DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss [0.03%]
DPP4驱动的铁死亡促进衰老：姜黄素作为治疗年龄相关性骨质流失的药物
Hongming Zhou,Xiaoxi Liu,Hengren Li et al.
Hongming Zhou et al.
Senile osteoporosis is driven by bone marrow stromal cell (BMSC) senescence. Ferroptosis, an iron-dependent cell death pathway, is implicated in aging. The natural flavonoid galangin possesses anti-aging properties, yet its effects on ferro...
Secoisolariciresinol Diglucoside Alleviates LPS-Induced Acute Lung Injury by Inhibiting the NF-κB/NLRP3 Signaling Pathway [0.03%]
セコイソラクリシロside glucoside通过抑制NF-κB / NLRP3信号通路缓解LPS诱导的急性肺损伤
Yuanyuan Zhong,Yang Zou,Zhen Qu et al.
Yuanyuan Zhong et al.
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening pulmonary disorders with high mortality rates, and effective treatments are currently lacking. Secoisolariciresinol diglucosi...
PKCδ-Drp1 Axis Mediates VIP-Induced Mitochondrial Fragmentation and Metabolic Crisis in Nasopharyngeal Carcinoma [0.03%]
VIP诱导的鼻咽癌细胞线粒体碎裂及代谢危机中的PKCδ-Drp1轴介导作用
Jingda Xu,Guanzheng Wu,Min Chen et al.
Jingda Xu et al.
In nasopharyngeal carcinoma, mitochondria often function abnormally. However, the precise signals that cause excessive mitochondrial division are still undefined. Levels of the neuropeptide Vasoactive Intestinal Peptide are altered in NPC t...
Artificial Intelligence in Drug Discovery and Development: Transforming Pharmaceutical Innovation [0.03%]
人工智能在药物发现和开发中的应用：转化制药创新
Mohd Shoab Ali,Taha Alqahtani,Humood Al Shmrany et al.
Mohd Shoab Ali et al.
Drug discovery remains a lengthy, costly, and high-risk endeavor, often requiring over a decade from target identification to clinical translation. Artificial intelligence (AI) is reshaping this paradigm by enabling more efficient and accur...
Targeting Alpha-Synuclein Aggregation With Chemical Chaperone IP-045: An Approach to Parkinson's Disease Therapy [0.03%]
靶向多巴氏症治疗的化学伴侣IP-045：抑制索因蛋白聚合疗法
Navpreet Kaur,Rimaljot Singh,Neelima Dhingra et al.
Navpreet Kaur et al.
Protein misfolding and aggregation of alpha-synuclein (α-syn) are central to Parkinson's disease (PD). Current therapies provide only symptomatic relief without addressing α-syn aggregation. Chemical chaperones such as 4-phenylbutyrate (4...
Cryptocaryone Exhibits ROS/MAPK-Dependent Antiproliferative and Apoptosis-Inducing Effects on Triple-Negative Breast Cancer Cells and Proof-of-Concept Breast Cancer Mouse Model [0.03%]
基于ROS / MAPK依赖的反增殖和诱导凋亡作用的肉桂酮对三阴性乳腺癌细胞及概念验证的乳腺癌小鼠模型的作用研究
Ya-Ting Chuang,Wangta Liu,Tsu-Ming Chien et al.
Ya-Ting Chuang et al.
Omics' technologies have enabled clinicians to gain previously unprecedented insights into the molecular complexity and clinical heterogeneity of triple-negative breast cancer (TNBC). Increasingly it is being realized that TNBC does not res...
Cyclophosphamide Induces Autophagy-Dependent Ferroptosis Through Promoting ETNK1 Expression in Breast Cancer Cells [0.03%]
环磷酰胺通过促进ETNK1表达在乳腺癌细胞中诱导依赖自噬的铁死亡
Jiacheng Shen,Aifeng Qiu,Xiaobing Liu et al.
Jiacheng Shen et al.
Breast cancer is the most common cancer in females worldwide, and the incidence rate in China has been increasing in recent decades. The treatment of breast cancer with cyclophosphamide (CTX) is one of the cornerstones of combination chemot...
Preparation of Aaptamine-Loaded Fusogenic Liposomes and Evaluation of Its Enhanced Antibacterial Activity Against MRSA [0.03%]
包合有aaptamine的融合型脂质体的制备及其对MRSA抗菌活性的研究
Tianjiao Geng,Guoqiang Hou,Yingqiu Liu et al.
Tianjiao Geng et al.
The global threat of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the development of novel therapeutic strategies. Our previous work identified A7, a marine-derived aaptamine alkaloid, as a potential anti-MRSA agent. Howe...
Targeting the NLRP3 Inflammasome: Novel Inhibitors for Cardiovascular Diseases Management - A Narrative Review [0.03%]
针对NLRP3炎症小体的靶向作用：心血管疾病管理的新抑制剂——叙述性综述
Yomna S Momen
Yomna S Momen
The innate immune system is the first line of defense against pathogens and intracellular danger signals, providing a rapid nonspecific response to eliminate the infection and maintain tissue homeostasis. NLRP3 (NLR family pyrin domain cont...
Ferrocene-Pyrazole Hybrid Induces Ferroptosis and Metabolic Disruption in Pancreatic Cancer [0.03%]
铁焦宁-吡唑杂化物诱导胰腺癌细胞的铁死亡和代谢紊乱
Kuan Liu,Junhao Dai,Jianhua Wei et al.
Kuan Liu et al.
Drugs with multiple anticancer mechanisms have shown promising applications in tumor treatment. Herein, we synthesized a series of ferrocene-pyrazole hybrids (8-11) to assess their anti-pancreatic cancer activities. Among them, compound 11 ...