Antidiarrheal, vasorelaxant, and neuropharmacological actions of the diterpene tilifodiolide [0.03%]
齐墩果烷二萜化合物tilifodiolide的止泻、血管松弛和神经药理学作用研究
Clara Alba-Betancourt,Amanda Sánchez-Recillas,Angel J Alonso-Castro et al.
Clara Alba-Betancourt et al.
Salvia tiliifolia is used in folk medicine as a relaxant agent and for the treatment of diarrhea and neurodegenerative diseases. Tilifodiolide (TFD) is a diterpene obtained from this plant. The purpose of this work was to evaluate the antid...
Anticancer activity of newly synthesized 1,1-disubstituted cyclohexane-1-carboxamides: in vitro caspases mediated apoptosis activators in human cancer cell lines and their molecular modeling [0.03%]
新型合成的1,1-双取代环己烷-1-羧酰胺类化合物的抗肿瘤活性：体外人癌细胞系中的半胱天冬酶介导的凋亡激活剂及其分子建模研究
Walaa Hamada Abd-Allah,Asmaa Salman,Samah Sabry Saad
Walaa Hamada Abd-Allah
Novel 1,1-disubstituted cyclohexane-1-carboxamides 6a-h, 7a-e, and 8a-b were designed and synthesized as apoptotic inducers. Cytotoxicity test revealed that some compounds have strong to moderate effect, while others displayed weak action a...
Mucosal gene expression changes induced by anti-TNF treatment in inflammatory bowel disease patients [0.03%]
抗TNF治疗诱导炎症性肠病患者粘膜基因表达变化
Elena Milanesi,Maria Dobre,Teodora E Manuc et al.
Elena Milanesi et al.
In the last two decades anti-tumor necrosis factor (anti-TNF) therapy for inflammatory bowel disease (IBD) has been widely used to induce and maintain clinical and endoscopical remission, completely changing management of the disease. In th...
Effect of IS01957, a para-coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy [0.03%]
一种新的间耦马酸衍生物IS01957通过口服途径对改善消炎痛药代动力学的影响研究以增强疗效
Anjna Sharma,Abhishek Gour,Shipra Bhatt et al.
Anjna Sharma et al.
Diclofenac is one of the world's largest selling nonsteroidal anti-inflammatory drugs. The major concerns related to oral diclofenac therapy are gastrointestinal and cardiovascular side effects for which explicitly emphasis has been given t...
The protective effect of syringic acid on dextran sulfate sodium-induced experimental colitis in BALB/c mice [0.03%]
丁酸钠致BALB/c小鼠结肠炎模型中香草酸的保护作用研究
Wenhui Fang,Shihong Zhu,Zhongbao Niu et al.
Wenhui Fang et al.
Inflammatory bowel diseases involve chronic intestinal inflammation which is mostly caused by Crohn's disease and ulcerative colitis (UC) conditions. Patients having UC are prone to colorectal cancer and dysplastic polyps, and also have spo...
Preventive effect of nerolidol on isoproterenol induced myocardial damage in Wistar rats: Evidences from biochemical and histopathological studies [0.03%]
Nerolidol对异丙肾上腺素所致Wistar大鼠心肌损伤的预防作用：生化和组织病理学证据
Loordhurani Asaikumar,Lakshmanan Vennila,Palaniyandi Akila et al.
Loordhurani Asaikumar et al.
The present study aimed at investigating the protective effects of nerolidol (NRD) against myocardial infarction (MI) induced by isoproterenol (ISO) in Wistar rats. The rats were randomly divided into five groups, each group consisting of s...
Dose-dependent chemopreventive effects of citronellol in DMBA-induced breast cancer among rats [0.03%]
柠檬醇的剂量依赖性化学预防效果评价：DMBA致大鼠乳腺癌模型中的作用
Jayaganesh Rajendran,Pugalendhi Pachaiappan,Suganthi Subramaniyan
Jayaganesh Rajendran
Breast cancer is one of the most common cancers among women world wide and its incidence is on tremendous increase. The present study is aimed to analyze the dose-dependent chemopreventive efficacy of citronellol on 7,12-dimethylbenz(a)anth...
Effectiveness of nalbuphine, a κ-opioid receptor agonist and μ-opioid receptor antagonist, in the inhibition of INa , IK(M) , and IK(erg) unlinked to interaction with opioid receptors [0.03%]
nalbuphine（κ-阿片受体激动剂和μ-阿片受体拮抗剂）抑制INaa，IK(M)a以及IK(erg)a的有效性与作用于阿片受体无关
Yuan-Yuarn Liu,Hung-Tsung Hsiao,Jeffery C-F Wang et al.
Yuan-Yuarn Liu et al.
Nalbuphine (NAL) is recognized as a mixer with the κ-opioid receptor agonist and the μ-opioid receptor antagonist. However, whether this drug causes any modifications in neuronal ionic currents is unclear. The effects of NAL on ionic curr...
Dimethylaminoparthenolide reduces the incidence of dysplasia and ameliorates a wasting syndrome in HPV16-transgenic mice [0.03%]
脱毒白术内酯乙减少HPV16-Tg小鼠不典型增生及改善恶病质症状
Joana M O Santos,Alexandra Moreira-Pais,Tiago Neto et al.
Joana M O Santos et al.
The nuclear factor kappa light chain enhancer of activated B cells (NF-κB) has been implicated in the progression of cancers induced by high-risk human papillomaviruses (HPV). In cancer patients, NF-κB is also thought to drive a chronic s...
Novel steroid sulfatase inhibitors based on N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates [0.03%]
基于N-硫磷酰化3-(4-氨基苯基)香豆素-7-O-磺胺酸的新型类固醇硫酸酯抑制剂
Mateusz Daśko,Sebastian Demkowicz,Karol Biernacki et al.
Mateusz Daśko et al.
In the present work, we described convenient methods for the synthesis of N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates as steroid sulfatase (STS) inhibitors. To design the structures of the potential STS inhibitors, molecu...