Paul Gendler,Arturo Barbachano-Guerrero,Samuel D Chappell et al.
Paul Gendler et al.
There are an unknown number of sylvatic ("sylvan" = "of the forest") dengue viruses currently being sustained by nonhuman primates and mosquitoes in the forests of Africa and Asia. Humans are regularly infected with these viruses, occasiona...
Applications and limitations of the passenger hypothesis for HIV reservoir persistence and cure [0.03%]
乘客假说在HIV储存库维持和治愈中的应用及局限性
Joshua T Schiffer,Joseph C Mudd,Annukka A R Antar et al.
Joshua T Schiffer et al.
Antiretroviral therapy (ART) suppresses HIV replication in people living with HIV (PWH), but a persistent population of reservoir cells prevents cure. Reservoir cells are mostly anatomically dispersed, latently infected CD4+ T cells harbori...
A replicating recombinant vesicular stomatitis virus model for dairy cattle H5N1 influenza virus glycoprotein evolution [0.03%]
一种用于乳牛H5N1流感病毒糖蛋白进化的复制型重组-vesicular stomatitis病毒模型
Lindsey R Robinson-McCarthy,Kylie E Zirckel,Holly C Simmons et al.
Lindsey R Robinson-McCarthy et al.
A panzootic of highly pathogenic avian influenza (HPAI) H5N1 viruses from clade 2.3.4.4b has triggered a multistate outbreak in US dairy cattle and an unknown number of human infections. HPAI viruses are handled in specialized biocontainmen...
TRIM56 enhances adenoviral E1A steady state to improve oncolytic adenovirus therapy efficacy [0.03%]
TRIM56通过增强腺病毒E1A的稳定表达来提高溶瘤腺病毒的疗效
Nan Sun,Jikai Zhang,Chen Zhang et al.
Nan Sun et al.
Oncolytic adenoviruses (OAVs) engineered to carry antitumor or immune-activating transgenes are being actively explored for cancer immunotherapy. While many efforts have focused on modifying OAVs to counteract the immunosuppressive tumor mi...
VCY mediates inhibition of PFV replication via interaction with the transcription activator Tas [0.03%]
VCY通过与转录激活因子Tas的相互作用抑制PFV复制
Lin Jiang,Chunhua Han,Junshi Zhang et al.
Lin Jiang et al.
Prototype foamy viruses (PFVs) are complex retroviruses that establish long-term latent infections in hosts without causing disease, positioning them as potential safe gene transfer vectors. Understanding the host proteins involved in PFV r...
Hannah M Schmidt,Grace C Sorensen,Matthew R Lanahan et al.
Hannah M Schmidt et al.
Post-translational modifications play crucial roles in regulating viral infections, yet roles for many modifications remain unexplored in orthoflavivirus biology. Here, we demonstrate that the UFMylation system, a post-translational modific...
The role of immune checkpoint molecules in PRRSV-2-induced immune modulation: insights from comparative in vivo evaluation including NADC34-like PRRSV [0.03%]
PRRSV-2诱导的免疫调控中免疫检查点分子的作用：包括NADC34样病毒在内的体内比较评估的新见解
Seung-Chai Kim,Hwan-Ju Kim,Sang Chul Kang et al.
Seung-Chai Kim et al.
The emergence of genetically diverse PRRSV-2 lineages, including the NADC34-like virus, presents significant challenges to the swine industry due to their variable pathogenicity and impact on immune modulation. However, the precise mechanis...
COP I vesicles facilitate classical swine fever virus proliferation by transporting fatty acid synthase from the Golgi apparatus to the endoplasmic reticulum [0.03%]
巨胞饮小体通过将高尔基体的脂肪酸合成酶运输到内质网从而促进猪瘟病毒的增殖
Liang Zhang,Tao Wang,Chen Chen et al.
Liang Zhang et al.
Classical swine fever virus (CSFV) is an enveloped, positive-sense, single-stranded RNA virus in the Flaviviridae family that remodels the cell's endomembrane for its own propagation. The early secretory pathway is exploited by viruses for ...
Brittany Seibert,C Joaquin Caceres,L Claire Gay et al.
Brittany Seibert et al.
Airborne transmission is an essential mode of infection and spread of influenza viruses among humans. However, most studies use liquid inoculum for virus infection. To better replicate natural airborne infections in vitro, we generated a ca...
Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase [0.03%]
发现一种非核苷抑制剂并将其结合到呼吸道合胞病毒RNA依赖性RNA聚合酶的手掌结构域新位点中
Jay H Kalin,Yanting Yin,Minh T Tran et al.
Jay H Kalin et al.
Respiratory syncytial virus (RSV) is a major cause of severe respiratory tract infections in infants, young children, and the elderly. We report herein the discovery and characterization of a novel RSV polymerase (RSVpol) non-nucleoside inh...