Intracellular iron positively modulates the replicative cycle of mimiviruses, increasing virus production [0.03%]
Juliana Dos Santos Oliveira,Claudia F Dick,Gabriel Henrique Pereira Nunes et al.
Juliana Dos Santos Oliveira et al.
Mimiviruses, members of the Nucleocytoviricota phylum, produce large, pseudo-icosahedral virions densely coated with fibrils, except at a specialized fivefold vertex known as the stargate. Stargate opening is essential for delivering the vi...
The E3 ubiquitin ligase STUB1 inhibits Senecavirus A replication by mediating VP1 ubiquitination and proteasomal degradation [0.03%]
Penghui Zeng,Jingyu Mao,Jinshuo Guo et al.
Penghui Zeng et al.
Senecavirus A (SVA), an emerging vesicular pathogen, poses a significant threat to the global pig industry. STIP1 homology and U-box-containing protein 1 (STUB1), a chaperone-dependent E3 ubiquitin ligase, plays a pivotal role in protein qu...
Primary envelopment of Kaposi's sarcoma-associated herpesvirus at the nucleoplasmic reticulum [0.03%]
卡波西肉瘤疱疹病毒在核网状结构中的初级包裹过程
Alexa Wilson,Neale D Ridgway,Craig McCormick
Alexa Wilson
Herpesvirus egress begins with primary envelopment of newly assembled capsids at the inner nuclear membrane (INM). Primary envelopment has been observed at the peripheral INM as well as nuclear infoldings. Nuclear infoldings from invaginati...
Correction for Zhao et al., "IDO1 promotes CSFV replication by mediating tryptophan metabolism to inhibit NF-κB signaling" [0.03%]
对 Zhao 等人题为“IDO1 通过介导色氨酸代谢抑制 NF-κB 信号转导促进 Classical Swine Fever Virus 复制”的更正
Feifan Zhao,Yaoyao Huang,Junzhi Ji et al.
Feifan Zhao et al.
Published Erratum
Journal of virology. 2025 Sep 30:e0109425. DOI:10.1128/jvi.01094-25 2025
HIV proviral transcription and infectivity are enhanced by neddylation [0.03%]
Neddylation促进人类免疫缺陷病毒的转录和感染能力
Cristina C Vaca,Hannah Hudson,Isabelle Clerc et al.
Cristina C Vaca et al.
A spreading infection can quickly restart from the persistent reservoir of cells harboring HIV proviruses if antiretroviral therapy (ART) is stopped. HIV transcription can also be increased by latency-reversing agents (LRAs) during ART. Ned...
Naoto Koyanagi,Kosuke Takeshima,Saori Shio et al.
Naoto Koyanagi et al.
Although previous studies reported that the herpes simplex virus 2 (HSV-2) UL13 protein kinase mediates the phosphorylation of elongation factor 1δ (EF-1δ) in infected cells, we found here that individual expression of UL13 was insufficie...
Epigenetic motifs distinguishing endogenous from exogenous retroviral integrants [0.03%]
表征内源性逆转录病毒和外源性逆转录病毒插入位点的表观遗传模式
Sarah LaMere,Hanbei Xiong,Wei Wang et al.
Sarah LaMere et al.
Retroviruses are subject to epigenetic regulation by the host genome after integrating, similar to vertebrate genes. However, their patterns of integration, and therefore their likely epigenetic regulation, differ between genera. Beta- and ...
Developing an eVLP mRNA vaccine for respiratory syncytial virus with enhanced pre-fusion targeting humoral responses [0.03%]
一种针对呼吸道合胞病毒的eVLP mRNA疫苗，具有增强的以前融合状态为目标的体液免疫反应
Lei Sun,Mengting Huang,Simin Feng et al.
Lei Sun et al.
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease (LRTD) in infants, the elderly, and immunocompromised individuals. In this study, we leveraged the innovative EABR (ESCRT- and ALIX-binding region) vacc...
Pseudorabies virus DNA polymerase processivity factor pUL42 inhibits type I IFN production by negatively regulating cGAS-STING signaling pathway [0.03%]
伪狂犬病毒DNA聚合酶进程性因子pUL42通过负向调控cGAS-STING信号通路抑制I型干扰素产生
Guangqiang Ye,Jiaxiu Gao,Haoxuan Cao et al.
Guangqiang Ye et al.
Pseudorabies (PR), caused by the PR virus (PRV), is an acute infectious disease in livestock and various wild animals. PRV has developed several immune evasion mechanisms to antagonize the host's antiviral immune response. However, the prec...
Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling [0.03%]
识别黄病毒科登梅苏病毒NS5蛋白新型干扰素拮抗区簇
Ji Zhang,Yunhao Fan,Da An et al.
Ji Zhang et al.
Numerous species in the genus Flavivirus have been identified to pose serious threats to public health. Most of them have developed evasion strategies to counteract antiviral activity triggered by type I interferon (IFN-I), making preventio...