Synthesis, molecular modeling studies, ADME prediction of arachidonic acid carbamate derivatives, and evaluation of their acetylcholinesterase activity [0.03%]
花生四烯酸碳酰胺衍生物的合成、分子模拟研究、ADME预测及其乙酰胆碱酯酶活性评价
Tugce N Kalin,Deryanur Kilic,Fatma Arslan et al.
Tugce N Kalin et al.
In this work, a series of novel anandamide units containing carbamate were designed and synthesized. All the derivatives were evaluated in vitro for their inhibitory potential against the electric eel acetylcholinesterase enzyme (AChE) and ...
Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs [0.03%]
抗体稳定和结晶的匹配ph值表明了生物药物加速开发的原理
Hanno Sjuts,Herman Schreuder,Christian K Engel et al.
Hanno Sjuts et al.
Monoclonal antibodies (mAbs) are currently leading products in the global biopharmaceutical market. Multiple mAbs are in clinical development and novel biotherapeutic protein scaffolds, based on the canonical immunoglobulin G (IgG) fold, ar...
Novel 5-(1-aryl-1H-pyrazol-3-yl)-1H-tetrazoles as glycogen phosphorylase inhibitors: An in vivo antihyperglycemic activity study [0.03%]
一种新型的糖原磷酸化酶抑制剂：体内外抗高血糖活性研究
Pramod P Kattimani,Shilpa M Somagond,Praveen K Bayannavar et al.
Pramod P Kattimani et al.
In this study, we report the ring transformation of 3-arylsydnone into 1-aryl-1H-pyrazole-3-carbonitriles via [3 + 2] cycloaddition with acrylonitrile. 1-Aryl-1H-pyrazole-3-carbonitrile underwent [2 + 3] cycloaddition with sodium azide to a...
Aza-CGP37157-lipoic hybrids designed as novel Nrf2-inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties [0.03%]
新型Nrf2诱导剂和抗氧化剂Azac-GCP37157-硫辛酸杂化物对氧化应激表现出神经保护作用并显示出神经炎症抑制特性
Patrycja Michalska,Giammarco Tenti,Michelle Satriani et al.
Patrycja Michalska et al.
Two multitarget hybrids, derived from an aza-analogue of CGP37157, a mitochondrial Na+ /Ca2+ exchanger antagonist, and lipoic acid were designed in order to combine in a single molecule the antioxidant and Nrf2 induction properties of lipoi...
L6H9 attenuates LPS-induced acute lung injury in rats through targeting MD2 [0.03%]
L6H9通过靶向MD2缓解脂多糖诱导的大鼠急性肺损伤
Peiliang Wu,Hanhan Yan,Jiayu Qi et al.
Peiliang Wu et al.
Acute lung injury (ALI) is a clinical syndrome characterized by respiratory failure and acute inflammatory response. Myeloid differentiation protein 2 (MD2) has been reported to play a pivotal role in the recognition of LPS and LPS-mediates...
The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress [0.03%]
siRNA药物输送在呼吸系统疾病中的潜力：近期进展和突破
Kamal Dua,Ridhima Wadhwa,Gautam Singhvi et al.
Kamal Dua et al.
Lung diseases are the leading cause of mortality worldwide. The currently available therapies are not sufficient, leading to the urgent need for new therapies with sustained anti-inflammatory effects. Small/short or silencing interfering RN...
CORRIGENDUM [0.03%]
勘误表
Published Erratum
Drug development research. 2019 Dec;80(8):1146. DOI:10.1002/ddr.21615
Leukocyte telomere length is reduced in patients with major depressive disorder [0.03%]
抑郁症患者的白细胞端粒长度缩短
Claudia Pisanu,Evangelia Eirini Tsermpini,Maria Skokou et al.
Claudia Pisanu et al.
Major depressive disorder (MDD) is a chronic, severe psychiatric illness with an incidence of 3% worldwide. MDD patients have a significantly impaired quality of life and reduced life expectancy compared to unaffected individuals, the latte...
Immunopharmacological effect of β-d-mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR-155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients [0.03%]
β-D-葡聚糖酸作为新的免疫抑制剂对类风湿关节炎患者miR-155及其靶分子(SOCS1、SHIP1)mRNA表达的影响研究
Seyed Shahabeddin Mortazavi-Jahromi,Mona Aslani,Saiedeh Omidian et al.
Seyed Shahabeddin Mortazavi-Jahromi et al.
The positive impacts of β-d-mannuronic acid (M2000) on the gene expression of miR-155, its target molecules (SOCS1 and SHIP1), and NF-κB transcription factor were demonstrated in a study using the HEK293-TLR2 cell line. This new drug has ...
Controlled Clinical Trial
Drug development research. 2020 May;81(3):295-304. DOI:10.1002/ddr.21619