Mitochondrial Dysfunction in Inflammatory Skin Diseases: Mechanisms, Biomarkers, and Emerging Therapeutic Strategies [0.03%]
炎症性皮肤病中的线粒体功能障碍：机制、生物标志物和新兴治疗策略
Mei Li,Guowei Zhao,Guo-Wei Zhao et al.
Mei Li et al.
Mitochondrial dysfunction critically underpins the pathogenesis of inflammatory skin diseases such as psoriasis, vitiligo, atopic dermatitis, and impaired wound healing. This comprehensive review synthesizes recent evidence to elucidate mec...
Protective Effects of Herbacetin in Experimental Colitis: Targeting NF-κB and NLRP3 Pathways [0.03%]
染料木素通过靶向NF-κB和NLRP3途径对实验性结肠炎的保护作用
Yousra Bseiso,Badriyah S Alotaibi,Alaa A A Aljabali et al.
Yousra Bseiso et al.
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) resulting from a dysregulation of immune responses. Herbacetin, a flavonoid of natural origin, has been found to exert an anti-inflammatory action, though its actions in ...
Polydatin Protects Against the Formation of PPE-Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear Factor Erythroid 2-Related Factor 2 [0.03%]
聚茋酸酯通过激活核因子E2相关因子2保护小鼠免受PPE诱导的腹主动脉瘤形成
Zikang Liu,Jinyi Zhu,Qian Zhou et al.
Zikang Liu et al.
Sudden death resulting from abdominal aortic aneurysm (AAA) rupture is a highly fatal cardiovascular condition. There remains an urgent need to identify innovative therapeutic strategies capable of decelerating AAA progression and rupture. ...
Overcoming Resistance in EGFR-Mutant Cancers: A Comprehensive Review of Inhibitor Evolution and SAR-Based Design [0.03%]
克服EGFR突变型癌症的耐药性：抑制剂进化和基于药物作用机制设计的全面回顾
Hemlata Naykwadi,Rajasekhar Reddy Alavala
Hemlata Naykwadi
The epidermal growth factor receptor (EGFR) is a key target in cancer therapy, mainly in non-small cell lung cancer (NSCLC). Though, the efficacy of EGFR-targeted therapies is limited by the development of resistance. This comprehensive rev...
Novel 4-chlorophenyl and 3/4-chlorophenoxy Based Triazole/Thiazole Derivatives: Synthesis and Investigation of Their Effects on Neurodegenerative Disorders-Related Enzymes via In Vitro and In Silico [0.03%]
基于新型对氯苯基和3/4-氯苯氧基三唑/噻唑衍生物的合成及其体内外实验与计算机模拟研究其对神经退行性疾病相关酶的影响
Sam Dawbaa,Demokrat Nuha,Asaf Evrim Evren et al.
Sam Dawbaa et al.
In this study, nine new synthesized compounds were investigated for their enzyme inhibition activity and evaluated for their ADME parameters and DFT-based properties. The compounds were classified into two main structures: derivatives of 2-...
3-Substituted Triazolone-Benzoate Hybrids: Synthesis, Enzyme Inhibition, Anticancer Activity and ADMET Evaluation by Molecular Docking and Dynamics Studies [0.03%]
3-取代三唑酮苯甲酸杂化物：合成，酶抑制作用，抗癌症活性及由分子对接和动力学研究进行的ADMET评价
Murat Beytur,Elif Tarmaşır,Ercan Oguz et al.
Murat Beytur et al.
In this study, eight 3-substitued -4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one compounds were synthesized. The reactions of these compounds with 2-ethoxy-4-formylphenyl benzoate, which was synthesized by the reaction of 3-ethoxy-4-hydroxy be...
Multitargeted Anti-Inflammatory Agents: Novel Pyrazole and Pyrazolo[1,5-a]Pyrimidine Carbonic Anhydrase and COX-2 Inhibitors With Optimal In Vivo Efficacy and Low Toxicity [0.03%]
多靶标抗炎药物：新型吡唑和吡唑并[1,5-a]嘧啶碳酸酐酶和COX-2抑制剂，具有最优的体内疗效和较低毒性
Mariam M Fakhry,Mohamed A Said,Andrea Ammara et al.
Mariam M Fakhry et al.
In this study, three series of pyrazole and pyrazolo[1,5-a]pyrimidine derivatives 6a-f, 8a-f, and 10a-f were designed and synthesized in response to the global need to safe and potent anti-inflammatory agents. A rational design strategy was...
Discovery of 1-(arylacetyl)-2-phenyl-pyrrolidine Derivatives as Novel POLθ-pol Inhibitors via Structure-Based Virtual Screening and Fragment Fusion [0.03%]
基于结构的虚拟筛选和片段融合发现新型POLθ聚合酶抑制剂1-（芳基乙酰基）-2-苯基吡咯烷衍生物
Wenlin Fan,Mengyuan Qiu,Zhenwei Wang et al.
Wenlin Fan et al.
DNA polymerase theta (POLθ) has been regarded as a promising therapeutic target for the treatment of BRCA-deficient tumors. In this study, 1-(arylacetyl)-2-phenyl-pyrrolidine derivative VS-13 was identified as a POLθ-pol inhibitor hit wit...
Lansbermin-I: A Snake Venom Disintegrin With Selective Cytotoxicity and Anti-Adhesive Effects Against Glioblastoma Cells [0.03%]
兰斯伯明-I：一种对胶质母细胞瘤细胞具有选择性细胞毒性和粘附抑制作用的蛇毒离整合素
Javier Orozco-Mera,Alejandro Montoya-Gómez,María José Sevilla-Sánchez et al.
Javier Orozco-Mera et al.
Glioblastoma is the most common and aggressive malignant brain tumor, characterized by poor response to current therapies and inevitable recurrence. Novel therapeutic strategies are urgently needed. Lansbermin-I, a disintegrin isolated from...
Mathematical and Artificial Intelligence Techniques in Modern Drug Discovery: A Review [0.03%]
现代药物发现中的数学和人工智能技术：综述
Akansha Agrwal,Rohit Kumar,Swati Maheshwari et al.
Akansha Agrwal et al.
The future of drug research is intrinsically connected to the continuous advancement and prudent integration of Artificial intelligence (AI) and mathematics. By addressing challenges and leveraging possibilities, the pharmaceutical industry...