Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma [0.03%]
髓系FAK促进肝细胞癌中的巨噬细胞积累但不影响肿瘤进展
Eugene Ham,Kyle Boedeker,Claudia Rose Keating et al.
Eugene Ham et al.
Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune-based treatment strategies such as atezolizumab plus bevacizumab have shown promis...
Effects of Isorhapontigenin on Cell Viability, Colony-Forming Efficiency, and Ferroptosis via Methyltransferase-Like 14-Mediated m6A Modification of Solute Carrier Family 7 Member 11 in Human Epidermal Growth Factor Receptor 2-Enriched and Basal-Like Breast Cancer [0.03%]
异拉普苷 genin通过甲基转移酶样蛋白14介导的Solute Carrier家族7成员11的m6A修饰对人表皮生长因子受体2富集型和基底样乳腺癌细胞活力、集落形成效率和铁死亡的影响
Zhong Li,Zhongji Zhang,Xi Lin
Zhong Li
As a key regulator of N6-methyladenosine (m6A) modification, methyltransferase-like 14 (METTL14) has been implicated in the progression of various cancers; however, its functional role in breast cancer remains controversial. Isorhapontigeni...
Clinical and Molecular Features of BAP1-Mutated Meningiomas: Case Series [0.03%]
BAP1基因突变型脑膜瘤的临床和分子特征：病例系列报告
Ivan Pradilla,Rasha Alfattal,Susan L McGovern et al.
Ivan Pradilla et al.
BRCA1-associated protein 1 (BAP1)-deficient meningiomas represent a clinically and molecularly distinct subgroup with variable histology and aggressive behavior that may not be fully captured by current grading criteria. The clinical spectr...
The CRABP2-MDK Signaling Axis Promotes Lung Adenocarcinoma (LUAD) Progression and Highlights Prognostic Biomarkers [0.03%]
CRABP2-MDK信号轴促进肺腺癌(LUAD)进展并揭示预后生物标志物
Jingshun Zhang,Cui Zhang,Guopeng Jiang et al.
Jingshun Zhang et al.
Lung cancer is the leading cause of cancer-related mortality worldwide, with LUAD being characterized by high incidence and mortality rates. Despite the use of various treatments, including surgery, chemotherapy, immunotherapy, and molecula...
SFRP2+ CAFs Expressing Myofibroblastic Phenotype Are Involved in Glutamine Metabolism and Malignant Behaviors of Laryngeal Squamous Cell Carcinoma by Collaborating With ELAVL1 to Stabilize GID8 mRNA [0.03%]
SFRP2+CAF通过与ELAVL1合作稳定GID8 mRNA参与喉鳞状细胞癌谷氨酰胺代谢及恶性行为中的肌成纤维母细胞表型的作用机制研究
Bo Pang,Ying Zhang
Bo Pang
Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to meet the demands of rapid growth and survival. Within tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) influence tumor metabolism through metabolic c...
ZNF695 Promotes Colorectal Cancer Progression Through Transcriptional Activation of CBX8 and Subsequent Wnt/β-Catenin Signaling Activation [0.03%]
锌指蛋白695通过转录激活CBX8促进结直肠癌进展及Wnt/β-catenin信号途径活化
Xiaozhun Tang,Hailin Ke,Ying Huang
Xiaozhun Tang
In this investigation, we examined the functional mechanism of the transcription factor zinc finger protein 695 (ZNF695) and its target gene chromobox protein homolog 8 (CBX8) in colorectal cancer (CRC) migration and invasion. HCT-116 and L...
IL-24 Induces Cell Dormancy and Oxaliplatin Resistance in Colon Cancer Cells by Activating NF-κB Pathway [0.03%]
通过激活NF-κB途径诱导结肠癌细胞休眠和奥沙利铂耐药性 IL-24诱导结肠癌细胞休眠及顺铂抗性的新机制：NF-κB信号通路被激活
Yanyan Hu,Shengying Li,Minjing Zhu et al.
Yanyan Hu et al.
Oxaliplatin-based chemotherapy is a principal treatment for colon cancer, but drug resistance hinders its efficacy. Cancer cell dormancy is reportedly a crucial driver of chemoresistance. IL-24 functions vitally in tumor chemoresistance, ye...
PACT Inhibits Malignant Biological Behavior of Ovarian Cancer Cells by Regulating TERT Expression [0.03%]
PACT通过调节TERT表达抑制卵巢癌细胞恶性生物学行为
Xuemei Yang,Qian Zhang,Xiaofeng Yang et al.
Xuemei Yang et al.
Ovarian cancer (OC) is a lethal malignancy with limited treatment options. While p53-associated cellular protein-testes derived (PACT) has been implicated in cellular stress responses, its role in OC progression and the regulation of ferrop...
Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence [0.03%]
酰基甘油激酶通过限制线粒体损伤相关细胞衰老使胶质母细胞瘤对替莫唑胺敏感
Na Ning,Changtu Wang,Tingyu Gao et al.
Na Ning et al.
Temozolomide (TMZ) is still the first-line drug for glioblastoma (GBM) treatment though tumor cell resistance remains a major challenge. TMZ administration may induce cellular senescence (CSEN), which exerts a dual regulatory effect on tumo...