Giant endogenous viral elements in the genome of the model protist Euglena gracilis reveal past interactions with giant viruses [0.03%]
在模式原生生物Euglena gracilis基因组中的巨大内源病毒元件揭示了其与巨病毒感染的相互作用
Abdeali M Jivaji,Sangita Karki,Emma Franken et al.
Abdeali M Jivaji et al.
Genomes of giant viruses (phylum Nucleocytoviricota) have increasingly been found integrated into the genomes of diverse eukaryotes. Here, we report eight giant endogenous viral elements (GEVEs) in the genome of the microalgae Euglena graci...
Nanoparticle vaccine based on the pre-fusion F glycoprotein of respiratory syncytial virus elicits robust protective immune responses [0.03%]
基于呼吸道合胞病毒融合前F糖蛋白的纳米颗粒疫苗诱导强大的保护性免疫反应
Zhulong Hu,Siyu Tian,Yu Zhou et al.
Zhulong Hu et al.
Respiratory syncytial virus (RSV) is a global public health concern. Currently, RSV vaccines are approved only for use in older adults, while preventing the disease in infants and children, as well as ensuring vaccine durability, remains a ...
SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase [0.03%]
AXL/GAS6通过AXL激酶激活的PI3K-PLC依赖性巨胞饮作用介导SFTSV进入细胞
Zecheng Jin,Shuhei Taguwa,Junki Hirano et al.
Zecheng Jin et al.
Severe fever with thrombocytopenia syndrome (SFTS) is a significant public health concern caused by SFTS virus (SFTSV), a tick-borne RNA virus. Previous studies have identified DC-SIGN and related C-type lectins as receptors of SFTSV infect...
Dairy cattle herds mount a characteristic antibody response to highly pathogenic H5N1 avian influenza viruses [0.03%]
dairy cattle对高致病性H5N1禽流感病毒产生特征性的抗体反应
Lindsey R Robinson-McCarthy,Holly C Simmons,Aaron L Graber et al.
Lindsey R Robinson-McCarthy et al.
An unprecedented outbreak of a highly pathogenic avian influenza virus, H5 clade 2.3.4.4b, was reported in U.S. dairy cattle during the spring of 2024. It has now spread to hundreds of herds across multiple states. In humans, antibodies to ...
Permissiveness of different TMEM154 genotype cell lines to different SRLV genotypes/subtypes [0.03%]
不同TMEM154基因型细胞系对不同SRLV基因型/亚型的易感性分析
Barbara Colitti,Daniele Avanzato,Riccardo Moretti et al.
Barbara Colitti et al.
Small ruminant lentiviruses (SRLVs) are a heterogeneous group of viruses that infect goats and sheep worldwide, for which no cures or effective vaccines are available. Control measures have been based on early diagnosis and accurate managem...
Jonathon C O Mifsud,Marc A Suchard,Edward C Holmes et al.
Jonathon C O Mifsud et al.
The rapid rate of virus evolution, while useful for outbreak investigations, poses a challenge for accurately estimating long-term viral evolutionary divergence and leaves us with little genomic traces at deep evolutionary timescales, compl...
A novel nanoparticle vaccine, based on S1-CTD, elicits robust protective immune responses against porcine deltacoronavirus [0.03%]
一种基于S1-CTD的新型纳米颗粒疫苗可诱导对猪德尔塔冠状病毒的强力保护性免疫反应
Qing He,Yawen Zou,Beilei Yu et al.
Qing He et al.
Porcine deltacoronavirus (PDCoV), an emerging swine pathogen causing severe enteric disease in piglets, poses cross-species transmission risks, including humans. The C-terminal domain (CTD) of its spike protein harbors a key receptor-bindin...
Parallel evolution of the elite neutralizer phenotype in divergent HIV-1 clades [0.03%]
不同HIV-1亚型中精英体液免疫应答的平行进化规律
Kathryn A Mesa,Sophia W Li,Jennie M Hutchinson et al.
Kathryn A Mesa et al.
The development of an effective vaccine against HIV-1 requires understanding how broadly neutralizing antibodies (bNAbs) evolve in natural viral infections. Here, we recovered 152 envelope sequences from two elite neutralizers (ENs) and fiv...
Coatomer protein complex I is required for efficient secretion of dengue virus non-structural protein 1 [0.03%]
网格蛋白包被小泡I复合体是登革病毒非结构蛋白1高效分泌的必要条件
Stephen M Johnson,Siena M Centofanti,Gustavo Bracho et al.
Stephen M Johnson et al.
Secreted non-structural protein 1 (sNS1) is an important orthoflavivirus pathogenic factor that can induce vascular leakage, a key symptom of severe dengue disease. Given the role of sNS1 in dengue pathogenesis, defining the molecular mecha...
Identification of Epstein-Barr virus BORF2 sequences required for APOBEC3B relocalization [0.03%]
识别EB病毒BORF2序列以实现APOBEC3B重定位
Farren Clark,Michael A Carpenter,Reuben S Harris et al.
Farren Clark et al.
Epstein-Barr virus (EBV) is a common herpesvirus that establishes lifetime infections in most people worldwide. To protect the lytically replicating EBV genomes from mutation, the EBV BORF2 protein relocalizes the APOBEC3B cytosine deaminas...