Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases [0.03%]
新型药物输送系统在慢性呼吸系统疾病中针对中性粒细胞的应用
Dinesh K Chellappan,Lim W Yee,Kong Y Xuan et al.
Dinesh K Chellappan et al.
Neutrophils are essential effector cells of immune system for clearing the extracellular pathogens during inflammation and immune reactions. Neutrophils play a major role in chronic respiratory diseases. In respiratory diseases such as asth...
QSAR studies on benzothiophene derivatives as Plasmodium falciparum N-myristoyltransferase inhibitors: Molecular insights into affinity and selectivity [0.03%]
基于苯并噻吩衍生物的恶性疟原虫N-十四酰基转移酶抑制剂的_qsar_研究：亲和力与选择性的分子见解
Mariana L Garcia,Andrew A de Oliveira,Renata V Bueno et al.
Mariana L Garcia et al.
Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium and transmitted by Anopheles spp. mosquitos. Due to the emerging resistance to currently available drugs, great efforts must be invested in discovering n...
Published Erratum
Drug development research. 2020 Feb;81(1):136-137. DOI:10.1002/ddr.21614 2020
Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease [0.03%]
胰岛素抵抗和脂代谢障碍作为糖尿病和阿尔茨海默病之间潜在联系的纽带
Joshua A Kulas,Thaddeus K Weigel,Heather A Ferris
Joshua A Kulas
Diabetes disrupts organs throughout the body including the brain. Evidence suggests diabetes is a risk factor for Alzheimer's disease (AD) and neurodegeneration. In this review, we focus on understanding how diabetes contributes to the prog...
A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes [0.03%]
一种简单、稳健且经济的生物发光测定法，用于针对感染性非洲锥虫病的药物发现
Diego Benítez,Estefania Dibello,Mariana Bonilla et al.
Diego Benítez et al.
African trypanosomiasis is a major problem for human and animal health in endemic countries, where it threatens millions of people and affects economic development. New drugs are needed to overcome the toxicity, administration, low efficacy...
Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin-1 binding of small molecules [0.03%]
一类新型可供使用的化学荧光探针用于评价小分子与神经纤毛蛋白-1结合状况的研究发现
Daniel Conole,Yi-Tai Chou,Anastasia Patsiarika et al.
Daniel Conole et al.
Neuropilin-1 (NRP1) is emerging as an important molecule in immune signaling where it has been shown to modulate the actions of TGF-β1 in macrophages and regulatory T cells. The development of cost-effective and reliable assays for NRP1 bi...
Comparative Study
Drug development research. 2020 Jun;81(4):491-500. DOI:10.1002/ddr.21641 2020
Development and characterization of oxaceprol-loaded poly-lactide-co-glycolide nanoparticles for the treatment of osteoarthritis [0.03%]
用于治疗骨关节炎的载有oxaceprol的聚乳酸-羟基乙酸纳米颗粒的开发与表征
Emine Alarçin,Çağlar Demirbağ,Seher Karsli-Ceppioglu et al.
Emine Alarçin et al.
Oxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis. In the present study, we aimed to develop and characterize oxaceprol-loaded poly-lactide-co-glycolide (PLGA) nanoparticles for intra-art...
Selected pharmacotherapy agents as antiproliferative and anti-inflammatory compounds [0.03%]
几种药物作为抗增殖和抗炎化合物的作用研究
Mthanna AlKhalil,Yusuf Al-Hiari,Violet Kasabri et al.
Mthanna AlKhalil et al.
The repurposing of safe therapeutic drugs has emerged as an alternative approach to rapidly identify effective, safe, and conveniently available therapeutics to treat/prevent cancer. Therefore, it was hypothesized that acidic chelator drugs...
Comparative Study
Drug development research. 2020 Jun;81(4):470-490. DOI:10.1002/ddr.21640 2020
Novel 3-aryl-5-substituted-coumarin analogues: Synthesis and bioactivity profile [0.03%]
新型3-芳基-5-取代香豆素衍生物的合成及活性研究
Eleni Kavetsou,Annita Katopodi,Letta Argyri et al.
Eleni Kavetsou et al.
Eighteen 3-aryl-5-substituted-coumarins-six 5-acetyloxy-derivatives, six 5-hydroxy-derivatives, and six 5-geranyloxy-derivatives-were synthesized, structurally characterized and their antioxidant activity, lipoxygenase inhibitory ability, a...
Synthesis of novel flexible tamoxifen analogues to overcome CYP2D6 polymorphism and their biological evaluation on MCF-7 cell line [0.03%]
合成新型柔性的他莫昔芬类似物以克服CYP2D6多态性及其在MCF-7细胞系中的生物评价
Nermin S Ahmed,Jannette Wober
Nermin S Ahmed
Tamoxifen (TAM) is currently the endocrine treatment of choice for all stages of breast cancer; it has proven success in ER positive and ER negative patients. TAM is activated by endogenous CYP450 enzymes to the more biologically active met...
Comparative Study
Drug development research. 2020 Jun;81(4):444-455. DOI:10.1002/ddr.21637 2020