CD4-mimetics sensitize HIV-infected cells to ADCC mediated by plasma from persons with early-stage HIV-1 infection [0.03%]
CD4模拟物可使HIV感染细胞对早期HIV-1感染者血浆介导的抗体依赖性细胞毒性作用敏感
Shilei Ding,Alexandra Tauzin,Delia Pinto-Santini et al.
Shilei Ding et al.
The viral reservoir in long-lived memory CD4+ cells, established in the early stages of HIV infection, represents the main obstacle to an HIV cure. Some strategies being developed to target the reservoir rely on rendering HIV-1 envelope gly...
Single-cell RNA sequencing reveals hemocyte heterogeneity, differentiation trajectories, and viral tropism in shrimp (Macrobrachium rosenbergii) infected with decapodiridovirus litopenaeus1 [0.03%]
单细胞RNA测序揭示了感染裂解性病毒的对虾（马来西亚淡水虾）血细胞异质性、分化轨迹及嗜性定植特点
Bang Xiao,Fang Kang,Taolin Fan et al.
Bang Xiao et al.
Decapodiridovirus litopenaeus1 (DIV1) is a highly pathogenic virus threatening crustacean aquaculture. Hemocytes, the primary immune cells in shrimp, play crucial roles in host defense, yet their transcriptional heterogeneity and differenti...
Melanie N Tripp,Stephen M Rawlinson,Sarah J Edwards et al.
Melanie N Tripp et al.
The Henipavirus genus comprises five viral species, of which the prototype members, Hendra virus (HeV) and Nipah virus (NiV), are reported to infect humans. In humans and other spill-over hosts, HeV/NiV can cause severe respiratory and/or e...
Development of DNA and mRNA-LNP vaccines against an H5N1 clade 2.3.4.4b influenza virus [0.03%]
针对H5N1 2.3.4.4b谱系流感病毒的DNA和mRNA-LNP疫苗的研发
Rebecca A Leonard,M Ariel Spurrier,Samantha Skavicus et al.
Rebecca A Leonard et al.
Effective vaccines are an important public health tool which may be needed to combat the emerging, highly pathogenic H5N1 avian influenza viruses currently circulating in cattle and poultry in the United States. While nucleic acid-based vac...
Rationally designed self-assembled peptide nanofibers provoke robust humoral immunity against nervous necrosis virus [0.03%]
理性设计的自组装肽纳米纤维可诱发针对神经坏死病毒的强力体液免疫响应
Chen Zhang,Yong-Can Zhou,Wen-Ye Song et al.
Chen Zhang et al.
Nervous necrosis virus (NNV) poses devastating mortality risks to almost all marine fish, causing significant economic losses to the marine fish aquaculture industry, particularly in juvenile groupers. However, no effective NNV vaccine is a...
Breadth of antibody activity elicited by an influenza B hemagglutinin vaccine is influenced by pre-existing immune responses to influenza B viruses [0.03%]
一种流感B型血凝素疫苗的抗体活性受试者既往感染的流感B病毒免疫反应的影响
Michael A Carlock,Spencer R Pierce,Ted M Ross
Michael A Carlock
Most people are exposed to influenza A and influenza B viruses (IBV) at an early age through natural infection or vaccination. These previous exposures can shape future immune responses and the ability to either recall memory B cells or gen...
A novel aptamer-based dNTP assay reveals that intact HIV virions are highly stable and do not contain enough dNTPs to support DNA synthesis [0.03%]
一种新型的以适配子为基础的dNTP测定法表明，完整的HIV病毒颗粒非常稳定，并且其中不含有足够的dNTP来支持DNA合成
Urja Biswas,Cynthia Bernal,Ruofan Wang et al.
Urja Biswas et al.
HIV virions contain high concentrations of IP6 (inositol hexakisphosphate), which stabilize capsids by binding to pores that allow dNTP to import into capsids during infection. The concentration of dNTPs in virions, however, is not known. T...
Teaching an old vector new tricks: the surprising versatility of AAV vaccines [0.03%]
教旧载体展现新招式：AAV疫苗的 surprising Versatility（腺相关病毒）疫苗的多才多艺之处
Stephen M Winston,Kristin B Wiggins,Stacey Schultz-Cherry et al.
Stephen M Winston et al.
Adeno-associated virus (AAV) has proven its clinical efficacy in the realm of gene therapy, resulting in seven FDA-approved gene therapies. While AAV gene transfer research has predominantly focused on its utility in monogenic disorders, AA...
The HCMV tegument protein UL88 degrades MyD88 and reduces innate immune activation [0.03%]
人巨细胞病毒蛋白UL88降解MyD88并降低先天性免疫活化
Rinki Kumar,Irene E Reider,Madison Martin et al.
Rinki Kumar et al.
The human cytomegalovirus (HCMV) encodes the tegument protein UL88, which supports virus spread by mediating the degradation of the innate immune signaling adapter protein, myeloid differentiation primary response 88 (MyD88). MyD88 transduc...
CX1/BtSY2 and BANAL-20-52 exhibit broader receptor binding and higher affinities to multiple animal ACE2 orthologs than SARS-CoV-2 prototype [0.03%]
CX1/BtSY2和BANAL-20-52与多种动物ACE2同源物的结合范围更广且亲和力高于SARS-CoV-2原型毒株
Zepeng Xu,Linjie Li,Yuhang Gu et al.
Zepeng Xu et al.
Animal coronaviruses (CoVs) CX1 (formerly named BtSY2) and BANAL-20-52 are phylogenetically closely related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and CX1 is the first observed animal betaCoV carrying naturally occ...