Cellular miRNAs and viruses: trends in miRNA sequestering and target de-repression [0.03%]
细胞源miRNA和病毒：miRNA隔离与靶点去抑制的趋势分析
Bonita H Powell,Kenneth W Witwer,Mollie K Meffert
Bonita H Powell
Altered gene regulation downstream of infection has been linked to devastating cancers and neurological diseases, highlighting the importance of understanding viral:host gene interactions. Historically, approaches based on bioinformatic bin...
UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation [0.03%]
UNC0638通过抑制猫科天冬氨酸蛋白酶L成熟来阻止SARS-CoV-2进入细胞
Yongjun Chen,Yujin Shi,Xiaoyan Zuo et al.
Yongjun Chen et al.
Since the outbreak of SARS-CoV-2, viral mutations have posed significant challenges in identifying therapeutic targets and developing broad-spectrum antiviral drugs. Post-translational modifications of genes involved in interferon productio...
In vitro and in vivo characterization of a bat merbecovirus with ACE2- and DPP4-independent cell entry [0.03%]
一种不依赖ACE2和DPP4进入细胞的蝙蝠merbecovirus的体外和体内表征
Hiromichi Matsugo,Tomoya Kitamura,Naohiro Takahashi et al.
Hiromichi Matsugo et al.
Betacoronaviruses, which have caused three human outbreaks within the last two decades, are thought to originate from bats, raising the concern that bat coronaviruses could cause a novel human outbreak in the future. To determine whether th...
Mimivirus transcription and translation occur at well-defined locations within amoeba host cells [0.03%]
巨噬细胞病毒的转录和翻译发生在amoeba宿主细胞内的特定位置
Lotte Mayer,Georgi Nikolov,Martin Kunert et al.
Lotte Mayer et al.
Many giant viruses replicate in the cytoplasm in viral factories. How exactly these viral factories are established and where the different steps of the replication cycle occur remain largely obscure. We have developed a single-molecule mes...
Design of SARS-CoV-2 RBD immunogens to focus immune responses toward conserved coronavirus epitopes [0.03%]
设计针对冠状病毒保守表位的SARS-CoV-2 RBD免疫原以聚焦免疫反应
Caitlin Harris,A Brenda Kapingidza,James E San et al.
Caitlin Harris et al.
SARS-CoV-2 continues to evolve, with new variants emerging that evade pre-existing immunity and limit the efficacy of existing vaccines. One approach toward developing superior, variant-proof vaccines is to engineer immunogens that preferen...
MARCH6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradation [0.03%]
MARCH6通过TOLLIP介导的选择性自噬降解抑制病毒NS5蛋白的复制
Peng Zhou,Wanrong Wu,Jiani Wei et al.
Peng Zhou et al.
The E3 ligase membrane-associated RING finger 6 (MARCH6) plays a pivotal role in various cellular processes; however, its role in viral defense remains largely unexplored. In this study, we have elucidated a novel antiviral mechanism of avi...
Host origin is a determinant of coevolution between gene segments of avian H9 influenza viruses [0.03%]
宿主来源决定禽H9流感病毒基因片段的协同进化关系
Jennifer E Jones,Seema S Lakdawala
Jennifer E Jones
Several emerging influenza viruses, including H7N9 and H5N6 viruses, trace their origins to reassortment with H9N2 viruses that contributed internal gene segments. However, the evolutionary constraints governing the reassortment of H9N2 vir...
Correction for Lv et al., "Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model" [0.03%]
对Lv等人的“甲型流感H1N1血凝素和神经氨酸酶在小鼠模型中的不同抗原印迹效应”的更正通知
Huibin Lv,Qi Wen Teo,Chang-Chun D Lee et al.
Huibin Lv et al.
Published Erratum
Journal of virology. 2025 Jun 12:e0078325. DOI:10.1128/jvi.00783-25 2025
Correction for Gurda et al., "Mapping a Neutralizing Epitope onto the Capsid of Adeno-Associated Virus Serotype 8" [0.03%]
更正：古尔达等人的“腺相关病毒8型衣壳上中和表位的定位”一文
Brittney L Gurda,Christina Raupp,Ruth Popa-Wagner et al.
Brittney L Gurda et al.
Published Erratum
Journal of virology. 2025 Jun 12:e0079225. DOI:10.1128/jvi.00792-25 2025
GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses [0.03%]
GSDMD和GSDME在肠道冠状病毒PDCoV诱导的细胞焦亡及炎症反应中发挥不同作用
Chenyu Li,Yuting Shi,Chunying Xie et al.
Chenyu Li et al.
Porcine deltacoronavirus (PDCoV), an emerging enteric coronavirus with zoonotic potential, typically causes intestinal villous epithelial cell damage with inflammation. Pyroptosis is a recently identified inflammatory form of programmed cel...