Evaluation of long-term immunity following inoculation with highly diverse orthomarburgvirus isolates in Egyptian rousette bats (Rousettus aegyptiacus) [0.03%]
评估埃及鼠耳蝠（Rousettus aegyptiacus）接种高度多样的正玛堡病毒株后的长期免疫力
Jessica A Elbert,Amy J Schuh,Brian R Amman et al.
Jessica A Elbert et al.
Viral coinfections and their impact on long-term immunity represent an understudied area in disease ecology and infectious disease research. Coinfections can influence the host's susceptibility to future infections, alter host and pathogen ...
Yining Wang,Xin Wang,Tunca Doğan et al.
Yining Wang et al.
Mpox, caused by monkeypox virus (MPXV) infection, has emerged as a significant global health threat. The World Health Organization (WHO) has twice declared a Public Health Emergency of International Concern for mpox: first for the 2022-2023...
Expression of spike and hemagglutinin-esterase proteins is necessary to recover infectious recombinant bovine coronavirus [0.03%]
Spike和血凝素-酯酶蛋白的表达对恢复重组牛冠状病毒是必需的
Yoshiro Sugiura,Tatsuki Takahashi,Shiori Ueno et al.
Yoshiro Sugiura et al.
Bovine coronavirus (BCoV) is a significant pathogen in cattle, and its virological analysis has been hampered by the difficulty in isolating and culturing field isolates with high titers. Here, we successfully generated recombinant BCoV usi...
Cathepsin L and transmembrane serine protease 11E mediate trypsin-independent entry of porcine deltacoronavirus into Huh7 cells [0.03%]
溶细胞蛋白酶L和跨膜丝氨酸蛋白酶11E介导猪Delta冠状病毒对Huh7细胞的不依赖胰蛋白酶入侵作用
Wenwen Xiao,Yuanxiang Xiong,Yuchen Wang et al.
Wenwen Xiao et al.
Porcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus with zoonotic potential. Previous studies showed that PDCoV productive infection is dependent on exogenous trypsin in porcine-derived cells. In this study, we found that tr...
LEF-6 phosphorylation regulates the binding and trafficking of baculovirus late gene transcripts [0.03%]
LEF-6的磷酸化调控杆状病毒晚期基因转录本的结合和转运
Xiaoyue Zhang,Zhihui Zhang,Ziqian Cao et al.
Xiaoyue Zhang et al.
The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) LEF-6 has been shown to accelerate the infection cycle of AcMNPV, but its specific function is yet to be defined. In the present study, we identify LEF-6 as an RNA-binding pr...
SARS-CoV-2 causes chronic lung inflammation and impaired respiratory capacity in aged Roborovski dwarf hamsters [0.03%]
SARS-CoV-2导致罗布罗夫斯基侏儒仓鼠慢性肺部炎症和呼吸能力受损
Amirhossein Karimi,Carolin M Lieber,Kaori Sakamoto et al.
Amirhossein Karimi et al.
Roborovski dwarf hamsters are permissive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and progress to acute viral pneumonia with profound lung tissue injury, recapitulating hallmarks of severe coronavirus disea...
Inflammatory, transcriptomic, and cell fate responses underlying the mammalian transmission of avian influenza viruses [0.03%]
禽流感病毒在哺乳动物中的传播机制：炎症、转录组和细胞命运的响应研究
Mark Zanin,Timothy Flerlage,Sook-San Wong et al.
Mark Zanin et al.
Airborne transmissibility of avian influenza viruses (AIVs) in humans is considered an essential component of their pandemic risk. Although several viral factors regulating airborne transmission (AT) have been delineated, it is not known wh...
A versatile H5N1-VSV platform for safe influenza virus research applications [0.03%]
一种用于安全进行流感病毒研究的H5N1-VSV多功能平台
Boopathi Sownthirarajan,Maya Mason,Gayathri Loganathan et al.
Boopathi Sownthirarajan et al.
The H5N1 strain of influenza A virus (IAV) continues to cause severe infections in a range of avian and mammalian species, including sporadic but concerning cases in humans. There is growing concern that circulating H5N1 strains could lead ...
A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants [0.03%]
一种发光的冠状病毒SARS-CoV-2弱毒株用于识别和验证抗药性突变体
Yao Ma,Chengjin Ye,Ahmed Magdy Khalil et al.
Yao Ma et al.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has necessitated a continuous updating of vaccines. In contrast, antivirals remained effective as they target conserved viral proteins that are essential...
Visualization and tracking of tubule-derived, fluorescent-labeled NS1 as a marker of bluetongue virus in living cells [0.03%]
活细胞中可视化并追踪荧光标记的NS1(作为蓝舌病病毒标志物)沿小管运输的现象
Yuqing Song,Xuechun Liu,Yongjun Che et al.
Yuqing Song et al.
Bluetongue virus (BTV) is an arbovirus (genus, Orbivirus; family, Sedoreoviridae) transmitted among ruminant hosts by Culicoides biting midges (genus, Culicoides). Orbivirus sp. produce large numbers of virus-specific tubules during infecti...