Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma [0.03%]
载伊马替尼和 Dexketoprofen 的靶向脂质体和纳米耳状复合物对肉瘤的疗效研究
Özlem Çoban,Zelihagül Değim,Şükran Yılmaz et al.
Özlem Çoban et al.
The main challenges in treating cancer using chemotherapeutics are insufficient dose at the target site and the development of drug resistance, while higher doses can induce side effects by damaging nontarget tissues. Combinatorial drug the...
Mine Silindir-Gunay,Elif Tugce Sarcan,Asuman Yekta Ozer
Mine Silindir-Gunay
Developments in fluorescence imaging, brought popularity to near infrared (NIR) imaging with far-red and NIR fluorophores applied for biosensing and bioimaging in living systems. Noninvasive NIR imaging gained popularity with the use of eff...
Joshua O Odingo,Julie V Early,Jake Smith et al.
Joshua O Odingo et al.
There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8-hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities. ...
Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats [0.03%]
茋醌酚胶束溶液通过TLR4和MAPK信号通路改善心肌梗死大鼠线粒体功能紊乱的研究
Canzhan Zhu,Wanjing Li,Xinhong Wang et al.
Canzhan Zhu et al.
Myocardial infarction (MI) is indicated by the symptoms like sharp chest pain, sweating, palpitations, and nervousness finally leading to heart attack. MI occurs mainly due to the risk factors like smoking, elevated blood pressure, diabetes...
The protective effect of kaempferol on heart via the regulation of Nrf2, NF-κβ, and PI3K/Akt/GSK-3β signaling pathways in isoproterenol-induced heart failure in diabetic rats [0.03%]
染料木黄酮通过调节Nrf2、NF-κβ以及PI3K/Akt/GSK-3β信号通路对异丙肾上腺素诱导的糖尿病大鼠心肌损伤的保护作用研究
Long Zhang,Zhaoxia Guo,Yan Wang et al.
Long Zhang et al.
This study was designed to delineate the effect of kaempferol (KF) on heart failure (HF) in diabetic rats. Streptozotocin-induced male diabetic rats received KF orally at 10 and 20 mg/kg for 42 consecutive days. In last 2 days of the experi...
Cristazine, a novel dioxopiperazine alkaloid, induces apoptosis via the death receptor pathway in A431 cells [0.03%]
新颖的倍半氧桥环生物碱Cristazine通过死亡受体途径诱导A431细胞凋亡
Mi Jeong Jo,Maheshkumar P Patil,Hyun Il Jung et al.
Mi Jeong Jo et al.
The fungus Chaetomium sp. is a causative agent of infections in humans and is ubiquitous in the natural environment. The secondary metabolites of this genus exhibit many biological activities, including antifungal activity and toxicity in m...
What lurks in the shadows of the openness hyperbole for biopharmaceuticals? [0.03%]
生物制药的开放性 hyperbole 阴影中潜伏着什么？
R Neethu,Timo Minssen
R Neethu
Recent advances in transparency initiative signify laudable developments. Yet, a closer look on the legal developments indicates that commercially confidential information and personal data will continue to pose persisting challenges for cl...
Transcriptome analysis predicts mode of action of benzimidazole molecules against Staphylococcus aureus UAMS-1 [0.03%]
转录组分析预测苯并咪唑分子作用于金黄色葡萄球菌UAMS-1的抑菌机制
Deepika Chauhan,Santanu Hati,Richa Priyadarshini et al.
Deepika Chauhan et al.
Antimicrobial drug resistance is one of the most critical problems that plagued the human race in modern times. Discovery of novel antibiotics is important to counter this threat. Accordingly, herein we have reported the discovery of substi...
Barbara De Filippis,Alessandra Ammazzalorso,Rosa Amoroso et al.
Barbara De Filippis et al.
The high incidence and mortality of invasive fungal infections and serious drug resistance have become a global public health issue. There is an urgent need for alternative antimicrobials to control fungal infections and targeting it by ant...
Pharmacological interaction between NSAIDS with clomipramine and risperidone in mice visceral pain [0.03%]
在小鼠内脏疼痛中NSAIDs与氯米帕明和利培酮的药理学相互作用研究
Claudio Gonzalez Vargas,Hugo F Miranda,Fernando Sierralta et al.
Claudio Gonzalez Vargas et al.
Nonsteroidal anti-inflammatory drugs (NSAIDs) possess as primary action mechanism the inhibition of cyclooxygenases (COX-1, COX-2, and COX-3), thus producing a decreasing prostaglandin synthesis. This study was designed to evaluate whether ...