross-protection conferred by conventional vaccines. This study evaluated exosomes derived from M1-...
Hepatitis C virus NS3/4A protease cleaves SPG20, a key regulator of lipid droplet turnover, to promote lipid droplet formation [0.03%]
丙型肝炎病毒NS3/4A蛋白酶通过切割SPG20促进脂滴生成以抑制脂滴周转
Chieko Matsui,Putu Yuliandari,Lin Deng et al.
Chieko Matsui et al.
Hepatitis C virus (HCV) assembles in close proximity to lipid droplets (LDs), which play important roles in HCV RNA replication. HCV infection often causes the accumulation of large LDs in hepatocytes. However, the molecular mechanism under...
Crimean-Congo hemorrhagic fever virus Africa 1 lineage in Hyalomma species ticks, Tunisia, 2024 [0.03%]
2024年突尼斯非洲1型克里米亚-刚果出血热病毒在Hyalomma蜱属蜱虫中的发现
Silvia Fabi,Giuseppe Di Pietra,Elisabetta Valente et al.
Silvia Fabi et al.
Prediction of COVID-19 disease progression by multiparametric analysis of circulating extracellular vesicles with flow cytometry [0.03%]
基于流式细胞术的循环细胞外囊泡多参数分析预测COVID-19疾病进展
Evelyn Hammer,Charlotte Flynn,Johannes Rößler et al.
Evelyn Hammer et al.
Extracellular vesicles (EVs) are released from all cells of the body. They are considered to mirror the state of the cells from which they are released and circulate in the blood, suggesting a possible use of EV analysis for diagnostic purp...
Baculovirus 25K hijacks host UAP56 to facilitate nuclear export of viral mRNA in insect cells [0.03%]
家蚕杆状病毒利用宿主UAP56蛋白促进病毒mRNA在昆虫细胞核内的转运及输出
Sixuan Xiao,Huizhen Guo,Jiayi Liu et al.
Sixuan Xiao et al.
Bombyx mori nucleopolyhedrovirus (BmNPV) is a baculovirus that hijacks host genes to cause viral infections. UAP56 is highly conserved in different species. Previous studies have shown that UAP56 is involved in several viral infections. How...
Sources and sinks of influenza A virus genomic diversity in swine from 2009 to 2022 in the United States [0.03%]
2009-2022年美国猪流感A病毒基因组多样性的来源和汇款地点分析
Garrett M Janzen,Blake T Inderski,Jennifer Chang et al.
Garrett M Janzen et al.
Influenza A virus (IAV) in swine in the U.S. is surveilled to monitor genetic evolution to inform intervention efforts and aid pandemic preparedness. We describe data from the U.S. Department of Agriculture National Surveillance Plan for In...
Human metapneumovirus: understanding the molecular mechanisms and pathology of infection [0.03%]
人副流感病毒:理解感染的分子机制和病理学
Chase J Heim,Bernadette G van den Hoogen,Rebecca E Dutch
Chase J Heim
Human metapneumovirus (HMPV) is a common and globally prevalent respiratory virus that can cause clinical symptoms ranging from mild respiratory illness to severe bronchiolitis and pneumonia, with substantial morbidity and mortality. HMPV a...
Natural killer cells and IFN-γ protect against liver injury during HAV infection in mice [0.03%]
自然杀伤细胞和干扰素-γ可通过阻止HAV感染小鼠时的肝损伤而产生保护作用
Ichiro Misumi,You Li,Takayoshi Shirasaki et al.
Ichiro Misumi et al.
A limited number of studies on human subjects with type-A hepatitis have found a positive correlation between activated natural killer (NK) cell frequencies in blood and the severity of liver injury. However, without knowledge of difference...
MERS-CoV and SARS-CoV-2 infection in diverse human lung organoid-derived cultures [0.03%]
不同的人类肺器官样衍生培养物中MERS-CoV和SARS-CoV-2的感染
Kim Lam Chiok,Kristof Jenik,Mark Fenton et al.
Kim Lam Chiok et al.
Cell cultures are widely used to study infectious respiratory diseases and to test therapeutics; however, they do not faithfully recapitulate the architecture and complexity of the human respiratory tract. Lung organoids have emerged as an ...