Synthesis and cytotoxic evaluation of apioarabinofuranosyl pyrimidines [0.03%]
2'-阿拉伯呋喃糖基阿普碘苷核甘类似物的合成及其细胞毒性检测
Balija Sivakrishna,Sehbanul Islam,Manas K Santra et al.
Balija Sivakrishna et al.
In view of the potent anticancer activity of the d-arabino-configured cytosine nucleoside (ara-C), apioarabinofuranosyl pyrimidine nucleosides were designed and synthesized from d-ribose as starting material. The synthetic strategy signifie...
Chronic administration of Cl-amidine, a pan-peptidylarginine deiminase inhibitor, does not reverse bone loss in two different murine models of osteoporosis [0.03%]
克拉密叮慢性给药不能逆转两种不同小鼠骨质疏松模型中的骨丢失现象
Virginia M Vargas-Muñoz,Arisai Martínez-Martínez,Enriqueta Muñoz-Islas et al.
Virginia M Vargas-Muñoz et al.
Recent in vitro studies have shown a role for the peptidyl-arginine deiminases (PADs) in bone resorption. However, it is unknown whether these enzymes are involved in bone loss in vivo. Thus, we evaluated the antiresorptive effect of a pan-...
A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants [0.03%]
抗抑郁药治疗下评估抑郁症严重程度的药物基因组学风险评分
Sofia H Kanders,Claudia Pisanu,Marcus Bandstein et al.
Sofia H Kanders et al.
The severity of symptoms as well as efficacy of antidepressants in major depressive disorder (MDD) is modified by single nucleotide polymorphisms (SNPs) in different genes, which may contribute in an additive or synergistic fashion. We aime...
Discovery of novel halogenated 8-hydroxyquinoline-based anti-MRSA agents: In vitro and QSAR studies [0.03%]
新型卤代8-羟基喹啉类抗MRSA药物的发现：体外和QSAR研究
Rungrot Cherdtrakulkiat,Apilak Worachartcheewan,Srisurang Tantimavanich et al.
Rungrot Cherdtrakulkiat et al.
Methicillin-resistant Staphylococcus aureus (MRSA) infection has been considered to be one of global health problems due to limited classes of effective antimicrobial drugs. Herein, 8-hydroxyquinoline (8HQ) and its derivatives (1-7) were in...
The use of aliskiren as an antifibrotic drug in experimental models: A systematic review [0.03%]
阿利舍雷宁作为抗纤维化药物在实验模型中应用的系统评价
Thainá Altarejo Marin,Bruno Machado Bertassoli,Alzira Alves de Siqueira de Carvalho et al.
Thainá Altarejo Marin et al.
Aliskiren is an oral antihypertensive medication that acts by directly inhibiting renin. High levels of circulating renin and prorenin activate the pathological signaling pathway of fibrosis. This drug also reduces oxidative stress. Thus, t...
In vitro and in vivo evaluation of radiolabeled methyl N-[5-(3'-halobenzoyl)-1H-benzimidazol-2-yl]carbamate for cancer radiotherapy [0.03%]
体外和体内放射标记甲基N-[5-(3'-卤代苯甲酰)-1H-苯并咪唑-2-基]碳酰胺用于癌症放疗的评估
Zbigniew P Kortylewicz,Don W Coulter,Janina Baranowska-Kortylewicz
Zbigniew P Kortylewicz
The role of theranostics in cancer management is growing so is the selection of vectors used to deliver these modalities to cancer cells. We describe biological evaluation of a novel theranostic agent targeted to microtubules. Methyl N-[5-(...
Novel histone deacetylase inhibitors bearing a 4-piperidin-4-yl-triazole scaffold as antitumor agents [0.03%]
一类新型组蛋白去乙酰化酶抑制剂抗肿瘤活性研究
Yan Wang,Li Su,Qiang Wang et al.
Yan Wang et al.
Histone deacetylases have proven to be promising targets for the development of anticancer drugs. In this work, we reported the design and synthesis of a series of 20 novel hydroxamic acid-based histone deacetylase inhibitors with 4-piperid...
SCN11A mRNA levels in female bipolar disorder PBMCs as tentative biomarker for distinct patient sub-phenotypes [0.03%]
SCN11A在女性双相情感障碍外周血单个核细胞中的mRNA水平作为特异性亚型的生物标志物尝试性研究
Irena Voinsky,Michael J McCarthy,Tatyana Shekhtman et al.
Irena Voinsky et al.
Bipolar disorder (BD) is a complex neuropsychiatric disorder characterized by recurrent mania and depression episodes and requiring lifelong treatment with mood stabilizing drugs. Several lines of evidence, including with BD patient iPSC-de...
A new potential anti-cancer beta-carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation [0.03%]
一种新的抗肿瘤β-碳啉衍生物可通过蛋白质组学研究降低胶质瘤恶性关键蛋白的表达水平
Annelise Carvalho,Johan Viaene,Guy Vandenbussche et al.
Annelise Carvalho et al.
Gliomas remain highly fatal due to their high resistance to current therapies. Deregulation of protein synthesis contributes to cancer onset and progression and is a source of rising interest for new drugs. CM16, a harmine derivative with p...
Vitexin ameliorates preeclampsia phenotypes by inhibiting TFPI-2 and HIF-1α/VEGF in a l-NAME induced rat model [0.03%]
黄环素通过抑制TFPI-2和HIF-1α/VEGF改善l-NAME诱导的子痫前期模型的作用及机制研究
Lili Zheng,Jing Huang,Yuan Su et al.
Lili Zheng et al.
Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality with few safe, effective, and minimally invasive therapeutics. Inflammation, oxidative stress, and angiogenic imbalance have been reported to contribute ...