Validation of diverse and previously untraceable Sendai virus copyback viral genomes by direct RNA sequencing [0.03%]
通过直接RNA测序验证多样的和以前无法追踪的仙台病毒复制体病毒基因组
Sarah E Pye,Emna Achouri,Yanling Yang et al.
Sarah E Pye et al.
Copyback viral genomes (cbVGs) are truncated viral genomes with complementary ends produced when the negative-sense RNA virus polymerase detaches from the replication template and resumes elongation from the nascent strand. Despite advances...
Anellovirus constraint from 2 to 6 months postpartum followed by betatorquevirus and gammatorquevirus dominance in serum and milk [0.03%]
产后2至6个月血清和乳汁中环状病毒减少，随后贝塔和伽玛转角病毒占主导地位
Anne L Timmerman,Antonia L M Schönert,Martin Deijs et al.
Anne L Timmerman et al.
Anelloviruses are ubiquitous, diverse viruses in the human virome not causing disease. In adults, the anellovirus composition (anellome) is dominated by alphatorqueviruses. However, infants seem to acquire their first anellovirus infections...
Plasmid-like dynamics of persistent RNA viruses in the host fungal population [0.03%]
宿主真菌种群中持久性RNA病毒的质粒动力学性质
Yuto Chiba,Seiyo Watanabe,Ayano Ikeda et al.
Yuto Chiba et al.
Unlike the well-known acute or chronic animal and plant RNA viruses, most fungal RNA viruses (RNA mycoviruses) have a persistent life cycle. They lack an extracellular infection route and coexist with their hosts for a lifetime. RNA mycovir...
Meaghan H Hancock,Patrizia Caposio,Donna Collins-McMillen et al.
Meaghan H Hancock et al.
Human cytomegalovirus (HCMV) is a betaherpesvirus, which, like all herpesviruses, establishes a life-long latent infection while retaining the ability to reactivate its replicative program. While HCMV likely reactivates frequently and spora...
Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle [0.03%]
不同的冠状病毒Mac1突变体对ADP核糖结合和水解活性的影响表明其促进病毒复制周期的多个阶段
Joseph J O&#x;Connor,Anuradha Roy,Reem Khattabi et al.
Joseph J O&#x;Connor et al.
All coronaviruses (CoVs) encode a conserved macrodomain, termed Mac1, in non-structural protein 3 (nsp3) that binds and hydrolyzes ADP-ribose covalently attached to proteins. Mac1 is a key virulence factor that counters antiviral ADP-ribosy...
Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication [0.03%]
基于膜蛋白的CRISPR筛选鉴定到RPSA是猪流行性腹泻病毒复制所必需的宿主因子
Yu Zhao,Guanghao Guo,Yumei Sun et al.
Yu Zhao et al.
Porcine epidemic diarrhea, caused by porcine epidemic diarrhea virus (PEDV), is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets. The host factors required for PEDV replication, inclu...
Transferrin receptor 1 (TfR1) functions as an entry receptor for scale drop disease virus to invade the host cell via clathrin-mediated endocytosis [0.03%]
转铁蛋白受体1(TfR1)作为鳞脱落病病毒通过网格蛋白介导的胞吞作用侵入宿主细胞的受体发挥作用
Jiaming Chen,Yuting Fu,Yong Li et al.
Jiaming Chen et al.
Scale drop disease virus (SDDV), a distinct member of the genus Megalocytivirus within the Iridoviridae family, has emerged as a novel threat to global teleost aquaculture. Despite its importance, the pathogenic mechanism of SDDV remains la...
The vaccinia virus protein, C16, promotes the ubiquitylation and relocalization of the antiviral E3 ubiquitin-ligase, TRIM25 [0.03%]
痘病毒蛋白C16促进抗病毒E3连接酶TRIM25的泛素化再定位
Jianing Dong,Shu Yue Luo,Summer Smyth et al.
Jianing Dong et al.
Poxviruses co-opt the ubiquitin (Ub)-proteasome system (UPS) to facilitate virus replication, evade the innate immune response, and block programmed cell death of infected cells. Moreover, the UPS is an integral component of innate immune s...
Inhibition of interferon signaling improves rabbit calicivirus replication in biliary organoid cultures [0.03%]
干扰素信号传导的抑制可改善兔呼肠孤病毒在胆道类器官培养中的复制能力
Elena Smertina,Megan Pavy,Nias Y G Peng et al.
Elena Smertina et al.
The Rabbit hemorrhagic disease virus (RHDV) was discovered 40 years ago. This highly pathogenic virus threatens the integrity of ecosystems in the European rabbit's native range, while in Australia, it is used as a biocontrol tool to manage...
Influenza viral infection at the plasma membrane is restricted by lipid composition [0.03%]
血浆膜脂质组成限制流感病毒侵染
Steinar Mannsverk,Ana M Villamil Giraldo,Peter M Kasson
Steinar Mannsverk
Many enveloped viruses enter cells via fusion with the endosomal membrane, raising the question whether entry through the endosomal route confers a fitness advantage over fusion directly at the plasma membrane. We found that influenza A vir...