Synthesis and Biological Evaluation of π-Conjugated Ir(III) Complexes: Cytotoxic Potential, DNA/HSA Binding, Thermodynamics, and Antioxidant Activity [0.03%]
π共轭Ir(III)配合物的合成及生物活性评价：细胞毒性，DNA/HSA结合，热力学和抗氧化性能
Bhumika Joshi,Priyankar Paira,Kaliappan Uma et al.
Bhumika Joshi et al.
Metal-based complexes have greatly advanced anticancer therapy, but limitations of traditional drugs like cisplatin have driven the search for more stable and targeted metallodrugs. In this study, two novel Ir(III) complexes, PNIC and PNIT,...
Butyrate-Mediated Upregulation of Insulin Pathway Gene Expression Suggests Potential Antidiabetic Effects [0.03%]
丁酸介导的胰岛素途径基因表达上调可能具有潜在的抗糖尿病作用
Elad Shapira,Irena Voinsky,Hana Klin et al.
Elad Shapira et al.
Type 2 diabetes (T2D) is a major cause of morbidity in developed countries and involves insulin resistance, a failure to correctly respond to insulin. Numerous studies in rodent T2D models suggested that the short-chain fatty acid butyrate,...
Study on the Mechanism of Aspirin Alleviating Kawasaki Disease With Coronary Artery Lesions by Inducing TRAF6 to Regulate STAT3 Ubiquitination and Inhibit Th17 Cell Differentiation [0.03%]
阿司匹林治疗冠状动脉病变型川崎病的机制研究：通过诱导TRAF6调节STAT3泛素化抑制Th17细胞分化
Xiangzhen Qu,Weina Ma,Xiujie Ma et al.
Xiangzhen Qu et al.
Among multiple complications of Kawasaki disease (KD), coronary artery lesions (CALs) emerge as the clinically paramount concern. Aspirin therapy can reduce the incidence of KD with CAL, yet its mechanism remains unclear. This study princip...
rFIP-GMI Suppresses IGF-1-Induced Invasion and Migration in Breast Cancer Cells via PI3K/Akt/β-Catenin Inhibition [0.03%]
rFIP-GMI通过抑制PI3K/Akt/β-catenin信号通路抑制IGF-1诱导的乳腺癌细胞侵袭和迁移
Wen-Ling Liao,Yu-Ying Wu,Yu-Fan Liu et al.
Wen-Ling Liao et al.
Insulin-like growth factor-1 (IGF-I) promotes breast cancer (BC) progression by activating the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which enhances invasion and migration through β-catenin-mediated epithelial-mesenchymal transi...
Exploring the Analgesic and Antidiarrheal Properties of Angelicin Through Cyclooxygenase Inhibition and Μ-Opioid Receptor Interaction: In Vivo and In Silico Studies [0.03%]
通过环氧化酶抑制和μ-阿片受体相互作用探索当归敏的镇痛和止泻性质：体内和计算机模拟研究
Sourav Bagchi,Dipu Bishwas,Mst Muslima Khatun et al.
Sourav Bagchi et al.
Angelicin (AGN), an angular furocoumarin, exhibits notable anti-inflammatory and biological activities. However, its potential for managing pain and diarrhea, and the underlying mechanisms, remain poorly explored. This study aimed to invest...
Benzyl-Functionalised Imidazolium Ionic Liquids as Lead Candidates Against Human Breast Cancer: An Integrated In Vitro and In Silico Screening Approach [0.03%]
苄基功能化咪唑
Boon-Keat Khor,Jia En Lau,Fatini Syazana Sharul Azman et al.
Boon-Keat Khor et al.
The unique physicochemical and structural flexibility of ionic liquids (ILs) allows for fine modulation of biological activity, thus offering potential as the next-generation anticancer lead compounds with improved selectivity and efficacy....
Screening Natural Phenolic Compounds for Blood-Brain Barrier Permeability, Alongside GSK-3β, CK-1δ, and AChE Inhibition, for the Treatment of Alzheimer's Disease [0.03%]
针对阿尔茨海默病治疗的天然苯酚化合物血脑屏障通透性筛选，以及GSK-3β、CK-1δ和AChE抑制作用筛选
Perihan Gürbüz,Şengül Dilem Doğan,Miyase Gözde Gündüz et al.
Perihan Gürbüz et al.
Alzheimer's Disease (AD) is a neurological disorder characterized by progressive cognitive impairment and memory loss. In vitro artificial membrane permeability assays targeting the blood-brain barrier (BBB), such as the parallel artificial...
A Decade of Mitochondria-Targeting Drugs in Cancer Treatment: Case Review on Mitochondria-Targeting Curcumin or Mitocurcumin [0.03%]
靶向线粒体药物治疗癌症的十年：靶向线粒体姜黄素或米托姜黄素的案例分析
Rahul Shah,Ryan Varghese,Harsh Anchan et al.
Rahul Shah et al.
Mitochondrial targeting is of particular interest to researchers, as it presents as a personalized medicine approach in cancer cell metabolism and survival. By specifically targeting mitochondria, targeted therapies can disrupt energy produ...
Lysosome-Mediated Targeted Protein Degradation: Emerging Chimeric Platforms for Extracellular and Intracellular Therapeutics [0.03%]
溶酶体介导的靶向蛋白质降解：新兴的嵌合平台在细胞内外疗法中的应用
Shayan Asadi,Mina Taheri-Torbati,Prashant Kesharwani et al.
Shayan Asadi et al.
Targeted protein degradation (TPD) is an emerging drug discovery approach aimed at enabling the selective removal of disease-associated proteins. While proteolysis-targeting chimeras (PROTACs) have advanced intracellular degradation via the...
Therapeutic Potential of Trolox and Its Synthetic Derivatives as Multifunctional Bioactive Molecules in Periodontal Disease Management [0.03%]
Trolox及其合成衍生物在牙周病管理中的多效活性分子的治疗潜力
Mohammad Amin Valipour,Elaheh Abdollahi,Abbas Yadegar et al.
Mohammad Amin Valipour et al.
Periodontal disease is a chronic inflammatory problem that has destructive effects on the tooth-supporting tissues. This disease affects a large portion of the population, influencing overall health and quality of life, and significant soci...