Preclinical evaluation of a biobetter candidate: Pharmacokinetics and pharmacodynamics of GX-G3 in healthy and neutropenia-induced rats [0.03%]
GX-G3在健康和中性粒细胞减少大鼠体内的药代动力学及药效学的临床前评估研究
Yun Jung Kim,Senem Ertan-Ahmed,Yilmaz Capan et al.
Yun Jung Kim et al.
Neutropenia is a condition of an abnormally low number of neutrophils which render patients more susceptible to infections, especially to bacterial infections, as the condition may become life threatening and deadly without prompt medical a...
Anti-inflammatory and diuretic effects of the diterpene ent-dihydrotucumanoic acid [0.03%]
ent-二氢土大黄酸的抗炎和利尿作用
Angel Josabad Alonso-Castro,Víctor E Arana-Argáez,Martha Alicia Deveze-Alvarez et al.
Angel Josabad Alonso-Castro et al.
Gymnosperma glutinosum (Spreng) Less (Asteraceae) is a shrub used in traditional medicine for the treatment of inflammatory and renal diseases. The ent-dihydrotucumanoic acid (DTA) is a diterpene obtained from G. glutinosum. This study eval...
Synergistic terpene combinations as larvicides against the dengue vector Aedes aegypti Linn [0.03%]
蚊虫组合萜烯类化合物对登革热媒介埃及伊蚊的杀幼效用研究
Sivajaya Ragul Dhinakaran,Nisha Mathew,Sundharesan Munusamy
Sivajaya Ragul Dhinakaran
Most of the essential oils (EO) known for mosquitocidal activity contain terpenes as part of their chemical constituents. In this study, four monoterpenes namely γ-terpinene (T), R-(+)-limonene (L), carvacrol (C), and trans-anethole (A) we...
Schiff base-nickel, palladium, and platinum complexes derived from N-cyclohexyl hydrazine carbothioamide and 3-hydroxy-4-methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma [0.03%]
N-环己基肼羰基硫胺和3-羟基-4-甲氧基苯甲醛衍生的希夫碱-镍、钯和铂复合物：对结直肠癌的选择性抗增殖和促凋亡作用
Md Azharul Arafath,Fouad S R Al-Suede,Farook Adam et al.
Md Azharul Arafath et al.
The bidentate N-cyclohexyl-2-(3-hydroxy-4-methoxybenzylidene)hydrazine-1-carbothioamide Schiff base ligand (HL) was coordinated to divalent nickel, palladium and platinum ions to form square planar complexes. The nickel and palladium comple...
Novel analogs of sulfasalazine as system xc- antiporter inhibitors: Insights from the molecular modeling studies [0.03%]
基于分子模拟研究的柳氮磺胺吡啶类似物的新系统xc-反向转运蛋白抑制剂
Dhavalkumar Patel,Prashant S Kharkar,Neha S Gandhi et al.
Dhavalkumar Patel et al.
System xc- (Sxc- ), a cystine-glutamate antiporter, is established as an interesting target for the treatment of several pathologies including epileptic seizures, glioma, neurodegenerative diseases, and multiple sclerosis. Erastin, sorafeni...
Modified benzoxazolone (ABO-AA) based single photon emission computed tomography (SPECT) probes for 18 kDa translocator protein [0.03%]
基于苯并恶唑酮（ABO-AA）的单光子发射计算机断层扫描（SPECT）探针检测18kDa转位蛋白
Pooja Srivastava,Dipti Kakkar,Pravir Kumar et al.
Pooja Srivastava et al.
Acetamidobenzoxazolone (ABO) has been modified to ABO-AA, 2-(2-(5-bromo/chloro benzoxazolone)acetamide)-3-(1H-indol-3-yl)propionate to improve pharmacokinetics and lipophilicity (log p = 2.04). The final compound was synthesized in better y...
Design and synthesis of 2-hydroxyl-4-methoxyl-3-(3-methylbut-2-en-1-yl)-6-(4-phenylbenzoylamino)benzoic acid derivatives as antibacterial agents based on cajaninstilbene acid scaffold hopping [0.03%]
基于卡雅尼 stilbene 酸支架跳转的抗菌剂2-羟基-4-甲氧基-3-(3-甲基丁-2-烯-1-基)-6-(4-苯基苯甲酰胺)苯甲酸衍生物的设计与合成
Chang Zheng,Wen Hou,Jun Liu et al.
Chang Zheng et al.
The prevalence of multidrug resistance among clinically significant bacterial pathogens underlines a critical need for the development of new classes of antibacterial agents with novel structural scaffolds. Cajaninstilbene acid (CSA), which...
Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems [0.03%]
叶酸修饰的药物递送系统中的药用载体纳米颗粒研究进展
Asghar Narmani,Melina Rezvani,Bagher Farhood et al.
Asghar Narmani et al.
Conventional chemotherapeutic approaches in cancer therapy such as surgery, chemotherapy, and radiotherapy have several disadvantages due to their nontargeted distributions in the whole body. On the other hand, nanoparticles (NPs) based the...
Efficacy of a phenol derivative, isopropyl vanillate, as an anti-inflammatory agent: A new small molecule inhibitor of COX and neutrophil migration [0.03%]
苯酚衍生物异丙基香草酸作为抗炎剂的效果：一种新的环氧化酶和中性粒细胞迁移的小分子抑制剂
Kerolayne M Nogueira,Luan K M de Souza,Ana P de Oliveira et al.
Kerolayne M Nogueira et al.
Inflammation is the response of the body to noxious stimuli such as infections, trauma, or injury. Experimental studies have shown that vanillic acid has anti-inflammatory effects. The objective of this study was to investigate the anti-inf...
Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent [0.03%]
从_embelia ribes_鉴定出的针对多靶点抗阿尔茨海默病制剂embelin(3-十一烷基-1,4-苯醌)
Vijay K Nuthakki,Ankita Sharma,Ajay Kumar et al.
Vijay K Nuthakki et al.
Beta-secreatse (BACE-1) and cholinesterases are clinically validated targets of Alzheimer's disease (AD), for which natural products have provided immense contribution. The multifaceted nature of AD signifies the need of multitargeted agent...