Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL-KrasG12D /+; p48Cre/+ Mice [0.03%]
苦瓜汁对LSL-KrasG12D /+；p48Cre /+小鼠胰腺癌变的化学预防作用
Lakshmi Sai Pratyusha Bugata,Deepanshi Dhar,Rama Kant et al.
Lakshmi Sai Pratyusha Bugata et al.
Herein, using the LSL-KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC...
ATP13A2 Promotes Endothelial Angiogenic Phenotypes and Is Associated With Poor Prognosis in Liver Hepatocellular Carcinoma [0.03%]
ATP13A2促进内皮细胞的血管生成表型并与肝 hepatocellular carcinoma不良预后相关
Qi Liu,Yuyang Liu,Junyi Chen et al.
Qi Liu et al.
Liver hepatocellular carcinoma (LIHC) is a molecularly heterogeneous malignancy for which additional genetically supported biomarkers and functional regulators remain to be identified. We aimed to identify candidate genes through integrativ...
ATP13A2 Promotes Endothelial Angiogenic Phenotypes and Is Associated With Poor Prognosis in Liver Hepatocellular Carcinoma [0.03%]
ATP13A2促进内皮细胞的血管生成表型并与肝细胞肝癌预后不良相关
Qi Liu,Yuyang Liu,Junyi Chen et al.
Qi Liu et al.
Liver hepatocellular carcinoma (LIHC) is a molecularly heterogeneous malignancy for which additional genetically supported biomarkers and functional regulators remain to be identified. We aimed to identify candidate genes through integrativ...
DUSP9 Regulates Hepatoblastoma Progression With Implications for Diagnosis and Targeted Therapy [0.03%]
DUSP9调节肝母细胞瘤的发生发展并对其诊断和靶向治疗具有重要影响
Pingping Zhou,Xiongwei Wu,Qvanxin Yang et al.
Pingping Zhou et al.
This study investigated the mechanistic role of DUSP9 in hepatoblastoma (HB) development and progression to provide new insights into the diagnosis and treatment of pediatric HB. Pediatric HB mRNA expression data were obtained from the GEO ...
4H-CRCXL Mitigates RasV12-Induced Phenotypes in Glioblastoma Model of Drosophila [0.03%]
4H-CRCXL缓解果蝇胶质母细胞瘤模型中RasV12诱导的表型
Pradeep Kumar,Vaishali Raghuvanshi,Prabhat Kumar et al.
Pradeep Kumar et al.
Glioblastoma (GBM), a Grade IV malignant brain tumor, accounts for over half of all gliomas and remains resistant to current therapies, requiring the development of novel treatment strategies. Aberrant Ras signaling and PI3K/Akt hyperactiva...
Integrated Immunological Analysis of Interactions Between CXCL13+ T Cells and LAMP3+ DC in the Immunotherapy Response of Bladder Cancer [0.03%]
膀胱癌免疫治疗反应中CXCL13+T细胞和LAMP3+DC相互作用的综合免疫学分析
Lin Zhou,Jinchao Zhu,Yushan Liu et al.
Lin Zhou et al.
CXCL13+ T cells and LAMP3+ dendritic cells (DCs) are pivotal players in orchestrating anti-tumor immune responses, particularly within tumor tertiary lymphoid structures (TLS). However, their heterogeneity, differentiation trajectories, and...
Neferine-Targeted Inhibition of TrxR1 Triggers Apoptosis Through Disrupting Redox Homeostasis in Pancreatic Cancer Cells [0.03%]
靶向抑制TrxR1触发红系细胞凋零通过扰乱胰腺癌细胞的氧化还原平衡
Xiaoqing Yuan,Si Jiang,Guanqing Zhang et al.
Xiaoqing Yuan et al.
Overactivation of thioredoxin reductase 1 (TrxR1) is implicated in tumor development. This study aims to elucidate the efficacy and mechanisms by which neferine (Nef) exerts its anti-tumor effects in pancreatic cancer through targeting TrxR...
Breast Cancer-Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4-Dependent Extracellular Trap Formation [0.03%]
乳腺来源的AZU1通过PAD4依赖性细胞外诱捕网形成教育中性粒细胞促进肿瘤进程和转移
Zhen Huang,Zhe Wu,Guiyue Zhu et al.
Zhen Huang et al.
Neutrophil extracellular traps (NETs) play crucial roles in cancer progression, but their regulatory mechanisms in breast cancer remain poorly understood. We developed a NETs-related prognostic risk model using TCGA breast cancer data and i...
Cancer-Associated Fibroblast-Derived FGF7 Promotes Immune Escape in Oral Squamous Cell Carcinoma via JAK/STAT3-Mediated PD-L1 Expression [0.03%]
癌相关成纤维细胞衍生的FGF7通过JAK/STAT3介导的PD-L1表达促进口腔鳞状细胞癌免疫逃逸
Qinghua Liu,Dongbin Chen,Juncai Lin et al.
Qinghua Liu et al.
Oral squamous cell carcinoma (OSCC) exhibits high recurrence rates, and immune escape within the tumor microenvironment is a critical barrier to effective therapy. This study investigates whether cancer-associated fibroblast (CAF)-derived F...
Epitranscriptomic Regulation of ALDOA by SHMT2-Mediated m6A Modification Drives Gastric Cancer Malignancy [0.03%]
甘氨酸脱氨酶介导的m5C修饰调控GALE在肝癌中的作用机制研究
Peng Li,Chengyun Niu,Dongni Zhao et al.
Peng Li et al.
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic advancements despite progress in early detection. Serine hydroxymethyltransferase 2 (SHMT2), a key metabolic enzyme, and fructose-1,...