Bulk Microarray and Single-Cell Transcriptomic Analyses Reveal Bacterial Lipopolysaccharide-Related Biomarkers in Sepsis [0.03%]
基于大规模基因芯片和单细胞转录组分析的脓毒症候选生物标志物筛选及验证研究
Haili Zhang,Xiaoying Wu,Lixue Wu et al.
Haili Zhang et al.
Sepsis, a life-threatening condition triggered by dysregulated host response to infection, poses significant global health challenges. Identifying lipopolysaccharide (LPS)-related biomarkers and underlying mechanisms remains critical, yet u...
AAV9-Delivered α7nAChR Ameliorates DSS-Induced Murine Ulcerative Colitis by Activating CAP Pathway, Inhibiting NF-κB/NLRP3 Axis and Restoring Intestinal Barrier and T-reg/Th-17 Homeostasis [0.03%]
AAV9递送的α7nAChR通过激活CAP通路、抑制NF-κB / NLRP3轴和恢复肠道屏障及T-reg / Th-17稳态来改善DSS诱导的小鼠溃疡性结肠炎
Rui Zhang,Qincheng Yang,Huimin Bi
Rui Zhang
This study aimed to explore the therapeutic effect and underlying mechanism of α7 nicotinic acetylcholine receptor (α7nAChR) mediated by adeno-associated virus serotype 9 (AAV9) on dextran sulfate sodium (DSS)-induced ulcerative colitis (...
Potent Multi-Target Inhibition of Cholinesterases and Carbonic Anhydrases by Iridium(III)-Phenanthroline Derivatives: Integrated Structure-Activity Relationship, Molecular Docking and Anticancer Cell Culture Studies [0.03%]
三价铱-菲咯啉衍生物同时抑制乙酰胆碱酯酶和碳酸酐酶的多靶点活性：整合构效关系、分子对接及抗肿瘤细胞培养研究
Zeynep Köksal,Kevser Kübra Kırboğa,Fatma Sağır et al.
Zeynep Köksal et al.
In this study, a series of novel iridium(III) complexes incorporating 2-phenylimidazo[4,5-f][1,10]phenanthroline ligands with different substituents (methyl (1a), isopropyl (2a), methoxy (3a), phenyl (4a)) were evaluated for their in vitro ...
Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues [0.03%]
隐花碱和2，7-二溴隐花碱的抗疟活性及药代动力学研究为设计新型抗疟药物奠定了基础
Elodie Chenu,James Duffy,Arnold Donkor Forkuo et al.
Elodie Chenu et al.
The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns r...
Artificial Intelligence in Drug Discovery: Integrative Advances From Data to Therapeutic Innovation [0.03%]
从数据到治疗创新：药物发现领域的整合人工智能进展
Mohammad Javad Mehran,Sara Mohammadzadeh,Mansoor Bolideei et al.
Mohammad Javad Mehran et al.
Integrating artificial intelligence (AI) into drug discovery revolutionizes pharmaceutical research by significantly accelerating the identification, optimization, and development of novel therapeutics. Conventional drug discovery methods, ...
Dynorphin A Inhibits the Proliferation, Migration, Invasion, and Stemness of Triple Negative Breast Cancer Cells [0.03%]
Dynorphin A抑制三阴性乳腺癌细胞的增殖、迁移、侵袭和干细胞特性
Xiaojiao Liu,Bo Chen,Xin Dong et al.
Xiaojiao Liu et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype that is characterized by a high metastatic capacity, limited therapeutic options, and a poor prognosis, largely because of its stemness properties and aberrant signaling. Dynorph...
Halting Tuberculosis in Its Tracks: Advances and Strategies for Discovering Therapeutic Targets in Mycobacterium tuberculosis [0.03%]
结核杆菌治疗靶点的发现策略与进展：制止结核病蔓延
Ayushi Sharma,Gyanendra Singh,Rahul Shrivastava
Ayushi Sharma
Tuberculosis is a global emergency. Despite two decades of intense research to understand and cure the disease, biological uncertainties prevail and hamper the therapeutic progress. Increasing incidences of multidrug-resistant (MDR) and ext...
Ferroptosis in Cholangiocarcinoma Therapy: Molecular Mechanisms, Pharmacological Modulation and Opportunities for Drug Development [0.03%]
胆管癌治疗中铁死亡的分子机制、药理学调控及药物开发机遇
Hafsa Athar,Sabahat Zulfiqar,Arslan Ali et al.
Hafsa Athar et al.
Cholangiocarcinoma (CCA) is a type of cancer that has a rather high mortality rate and arises from cholangiocytes. Due to its aggressive nature, CCA is considered a rare and highly advanced form of malignancy. This research is detailed arou...
Reprogramming the Tumor Microenvironment: Calebin A as a Polyphenolic Paradigm Shift in Controlling Inflammation, Stemness, and Resistance in Colorectal Cancer [0.03%]
肿瘤微环境的再编程：Calebin A 作为结直肠癌控制炎症、干细胞和耐药性的多酚范例转变
Abdullah A Alshehri,Wael Y Khawagi
Abdullah A Alshehri
Colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, largely due to inflammation-driven progression, cancer stemness, and multidrug resistance (MDR). The tumor microenvironment (TME) orchestrates these hallmarks th...