Raghunandan Yendapally,Donald Sikazwe,Subin S Kim et al.
Raghunandan Yendapally et al.
Diabetes mellitus is a serious metabolic disorder affecting millions of people worldwide. Phenformin and metformin are biguanide antidiabetic agents that are conveniently synthesized in a single-step chemical reaction. Phenformin was once u...
Opportunities and challenges of using five-membered ring compounds as promising antitubercular agents [0.03%]
五元环化合物作为抗结核药物的机遇与挑战
Mi Yan,Linlin Xu,Yinhu Wang et al.
Mi Yan et al.
Tuberculosis (TB), a chronic infectious disease, is one of the greatest risks to human beings and 10 million people were diagnosed with TB and 1.6 million died from this disease in 2017. In addition, with the emergence of multidrug-resistan...
Oxalomalate regulates the apoptosis and insulin secretory capacity in streptozotocin-induced pancreatic β-cells [0.03%]
草酸苹果酸对链脲佐菌素诱导的胰岛β细胞凋亡及胰岛素分泌能力的影响
Suping Xin,Xinhua Ye
Suping Xin
Diabetes mellitus (DM) is a kind of metabolic disorder characterized by long-term hyperglycemia. Oxidative stress is involved in inducing the apoptosis of pancreatic β-cells and promoting the development of DM. Oxalomalate (OMA) is a compe...
Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: in vitro and in vivo evaluation [0.03%]
新型抗真菌活性的研究：通过将环丙沙星及其二元混合物封装在纳米组件中增强抗菌效力的体内和体外评价
Sally Abou Taleb,Asmaa Badawy Darwish,Amira Abood et al.
Sally Abou Taleb et al.
The main goal of this study was to prepare and evaluate nanosponges containing ciprofloxacin (CIP) or its binary mixture with N-acetyl carnosine (NAC). Nanosponges were prepared by ultrasound-assisted synthesis technique using hydroxypropyl...
Comparative Study
Drug development research. 2020 May;81(3):374-388. DOI:10.1002/ddr.21632 2020
Identification of two arylimides as cholinesterase inhibitors and testing of propranolol addition on impaired rat memory [0.03%]
两个芳基酰亚胺类胆碱酯酶抑制剂的鉴定及普萘洛尔对大鼠记忆损伤改善作用的研究
Fabiola J Ciprés-Flores,Eunice D Farfán-García,Erik Andrade-Jorge et al.
Fabiola J Ciprés-Flores et al.
Alzheimer's disease (AD) is clearly linked to the decline of acetylcholine (ACh) effects in the brain. These effects are regulated by the hydrolytic action of acetylcholinesterase (AChE). Therefore, a central palliative treatment of AD is t...
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives [0.03%]
兼具乙酰胆碱酯酶和淀粉样蛋白β抑制作用的吡啶
Harapriya Chakravarty,Yaojun Ju,Wen-Hua Chen et al.
Harapriya Chakravarty et al.
With the surge in the cases of Alzheimer's disease (AD) over the years, several targets have been explored to curb the disease. Cholinesterases, namely acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), remain to be the availabl...
Angiotensin II-induced micro RNA-21 culprit for non-small-cell lung adenocarcinoma [0.03%]
血管紧张素II诱导的微小核糖核酸-21是非小细胞肺癌腺癌元凶
Zhaoji Luan,Baoliang Liu,Lina Shi
Zhaoji Luan
Lung cancer is among the most complicated cancers, with an estimated 1.6 million deaths each year for both men and women. However, the proportion of lung cancer patients in developing nations has increased from 31% to 49.9% in the last two ...
Natalia V Naryzhnaya,Leonid N Maslov,Peter R Oeltgen
Natalia V Naryzhnaya
It is now firmly established that an important event in the formation of reperfusion injury of the heart is the opening of mitochondrial permeability transition pores (mPTPs), which changes the permeability of the mitochondria. mPTP opening...
Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease [0.03%]
糖尿病与阿尔茨海默病之间的认知功能障碍联系日益紧密
Kavya Jash,Piyush Gondaliya,Prathibha Kirave et al.
Kavya Jash et al.
Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting millions of people worldwide. Diabetes is associated with various complications like nephropathy, neuropathy, retinopathy, diabetic foot, cognitive ...
Natural products and their derivatives as multifunctional ligands against Alzheimer's disease [0.03%]
天然产物及其衍生物作为多功能配体用于对抗阿尔茨海默病
Pooja Patil,Ashima Thakur,Abha Sharma et al.
Pooja Patil et al.
Alzheimer's disease (AD), a complex neurodegenerative disorder causing multiple cellular changes including impaired cholinergic system, beta-amyloid (βA) aggregation, tau hyperphosphorylation, metal dyshomeostasis, neuroinflammation, and m...