ASFV pE146L-induced ER remodeling is essential for viral replication [0.03%]
pE146L诱导的内质网重塑对非洲猪瘟病毒复制至关重要
Yilin Guo,Sai Niu,Xueying Wang et al.
Yilin Guo et al.
African swine fever virus (ASFV) causes a severe hemorrhagic disease, posing a significant threat to the global pig industry. Although the ASFV encodes nearly 200 proteins, the functions of many remain unknown. Here, we identify the inner e...
Single self-cleaving mRNA vaccine expressing multiple viral structural proteins elicits robust immune responses and protects nursing piglets against PDCoV infection [0.03%]
一种能自我剪切的mRNA疫苗可有效表达多种病毒结构蛋白，并且可以激发强有力的免疫反应，保护哺乳仔猪免受PDCoV感染
Ruiming Yu,Yingjie Bai,Liping Zhang et al.
Ruiming Yu et al.
As an emerging swine enteric coronavirus, porcine deltacoronavirus (PDCoV) poses a severe threat to the global swine industry and has demonstrated potential for cross-species transmission. Therefore, the development of safe and effective va...
Zika virus infection in neonatal mice disrupts connexin 43 and induces cardiac inflammation, implicating viral myocarditis in neonatal pathogenesis [0.03%]
新生儿小鼠寨胺病毒（ZIKV）感染导致缝隙连接蛋白43异常及心脏炎症，提示病毒感染与病毒性心肌炎相关联
Shuxuan Li,Wangheng Hou,Najealicka Armstrong et al.
Shuxuan Li et al.
Zika virus (ZIKV) is primarily transmitted through mosquito bites and, occasionally, via breast milk, making postnatal ZIKV infections common among newborns and infants, particularly in tropical regions. Previous studies, including ours, ha...
The 5'-end segment-specific noncoding region of influenza A virus regulates both competitive multi-segment RNA transcription and selective genome packaging during infection [0.03%]
流感A病毒的5'-端段特异性非编码区在感染期间调控竞争性多片段转录及选择性基因组包装
Zining Liu,Lei Zhang,Wenyu Zhang et al.
Zining Liu et al.
The 3' and 5' termini of the eight RNA segments of the influenza A virus (IAV) genome contain segment-specific or subtype-specific (in HA and NA segments) noncoding regions (ssNCRs), located between the highly conserved terminal promoter se...
T-cell receptor/CD28-targeted immunotherapeutics selectively drive naive T-cell expansion to generate functional HIV-specific responses [0.03%]
针对T细胞受体/CD28的免疫治疗选择性地驱动初始T细胞增殖以生成功能性的HIV特异性反应
April L Mueller,Sara Lamcaj,Scott Garforth et al.
April L Mueller et al.
Adoptive cell transfer (ACT), a promising immunotherapeutic approach, treats viral infections or cancer by ex vivo expansion and infusion of antigen-specific CD8+ T cells, respectively. However, its wider use is limited by logistical challe...
Biographical Feature: Diane E. Griffin and Ann Palmenberg-luminaries in RNA virology [0.03%]
人物访谈——Diane E. Griffin和Ann Palmenberg：RNA病毒学的杰出学者
Robert F Kalejta,Paul D Friesen,Andrew Pekosz et al.
Robert F Kalejta et al.
Trained ILCs confer adaptive immunity-independent protection against influenza [0.03%]
训练过的ILC提供抗流感的适应性免疫非依赖性的保护作用
Wadzanai P Mboko,Yuanyuan Wang,Weiping Cao et al.
Wadzanai P Mboko et al.
Seasonal influenza causes 290,000-650,000 deaths annually, with vaccination efficacy ranging from 10 to 60%. The emergence of drug-resistant and highly pathogenic avian influenza viruses underscores the urgent need for novel protective stra...
Modeling of hepatitis B virus infection spread in primary human hepatocytes [0.03%]
用原代人类肝细胞模型模拟乙型肝炎病毒感染的传播
Zhenzhen Shi,Masataka Tsuge,Nicholson Collier et al.
Zhenzhen Shi et al.
Chronic hepatitis B virus (HBV) infection poses a significant global health threat, causing severe liver diseases including cirrhosis and hepatocellular carcinoma. We characterized HBV DNA kinetics in primary human hepatocytes (PHHs) over 3...
Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine [0.03%]
猪肺巨噬细胞中Nsp2复制酶介导的PRRSV-2活疫苗病毒去被膜作用导致其毒力减弱
Yuan-Zhe Bai,Hu Xu,Yong-Gang Liu et al.
Yuan-Zhe Bai et al.
Type 2 porcine reproductive and respiratory syndrome virus (PRRSV-2) poses a major threat to global swine production. While live attenuated vaccines (LAVs) remain the most effective countermeasure, the molecular mechanisms underlying PRRSV-...
Louis Flamand,Jesse Arbuckle,Pascale Bonnafous et al.
Louis Flamand et al.
Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA-now proposed to be called "endogenous HHV-6A/B (eHHV-6A/B)." Present in 0.2-3% of humans, this integrated DNA is passed to offspring ...