Harnessing the power of IFN for therapeutic approaches to COVID-19 [0.03%]
利用IFN的力量进行COVID-19治疗手段的研究
Elise G Viox,Steven E Bosinger,Daniel C Douek et al.
Elise G Viox et al.
Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19,...
Murine norovirus mutants adapted to replicate in human cells reveal a post-entry restriction [0.03%]
适应在人类细胞中复制的鼠诺如病毒突变体揭示了一种限制病毒感染的机制
Melissa R Budicini,Valerie J Rodriguez-Irizarry,Robert W Maples et al.
Melissa R Budicini et al.
RNA viruses lack proofreading in their RNA polymerases and therefore exist as genetically diverse populations. By exposing these diverse viral populations to selective pressures, viruses with mutations that confer fitness advantages can be ...
The TRAF3-DYRK1A-RAD54L2 complex maintains ACE2 expression to promote SARS-CoV-2 infection [0.03%]
TRAF3-DYRK1A-RAD54L2复合体维持ACE2表达以促进SARS-CoV-2感染
Dexin Mao,Shufeng Liu,An Thanh Phan et al.
Dexin Mao et al.
Angiotensin converting enzyme 2 (ACE2), the host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is differentially expressed in a wide variety of tissues and cell types. The expression of ACE2 is under t...
A tetravalent dengue virus-like particle vaccine induces high levels of neutralizing antibodies and reduces dengue replication in non-human primates [0.03%]
四价登革病毒样粒子疫苗诱导高水平的中和抗体并降低非人灵长类动物中的登革热复制
Daniel Thoresen,Kenta Matsuda,Akane Urakami et al.
Daniel Thoresen et al.
Dengue virus (DENV) represents a significant global health burden, with 50% of the world's population at risk of infection, and there is an urgent need for next-generation vaccines. Virus-like particle (VLP)-based vaccines, which mimic the ...
Second Correction for Shin et al., "Histone Deacetylase Classes I and II Regulate Kaposi's Sarcoma-Associated Herpesvirus Reactivation" [0.03%]
申等人的第二校正："组蛋白去乙酰酶I类和II类调节卡波西肉瘤疱疹病毒再活化"
Hye Jin Shin,Jennifer DeCotiis,Mario Giron et al.
Hye Jin Shin et al.
Published Erratum
Journal of virology. 2024 May 14;98(5):e0038624. DOI:10.1128/jvi.00386-24 2024
Identification of a membrane-associated element (MAE) in the C-terminal region of SARS-CoV-2 nsp6 that is essential for viral replication [0.03%]
SARS-CoV-2 nsp6 C端区段存在一个对病毒复制必不可少的膜相关元件（MAE）
Yuying Han,Zhenghong Yuan,Zhigang Yi
Yuying Han
The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has rapidly spread worldwide since its emergence in late 2019. Its ongoing evolution poses ...
Expanding the adenovirus toolbox: reporter viruses for studying the dynamics of human adenovirus replication [0.03%]
扩展腺病毒工具箱：研究人类腺病毒复制动态的报告病毒
Cason R King,Mackenzie J Dodge,Katelyn M MacNeil et al.
Cason R King et al.
To streamline standard virological assays, we developed a suite of nine fluorescent or bioluminescent replication competent human species C5 adenovirus reporter viruses that mimic their parental wild-type counterpart. These reporter viruses...
Pseudorabies virus usurps non-muscle myosin heavy chain IIA to dampen viral DNA recognition by cGAS for antagonism of host antiviral innate immunity [0.03%]
伪狂犬病毒劫持非肌球蛋白重链IIA以抑制cGAS识别病毒DNA并拮抗宿主抗病毒先天免疫响应
Yingqi Liu,Yidan Qin,Bingbing Yang et al.
Yingqi Liu et al.
Alphaherpesvirus pseudorabies virus (PRV) causes severe economic losses to the global pig industry and has garnered increasing attention due to its broad host range including humans. PRV has developed a variety of strategies to antagonize h...
OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway [0.03%]
OASL通过自噬途径降解VP2抑制传染性法氏囊病病毒复制
Suyan Wang,Zhuangzhuang Xu,Yongzhen Liu et al.
Suyan Wang et al.
Infectious bursal disease (IBD) is an acute and fatal immunosuppressive disease caused by infectious bursal disease virus (IBDV). As an obligate intracellular parasite, IBDV infection is strictly regulated by host factors. Knowledge on the ...
Sialic acids as attachment factors in mosquitoes mediating Japanese encephalitis virus infection [0.03%]
唾液酸作为蚊媒脑炎病毒的感染介体附件因素
Yi He,Chang Miao,Shiping Yang et al.
Yi He et al.
The role of Culex mosquitoes in the transmission of Japanese encephalitis virus (JEV) is crucial, yet the mechanisms of JEV infection in these vectors remain unclear. Previous research has indicated that various host factors participate in ...