Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution [0.03%]
长期连续传代SARS-CoV-2发现趋同演化标志物
Charles S P Foster,Gregory J Walker,Tyra Jean et al.
Charles S P Foster et al.
Understanding viral evolutionary dynamics is crucial to pandemic responses, prediction of virus adaptation over time, and virus surveillance for public health strategies. Whole-genome sequencing (WGS) of severe acute respiratory syndrome co...
Rapid reconstruction of infectious bronchitis virus expressing fluorescent protein from its nsp2 gene based on transformation-associated recombination platform [0.03%]
基于转化关联重组平台的新型传染性支气管炎病毒荧光蛋白快速重建体系
Yingfei Li,Linqing Duan,Lihua Tang et al.
Yingfei Li et al.
Traditional reverse genetics strategies for large-genome RNA viruses are hindered by multiple technical bottlenecks, including dependence on specific restriction enzyme sites, cumbersome multi-step cloning, and genetic instability of oversi...
Heat shock protein 90 chaperone activity is required for hepatitis A virus replication [0.03%]
热休克蛋白90伴侣活性对甲型肝炎病毒复制是必需的
You Li,Xin Zheng,Ling Xie et al.
You Li et al.
HSP90 heat shock chaperones are essential for maintaining cellular proteostasis, as well as the ATP-dependent folding and functional maturation of many viral proteins. As a result, inhibitors of HSP90 have broad antiviral activity, disrupti...
Kaposi's sarcoma-associated herpesvirus ORF61 protein sequesters APOBEC3B in filamentous aggregates [0.03%]
柯萨奇病毒ORF61蛋白将APOBEC3B固定在丝状聚集物中
Laura-Marie Luoto,Enrico Caragliano,Carola Schneider et al.
Laura-Marie Luoto et al.
Herpesviruses are large DNA viruses that encode homologs of cellular enzymes. The viral ribonucleotide reductase, which consists of large R1 and small R2 subunits, is required for deoxyribonucleotide synthesis. However, herpesviruses have r...
Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies [0.03%]
来自英国两大研究的人类疱疹病毒6型染色体整合的遗传变异、地区差异及其与胸痛的关系及两种古老毒株祖先的识别
Michael L Wood,Adam J Bell,Robin Young et al.
Michael L Wood et al.
Tens of millions of people worldwide have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), yet we know little about the consequences. iciHHV-6-positive individuals inherit the genome of HHV-6A or HHV-6B in the germline, an...
Trim7 does not have a role in the restriction of murine norovirus infection in vivo [0.03%]
Trim7不对鼠诺如病毒感染的限制产生作用
Mridula Annaswamy Srinivas,Linley R Pierce,Mikayla C Olson et al.
Mridula Annaswamy Srinivas et al.
Trim7 is an E3 ubiquitin ligase that was recently identified as a central regulator of host-viral interactions with both pro-viral and anti-viral activity in cell culture. As an inhibitor, Trim7 overexpression ubiquitinates viral proteins b...
Interferon-stimulated gene MCL1 inhibits foot-and-mouth disease virus replication by modulating mitochondrial dynamics and autophagy [0.03%]
干扰素诱导基因MCL1通过调节线粒体动力学和自噬抑制口蹄疫病毒增殖
Aishwarya Mogulothu,Danielle Hickman,Sarah Attreed et al.
Aishwarya Mogulothu et al.
Interferons (IFNs) and the IFN-stimulated genes (ISGs) that they induce are effective in reducing the replication of foot and mouth disease virus (FMDV). The use of a high-throughput ISG screen identified the ISG myeloid cell leukemia 1 (MC...
SARS-CoV-2 infection enhancement by amphotericin B: implications for disease management [0.03%]
两性霉素B通过增强SARS-CoV-2感染影响疾病预后及其机制研究
Dung Nguyen,Stephen M Laidlaw,Xiaofeng Dong et al.
Dung Nguyen et al.
Severe coronavirus disease 2019 (COVID-19) patients who require hospitalization are at high risk of invasive pulmonary mucormycosis. Amphotericin B (AmB), which is the first-line therapy for invasive pulmonary mucormycosis, has been shown t...
A group of segmented viruses contains genome segments sharing homology with multiple viral taxa [0.03%]
一类分段基因组病毒的基因组片段与多种病毒类群同源
Huang Huang,Zhongmei Zhang,Xidan Pang et al.
Huang Huang et al.
The discovery of diverse segmented RNA viruses through metatranscriptomics has enabled researchers to trace their evolutionary trajectories. However, this effort has been hindered by the limited availability of complete genome sequences and...
Quantifying the zoonotic risk profile of European influenza A viruses in swine from 2010 to 2020 inclusive [0.03%]
2010年至2020年欧洲猪流感病毒的跨物种传播风险量化分析
Amelia Coggon,Sara Lopes,Gaëlle Simon et al.
Amelia Coggon et al.
H1 and H3 influenza A viruses (IAVs) circulating in European pigs are markedly distinct from those circulating in other global swine populations. These viruses exhibit significant genetic diversity, further expanded by periodic interspecies...