Human cytomegalovirus promotes de novo PC synthesis during early virus replication [0.03%]
人巨细胞病毒在病毒感染早期促进从头合成磷脂酰胆碱
Ian Kline,Rebekah L Mokry,Yuecheng Xi et al.
Ian Kline et al.
Human cytomegalovirus (HCMV) infection reprograms metabolism, including lipid synthesis. While several metabolite-related pathways exhibit altered activity in infected cells, the alteration of lipid-related pathways by HCMV has not been exa...
Influence of the pre-membrane and envelope proteins on structure, pathogenicity, and tropism of tick-borne encephalitis virus [0.03%]
前期膜蛋白和包膜蛋白对蜱传脑炎病毒结构、致病性和嗜神经性的影响
Ebba Rosendal,Kyrylo Bisikalo,Stefanie M A Willekens et al.
Ebba Rosendal et al.
Tick-borne encephalitis virus (TBEV) is a neurotropic flavivirus that causes thousands of human infections annually. Viral tropism in the brain is determined by the presence of necessary receptors, entry factors, and the ability of the viru...
ESCRT-III is recruited by human herpesvirus 6A nuclear egress complex to promote nuclear egress of the nucleocapsid [0.03%]
人类疱疹病毒6A核出芽复合体招募ESCRT-III以促进衣壳的核出芽
Aila Gulijiahani,Jun Arii,Vuk Isakovic et al.
Aila Gulijiahani et al.
Herpesviruses replicate their genomes and package them into capsids within the host cell nucleus. These capsids must then translocate from the nucleus to the cytoplasm through a process designated nuclear egress. The virus-encoded nuclear e...
Elevated peripheral and nervous system inflammation is associated with decreased short-chain fatty acid levels in Zika virus-infected macaques [0.03%]
寨卡病毒感染猕猴外周和神经系统炎症升高与短链脂肪酸水平降低相关
Ty A Schroeder,Jennifer A Manuzak,Charlene J Miller et al.
Ty A Schroeder et al.
Zika virus (ZIKV) infection typically results in mild symptoms; however, it can cause elevated inflammation in the CNS and the development of more serious conditions, including severe neurological syndromes. Previous studies have demonstrat...
Mucosal vaccination with long-form TSLP induces migratory cDC1-mediated adaptive immunity against SARS-CoV-2 infection [0.03%]
长形式TSLP粘膜免疫诱导迁移cDC1介导的适应性免疫反应对抗SARS-CoV-2感染
Jing Hu,Housheng Zheng,Wei Ran et al.
Jing Hu et al.
A combination of vaccination strategies will potentially be required for effective control of the virus pandemic. We report that mice intranasally immunized with commercial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subuni...
The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions [0.03%]
单纯疱疹病毒-1产生细胞的类型改变病毒体蛋白质组含量及感染能力
Gary Dunn,Luke F Domanico,Matthew P Taylor
Gary Dunn
The cell that a virus replicates in, that is, the producer cell, can alter the macromolecular composition and infectious capacity of the virions that are produced. Herpes simplex virus type 1 (HSV-1) primarily infects keratinocytes of the e...
Interaction of West Nile virus NS5 with orthoflavivirus SLA RNAs and their effects on viral replication and inhibition [0.03%]
西尼罗病毒NS5与正黄病毒SLA RNA的相互作用及其对病毒复制和抑制的影响
Mandi A Feinberg,My T Le,Kassandra L Carpio et al.
Mandi A Feinberg et al.
West Nile virus (WNV) is a single-stranded, positive-sense RNA virus in the Orthoflavivirus genus, within Flaviviridae. The genus encompasses numerous pathogens of public health importance, including WNV, dengue virus (DENV), Zika virus (ZI...
Structural dissection of vaccinia G9 identifies residues essential for membrane fusion and complex assembly [0.03%]
结构解析痘病毒G9蛋白鉴定出膜融合和复合物组装所需的关键氨基酸残基
Hsiao-Jung Chiu,Hao-Ching Wang,Wen Chang
Hsiao-Jung Chiu
Vaccinia virus, a prototypical poxvirus, utilizes a unique multi-protein entry fusion complex (EFC), comprising 11 components, to mediate membrane fusion during host cell entry. Although the crystal structure of a truncated form of the G9 p...
ARRDC1 inhibits the replication of Semliki Forest virus by regulating the ubiquitination and degradation of viral nsP4 [0.03%]
ARRDC1通过调节病毒nsP4的泛素化降解抑制塞姆利基森林病毒复制
Qinyu Peng,Xiaoyi Yang,Cancan Chen et al.
Qinyu Peng et al.
Alphavirus infection can result in a spectrum of clinical manifestations in the host, including fever, rash, arthritis, and even symptoms of encephalitis, thereby posing a severe threat to global public health security. In this study, we ex...
Ubiquitin-specific protease 15 interacts directly with the HSV-1 alkaline nuclease and facilitates viral recombination and replication fork stability [0.03%]
泛素特异性蛋白酶15与HSV-1碱性内切酶直接相互作用并促进病毒重组及复制叉稳定
Yee Vue,Patrick J Mullon,Alexander Leehangin et al.
Yee Vue et al.
Herpes simplex virus type 1 replicates in the nucleus of the host cell and utilizes many cellular proteins to facilitate DNA replication. HSV-1 DNA replication is closely linked with homologous recombination, and HSV-1 encodes a two-subunit...