Structural Architecture and Evolutionary Conservation of Cerebellin-Mediated Trans-Synaptic Signaling [0.03%]
cerebellin 表达介导的跨突触信号转导的结构框架及其进化保守性
Panfeng Zhao,Jian Yang,Jie Yang et al.
Panfeng Zhao et al.
The cerebellin (CBLN) family includes CBLN1, CBLN2, CBLN3, and CBLN4, which are important secreted glycoproteins that play roles in synaptogenesis and the maintenance and plasticity of synapses across various regions of the central nervous ...
Effect of Healthy Aging on the Cytoarchitecture of Layer V Pyramidal Neurons in the Motor Cortex of Rats: A Golgi Study [0.03%]
健康老化对大鼠运动皮层V层锥体神经元细胞构筑的影响：高尔基染色研究
David González-Tapia,Nallely Vázquez-Hernández,Ignacio González-Burgos
David González-Tapia
In recent decades, the rate of aging has increased significantly worldwide. Since both cognitive and motor performance decline during aging, they are considered indicators of this stage of normal development. Successful, healthy aging-not a...
Ketamine Responsiveness of Mice Exhibiting Anorexia-Like Behavior Correlates With Synaptic AMPA Receptor Distribution [0.03%]
小鼠厌食样行为的氯胺酮反应与突触AMPA受体分布相关性研究
Bridget Xu,Cassandra Carrasco,Yi-Wen Chen et al.
Bridget Xu et al.
Anorexia nervosa is a deadly eating disorder marked by extreme food restriction, compulsive exercise, and severe weight loss. In a prior study using the activity-based anorexia (ABA) animal model of anorexia nervosa, 30 mg/kg, but not 3 mg/...
Measurement of Tau Protein and Aβ Amyloid Plaques in Postmortem Human Brains of Down Syndrome and Alzheimer's Disease by Using [125I]IPPI and [125I]IBETA Autoradiography [0.03%]
使用[125I]IPPI和[125I]IBETA自体放射法测定唐氏综合症和阿尔茨海默病死者脑中Tau蛋白和Aβ淀粉样斑块的方法
Agnes P Biju,Fariha Karim,Deanna M Schafer et al.
Agnes P Biju et al.
The accumulation of tau tangles and Aβ plaques are prominent neuropathologies that characterize Alzheimer's disease (AD) and Down syndrome (DS). Continuous developments of PET tracers as biomarkers can be supported by autoradiography to va...
Sevoflurane Triggers Glial Cell Damage Through BLACAT1/miR-361-3p Axis Resulting in Cognitive Impairment [0.03%]
异氟醚通过BLACAT1/miR-361-3p轴触发胶质细胞损伤导致认知障碍
Jipeng Wen,Feiyu Long,Xiaoying Wang
Jipeng Wen
To investigate the regulatory mechanism of BLACAT1 expression in sevoflurane (Sev)-induced neuronal cell injury. An in vitro model was created by treating microglial cell lines with 3% Sev. An in vivo model was created by administering 2.2%...
Protective Role of miR-3909 Against Propofol-Induced Neurotoxicity Through the Regulation of Polymerase I and Transcript Release Factor [0.03%]
miR-3909通过调节RNA聚合酶I和转录释放因子对抗丙泊酚诱导的神经毒性的作用
Xiangyu Lu,Yuanzhu Li,Haitao Lou et al.
Xiangyu Lu et al.
Propofol (PPF), a commonly employed clinical anesthetic, has elicited growing concern due to its associated neurotoxic effects. However, the functional role and mechanistic insights of microRNA-3909 (miR-3909) in PPF-induced neurotoxicity r...
Multi-Omics Dissection of the Role of Ubiquitination Modification in Post-Stroke Neuroinflammation and Function Damage [0.03%]
泛素化修饰在缺血性脑卒中后神经炎症和功能损伤中的作用机制及多组学解析研究
Peng Yao,Dan Li
Peng Yao
Objective: This study aims to explore the role of ubiquitination in neuroinflammation and functional damage after stroke using multi-omics analysis, focusing on the pathways influenced by ubiquitination. ...
Resveratrol Improves Fine Motor Performance and Attenuates Oxidative Stress, GFAP Reactivity, and Purkinje Cell Loss in the Cerebellum of Male Rats After 12, 18, and 24 Months of Treatment [0.03%]
白藜芦醇改善雄性大鼠12、18和24个月治疗后小脑精细运动能力并减轻氧化应激、GFAP反应性和浦肯野细胞丢失
Daniel Juarez,Berenice Venegas,Dalia Molina-Romero et al.
Daniel Juarez et al.
The cerebellum contributes to motor, cognitive, and affective functions that progressively decline with aging. The search for effective therapies to delay age-related degeneration has become a focus of the scientific community. Resveratrol,...
Role and Mechanism of miR-101b-3p via Targeting TXNIP in Sevoflurane-Induced Cognitive Impairment in Mice [0.03%]
miR-101b-3p在异氟烷诱导的小鼠认知障碍中的作用及机制：靶向TXNIP的作用路径
Haitao Lou,Haibo Yang,Feifei Chen
Haitao Lou
Sevoflurane may trigger neuroinflammation, thereby leading to cognitive dysfunction. This study aimed to investigate the mechanism of microRNA-101b-3p (miR-101b-3p) in sevoflurane-induced hippocampal neurodegeneration. In this study, 48 mal...