Pseudorabies virus induces natural killer cell depletion by GSDMD-mediated inflammation and pyroptosis to promote infection and lung injury [0.03%]
伪狂犬病毒通过GSDMD介导的炎症和细胞焦亡诱导自然杀伤细胞耗竭以促进感染和肺损伤
Jing Chen,Guangming Zhao,Yi Yang et al.
Jing Chen et al.
Pseudorabies virus (PRV) infection induces a hyperinflammatory response to promote inflammatory injury in multiple tissues. However, the relative mechanism remains elusive. Herein, we first confirmed that PRV infection could trigger pyropto...
The mRNA and protein of IL-8 oppositely regulate PRRSV replication via nucleoprotein and 14-3-3γ [0.03%]
IL-8的mRNA和蛋白通过核蛋白和14-3-3γ相反调节PRRSV复制
Yingchao Li,Jiaqi Liu,Dexin Li et al.
Yingchao Li et al.
Porcine reproductive and respiratory syndrome virus (PRRSV) has posed a significant threat to the global swine industry for over 3 decades, resulting in substantial economic losses. In this study, we identified the cellular protein 14-3-3γ...
Avian leukosis virus p15 interacts with interferon regulatory factor 7 to antagonize the cGAS-STING signaling pathway and promote viral replication [0.03%]
禽类 leukemia病毒p15与干扰素调节因子7相互作用以对抗cGAS-STING信号通路并促进病毒复制
Zhouhao Cui,Kui Shen,Moru Xu et al.
Zhouhao Cui et al.
Cyclic GMP-AMP synthase (cGAS) recognizes viral DNA within the cytoplasm and initiates innate antiviral response through the cGAS-STING pathway. However, viruses have evolved diverse strategies to counteract the cGAS-STING signaling pathway...
High genomic stability of Andes virus following successive passage in vivo in Syrian hamsters [0.03%]
秘鲁病毒在叙利亚仓鼠中连续传代后基因组稳定性高
Bryce M Warner,Jérémie Prévost,Nikesh Tailor et al.
Bryce M Warner et al.
Andes virus (ANDV) is a South American hantavirus that causes hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory infection with a case fatality rate as high as 40%. A critical model for studying HCPS is the Syrian hamster mode...
Kevin Busuttil,Nikéa Pittman,Jon Zachary et al.
Kevin Busuttil et al.
Oncolytic protoparvoviruses, including LuIII, H-1 parvovirus (H-1PV), and the prototypic strain of minute virus of mice (MVMp), can target and destroy cancer cells. Host cell targeting is based largely on the identification and interaction ...
Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses [0.03%]
结构和功能限制制约了与SARS-CoV-2相关的蝙蝠冠状病毒的激活及利用宿主蛋白酶进行细胞侵入的能力
Qingqing Li,Xiao Cai,Xiaoning Li et al.
Qingqing Li et al.
The persistent threat posed by SARS-CoV-2-related coronaviruses (SC2r-CoVs) in wildlife highlights the risk of zoonotic transmission. Cross-species infectivity is predominantly determined by spike (S) character and S-mediated cell entry. In...
Zuzana Vojtechova,Ruth Tachezy
Zuzana Vojtechova
Tumors of infectious origin globally represent 13%. Oncogenic DNA viruses such as human papillomavirus (HPV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV) are responsible for approximately 60% of these tumors. These oncoviruses are...
Frida E Sparaciari,Cadhla Firth,Erik A Karlsson et al.
Frida E Sparaciari et al.
Traditional food markets (TFMs) are dynamic and complex systems that play a vital role in societies across the globe. They provide fresh, affordable food, help preserve cultural traditions, and support the livelihoods of millions. However, ...
DENV-2 3'UTR dumbbell structure is a critical factor for viral infection and dissemination in Aedes mosquito [0.03%]
DENV-2 3' UTR哑铃结构是蚊媒病毒传播的关键因素
Xiaoyu Wang,Ying Huang,Fei Wang et al.
Xiaoyu Wang et al.
Dengue virus (DENV) is a mosquito-borne flavivirus with the capability of replicating and spreading between vertebrate and invertebrate hosts, which poses a huge threat to global public health. Understanding the molecular mechanism of its r...
Glucocorticoid receptor occupancy of key bovine alphaherpesvirus 1 (BoHV-1) promoters correlates with chromatin remodeling during reactivation from latency [0.03%]
糖皮质激素受体占据关键牛α疱疹病毒1型启动子与潜伏期重新激活期间染色质重塑相关性研究
Jeffery B Ostler,Clinton Jones
Jeffery B Ostler
Bovine alphaherpesvirus 1 (BoHV-1) continues to be a significant bovine pathogen. Acute infections culminate in lifelong latent infections in sensory neurons of trigeminal ganglia (TG) and the central nervous system. The synthetic corticost...