Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2-induced PSMB5 in endothelial cells [0.03%]
番石榴茋A通过Nrf2诱导的PSMB5抑制线粒体分裂并促进Drp1降解作用于内皮细胞
Yingchao Zhu,Ming Li,Yawen Lu et al.
Yingchao Zhu et al.
Atherosclerosis (AS) is one of important events involving in the pathological process of coronary artery disease. Many traditional Chinese medicines have been widely used for the treatment of AS. Previous studies have demonstrated that Ilex...
Anti-neuroinflammatory effects of tannic acid against lipopolysaccharide-induced BV2 microglial cells via inhibition of NF-κB activation [0.03%]
鞣酸通过抑制NF-κB激活对抗脂多糖诱导的BV2微胶质细胞的抗神经炎症作用
Yan Wu,Lianmei Zhong,Zeran Yu et al.
Yan Wu et al.
Microglia mediated neuroinflammation is known to cause various neurodegenerative and neurological ailments. Tannic acid is a natural polyphenol which has been reported to possess antioxidant, anti-inflammatory, anticarcinogenic, antimutagen...
Protective role of sitagliptin against oxidative stress in a kainic acid-induced status epilepticus in rats models via Nrf2/HO-1 pathway [0.03%]
西格列汀通过Nrf2/HO-1通路对抗氧化应激保护KA诱导的SE大鼠模型的作用研究
Chong-Hao Wang,Na Zhu
Chong-Hao Wang
Aim: Sitagliptin (Sita) is a dipeptidyl peptidase-4 inhibitor which has been approved as a curing medicine for Type 2 diabetes (T2D) and has also reported its neuroprotective and antioxidant activity. This article describ...
Can acetaminophen/dimethyl sulfoxide formulation prevent accidental and intentional acetaminophen hepatotoxicity? [0.03%]
对乙酰氨基酚/二甲亚砜剂型能预防意外和故意引起的对乙酰氨基酚所致肝毒性吗？
Saleh G Algfeley,Salim S Al-Rejaie,Mahmoud N Nagi
Saleh G Algfeley
An overdose of acetaminophen (APAP) causes liver injury in experimental animals and humans. The activation step (formation of reactive metabolite, N-acetyl-p-benzoquinone imine by cytochrome P450 system) and the consequent downstream pathwa...
Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-κB pathways in human hepatocellular carcinoma cells [0.03%]
异甘草素通过ROS介导的MAPK/STAT3/NF-κB途径诱导人肝癌细胞凋亡和周期阻滞的机制研究
Jia-Ru Wang,Ying-Hua Luo,Xian-Ji Piao et al.
Jia-Ru Wang et al.
Isoliquiritigenin (ISL), a natural flavonoid isolated from plant licorice, has various pharmacological properties, including anticancer, anti-inflammatory, and antiviral effects. However, the underlying mechanisms and signaling pathways of ...
Anticonvulsant evaluation and docking analysis of VV-Hemorphin-5 analogues [0.03%]
VV-镇痛五肽类似物的抗惊厥作用评价及分子对接分析研究
Petar Todorov,Miroslav Rangelov,Petia Peneva et al.
Petar Todorov et al.
VV-Hemorphin-5 is an endogenous opioid peptide of the Hemorphin family with affinity at opioid receptors. A series of C-amide analogues have been synthesized, based on the structure of VV-Hemorphin-5, modified at position 1 and 7 by the un/...
Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition [0.03%]
取代基氟或氯肉桂酸三甲胺侧链衍生物乙酰胆碱酯酶和丁酰胆碱酯酶抑制结构活性研究
Xiao-Hui Gao,Jing-Jing Tang,Hao-Ran Liu et al.
Xiao-Hui Gao et al.
In this study, a series of new fluorine or chlorine-substituted cinnamic acid derivatives that contain tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhib...
Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF-κB signal pathway [0.03%]
姜黄素通过抑制TLR4/MyD88/NF-κB信号通路减少膝骨关节炎大鼠炎症反应
Yun Zhang,Yu Zeng
Yun Zhang
Preclinical Research & Development Curcumin has been shown to possess a series of beneficial effects, such as antiinflammatory, antioxidant, analgesic, and promoting healing. However, the effect and relative mechanism of curcumin on knee os...
Inhibition of angiogenesis and tumor growth by a novel 1,4-naphthoquinone derivative [0.03%]
一种新型的1,4-萘醌衍生物对血管生成和肿瘤生长的抑制作用
Hiroko Murota,Tomohiro Shinya,Arisa Nishiuchi et al.
Hiroko Murota et al.
Hit, Lead & Candidate Discovery Antiangiogenesis therapy is a promising way for treatment of solid cancers, and many angiogenesis inhibitors that target vascular endothelial growth factor (VEGF) or its receptors have been developed. We expl...
Investigation of the antibacterial and antifungal activity of thiolated naphthoquinones [0.03%]
硫化萘醌抗菌和抗真菌活性的研究
Kevin W Wellington,Nomgqibelo B P Nyoka,Lyndy J McGaw
Kevin W Wellington
The WHO has stated that antibiotic resistance is escalating to perilously high levels globally and that traditional therapies of antimicrobial drugs are futile against infections caused by resistant microorganisms. Novel antimicrobial drugs...