Discovery of natural naphthoquinones as sortase A inhibitors and potential anti-infective solutions against Staphylococcus aureus [0.03%]
一种天然萘醌类分 SORTASE A 抑制剂可作为抗金黄色葡萄球菌感染的潜在药物
Georgiana Nitulescu,Dragos P Mihai,Isabela M Nicorescu et al.
Georgiana Nitulescu et al.
Three natural naphthoquinones were screened to find new anti-virulence agents as inhibitors against sortase A from Staphylococcus aureus (SaSrtA) by quantifying the increase in fluorescence intensity upon substrate cleavage at various conce...
Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains [0.03%]
利用机器学习和生物物理选择最小细菌素结构域进行新型抗菌肽的发现
Francisco R Fields,Stefan D Freed,Katelyn E Carothers et al.
Francisco R Fields et al.
Bacteriocins, the ribosomally produced antimicrobial peptides of bacteria, represent an untapped source of promising antibiotic alternatives. However, bacteriocins display diverse mechanisms of action, a narrow spectrum of activity, and inh...
Neuroprotective effects of clavulanic acid following permanent bilateral common carotid artery occlusion in rats [0.03%]
克拉维酸钾对永久性双侧颈总动脉结扎大鼠的神经保护作用
Mustafa Ghanbarabadi,Farahnaz Falanji,Abolfazl Rad et al.
Mustafa Ghanbarabadi et al.
We investigated whether clavulanic acid could improve learning and memory, in rats underwent bilateral occlusion of common carotid artery (2VO). Seventy male Wistar rats were subjected to 2VO, with a 1-week interval between right and left a...
Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents [0.03%]
含腈化合物的合成、生物评价及分子模拟研究：作为抗阿尔茨海默药物的多靶点作用机制探索
Daniel Silva,Eduarda Mendes,Eleanor J Summers et al.
Daniel Silva et al.
Based on the monoamine oxidase (MAO) inhibition properties of aminoheterocycles with a carbonitrile group we have carried out a systematic exploration to discover new classes of carbonitriles endowed with dual MAO and AChE inhibitory activi...
Artesunate suppresses inflammation and oxidative stress in a rat model of colorectal cancer [0.03%]
艺术甜菊素抑制结直肠癌大鼠模型的炎症和氧化应激反应
Vijay L Kumar,Sneh Verma,Prasenjit Das
Vijay L Kumar
Anti-inflammatory drugs are well known to reduce the risk of colon cancer and prophylactic use of such agents is gaining acceptance as a cancer prevention therapy. As artesunate, an antimalarial drug, has been shown to exhibit chemopreventi...
Comparative Study
Drug development research. 2019 Dec;80(8):1089-1097. DOI:10.1002/ddr.21590 2019
Discovery of a new family of heterocyclic amine linked plastoquinone analogs for antimicrobial evaluation [0.03%]
一类异环胺类叶绿醌类似物的发现及其抗菌活性评价
Amaç F Tuyun,Mahmut Yıldız,Nilüfer Bayrak et al.
Amaç F Tuyun et al.
A series of aminobenzoquinones, denoted as PQ analogs (PQ1-13), were synthesized by employing a green methodology approach using water as solvent developed by Tandon et al. Subsequently, in vitro antimicrobial potential of all PQ analogs wa...
Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells [0.03%]
奎唑啉茋通过ROS介导的信号通路诱导人黑色素瘤A375细胞周期阻滞及凋亡
Ying-Hua Luo,Jin-Qian Li,Yi Zhang et al.
Ying-Hua Luo et al.
Quinalizarin, a bioactive and highly selective compound, is known to promote apoptosis in colon and lung cancer cells. However, studies evaluating quinalizarin-induced apoptosis in melanoma cells have not been conducted. In the present stud...
iRGD-paclitaxel conjugate nanoparticles for targeted paclitaxel delivery [0.03%]
用于定点递送紫杉醇的iRGD-紫杉醇连接物纳米颗粒
Hang Hu,Bin Wang,Chao Lai et al.
Hang Hu et al.
Paclitaxel (PTX) is a chemotherapeutic agent which shows antitumor activities against a broad spectrum of cancers. Yet, the current formulation of PTX used in clinic may cause a number of adverse reactions, which significantly limit its app...
Involvement of l-arginine-nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice [0.03%]
芦丁通过l-精氨酸一氮氧化物信号通路发挥抗抑郁和改善认知的作用
Benneth Ben-Azu,Adegbuyi O Aderibigbe,Abayomi M Ajayi et al.
Benneth Ben-Azu et al.
l-Arginine-nitric oxide pathway has been reported to be involved in the mediation of the psychopharmacological effects of many psychotropic drugs. Previous studies have shown that morin, a psychotropic compound isolated from mulberry leaf p...
Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression [0.03%]
姜黄素通过上调CD109的表达减轻胆管上皮细胞的上皮间质转化
Junyu Fan,Qian Wang,Zhuoya Zhang et al.
Junyu Fan et al.
Biliary epithelial cells (BECs) can secrete bile and the epithelial-to-mesenchymal transition (EMT) of BECs can cause fibrosis or damage interlobular bile ducts, leading to chronic cholangiopathies, such as primary biliary cholangitis (PBC)...