N-linked glycans on the stalk of influenza virus neuraminidase promote functional tetramer formation by compensating for local hydrophobicity [0.03%]
N连接糖基对流感病毒神经氨酸酶茎部促进功能性四聚体形成以补偿局部疏水性
Soma Saeidi,Hongquan Wan,Hyeog Kang et al.
Soma Saeidi et al.
Enveloped virus surface antigens, such as influenza neuraminidase (NA), typically depend on N-linked glycans for assembly, trafficking in the host cell, and immune evasion. Here, we examined the function of the N-linked glycans on the NA st...
Pseudomonas aeruginosa rhamnolipids stabilize human rhinovirus 14 virions [0.03%]
芽孢杆菌噬菌体14病毒粒子的假单胞菌脂肪酸代谢产物鼠李糖脂稳定化
Joshua J Baty,Aidan K Drozdick,Julie K Pfeiffer
Joshua J Baty
Many mammalian viruses encounter bacteria and bacterial molecules over the course of infection. Previous work has shown that the microbial ecology of the gut plays an integral role in poliovirus and coxsackievirus infection, where bacterial...
Discovery and rescue of porcine bastroviruses associated with polioencephalomyelitis in domestic pigs [0.03%]
与家猪多发性脑脊髓炎相关的猪胎盘病毒的发现和营救
Nicole Wildi,Stefano Bagatella,Xuanxuan Zhang et al.
Nicole Wildi et al.
Bastroviruses (BastV) are non-enveloped single-stranded positive-sense RNA viruses that have been discovered recently in feces samples of different animals and humans. The non-structural proteins of these viruses show similarities to those ...
Envelope-dimer epitope 1 (EDE1) antibody (C10) treatment significantly reduces Zika virus replication in the male and female reproductive tracts [0.03%]
抗包膜二聚体表位1(EDE1)(C10)抗体显著降低寨卡病毒在男女生殖道中的复制能力
Nathaniel J Schramm,Martina Kovarova,Shajer Manzoor et al.
Nathaniel J Schramm et al.
No effective therapy or vaccine exists to protect against the next Zika virus (ZIKV) outbreak. ZIKV has been detected in multiple organs of infected people, including immune-privileged sites like the brain, eyes, and reproductive tract. ZIK...
GP2a I118 and GP4 D43 play critical roles in the attachment of PRRSV to the CD163 receptor: implications for anti-PRRSV infection targets [0.03%]
GP2a I118 和 GP4 D43 在猪繁殖与呼吸综合征病毒附着至CD163受体过程中起关键作用：针对抗猪瘟病毒感染靶点的启示
Guoqing Liu,Xinyi Huang,Yongbo Yang et al.
Guoqing Liu et al.
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant threat to the global swine industry. Numerous modified live vaccines (MLVs) against PRRSV have been developed through the serial passage of wild-type parental s...
An African swine fever virus-specific antibody reactome reveals antigens as potential candidates for vaccine development [0.03%]
非洲猪瘟病毒特异性抗体抗原组的鉴定揭示了疫苗开发的潜在候选抗原
Songxin Guo,Yi Ru,Hui Zhang et al.
Songxin Guo et al.
Developing an efficient and safe vaccine for African swine fever (ASF), a devastating disease of pigs, remains a significant challenge mainly due to limited knowledge of the immune correlates of protection. Identifying protective determinan...
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection [0.03%]
自组装花色苷-3-O-葡萄糖苷纳米颗粒可缓解PRRSV感染诱导的炎症及铁死亡
Xiaohan Chen,Yipeng Pang,Fructueux Modeste Amona et al.
Xiaohan Chen et al.
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious pathogen that causes substantial economic losses in the global swine industry, primarily by impairing reproductive performance and respiratory health. Howeve...
Assessing the structural boundaries of broadly reactive antibody interactions with diverse H3 influenza hemagglutinin proteins [0.03%]
评估广谱反应性抗体与多様H3流感血凝素蛋白相互作用的结构界限
John V Dzimianski,Kaito A Nagashima,Joseph M Cruz et al.
John V Dzimianski et al.
Influenza virus infections are an ongoing seasonal disease burden and a persistent pandemic threat. Formulating successful vaccines remains a challenge due to accumulating mutations in circulating strains, necessitating the development of i...
Bethany A O&#x;Hara,Kaitlin Garabian,Wenqing Yuan et al.
Bethany A O&#x;Hara et al.
Progressive multifocal leukoencephalopathy (PML), an often-fatal neurodegenerative disease, is caused by the neuroinvasive polyomavirus JCPyV. Peripheral organs, including the kidney, are the site of lifelong persistent infections that are ...
Proliferative proteome induced by HPV 16E6 and NFX1-123 partnership in longitudinal keratinocyte cultures [0.03%]
人乳头状瘤病毒16型E6和NFX1-123合作者诱导的纵向角质形成细胞培养增殖蛋白组分分析
C L Billingsley,E H Doud,W Smith-Kinnaman et al.
C L Billingsley et al.
Human papillomaviruses (HPVs) cause cervical, anogenital, and oropharyngeal cancers. Despite the availability of preventive HPV vaccines, their poor uptake leaves individuals at risk for these cancers, many of which remain common globally a...