Rational Design and Characterization of 5-Fluorouracil-Loaded Lipid-Polymer Hybrid Nanoparticles for Enhanced Transdermal Delivery in Skin Cancer Therapy [0.03%]
用于皮肤癌治疗的5-氟尿嘧啶载脂质聚合物杂化纳米粒的合理设计及表征
Tenzin Sonam Dongsar,Taha Alqahtani,Humood Al Shmrany et al.
Tenzin Sonam Dongsar et al.
Effective management of skin cancer remains challenging due to limited transdermal drug penetration, systemic toxicity, and therapeutic resistance. In this study, 5-fluorouracil (5-FU)-loaded lipid-polymer hybrid nanoparticles (LPHNPs) were...
Piperidine-Based Hydrazones and Their Pt(II)/Pd(II) Complexes: Synthesis, Structural Characterization, In Vitro Anticancer Evaluation, and In Silico Studies [0.03%]
基于パイペリジン的腙及其Pt(II)/Pd(II)配合物：合成，结构表征，体外抗癌评价和计算机辅助药物设计研究
Muhammed Oğuzhan Doğan,Emine Elçin Oruç-Emre,İbrahim Tahsin Alyamaç et al.
Muhammed Oğuzhan Doğan et al.
In this study, 2-(4-methylpiperidin-1-yl)acetohydrazide was condensed with a series of substituted benzaldehydes to afford a library of piperidine-based hydrazones, which were subsequently complexed with K₂PtCl₄ and K₂PdCl₄ to yield the...
Design and Synthesis of Novel Lonidamine-N-Heterocyclic Derivatives With Potent Anticancer Activity Against Colorectal Cancer Cells [0.03%]
新型Lonidamine-N杂环衍生物的设计合成及其抗结直肠癌活性研究
Raveendra Madhukar Bhat,Priyadarshini An,Gangadhar V Muddapur et al.
Raveendra Madhukar Bhat et al.
Colorectal cancer remains a major health concern and the second leading cause of cancer deaths, underscoring the urgent need for advanced early diagnostic methods to improve survival outcomes. In this study, we designed and synthesized a ne...
Karthik Shree Harini,Devaraj Ezhilarasan
Karthik Shree Harini
The conventional drug discovery pipeline is labour-intensive, time-consuming, and costly, involving target identification, hit discovery, lead optimization, and extensive preclinical and clinical evaluation. To overcome these limitations, a...
Novel Imidazoquinoline Based TLR7 Agonist Induces Antileishmanial Efficacy-An In Vitro Study [0.03%]
新型基于咪唑喹啉的TLR7激动剂抗利什曼原虫疗效的体外研究
Shivani Thakur,Kushvinder Kumar,Sandeep Kaur et al.
Shivani Thakur et al.
Leishmaniasis elimination and control remain challenging due to the lack of successful treatment and possible prevention. A suitable anti-leishmanial medication that is acceptable in terms of price and safety is currently being researched. ...
Structural Exploration of Pyrazine-1,2,3-Triazole Hybrids as Selective Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease [0.03%]
用于治疗阿尔茨海默病的乙酰胆碱酯酶抑制剂吡嗪并三氮唑类衍生物的结构研究
Madala Ramesh,Pannala Padmaja,Vinod Ugale et al.
Madala Ramesh et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to gradual deterioration of cognitive functions. Cholinesterase enzymes play a critical role in regulating acetylcholine levels in the brain, and their dysfunct...
Discovery of Novel 1,3,5-trisubstituted-2-thioxo-imidazole Derivatives as Potential Aromatase Inhibitors: Design, Synthesis, In Vitro Anti-Breast Cancer Screening and Molecular Docking Studies [0.03%]
作为潜在芳香酶抑制剂的新型1,3,5-三取代-2-硫代咪唑衍生物的发现：设计，合成，体外抗乳腺癌筛选及分子对接研究
Mohamed F Youssef,Jehan A Hasanen,Alaa A Shehata et al.
Mohamed F Youssef et al.
Imidazole derivatives have a multi-targeted ability that indicates their ability to act as anticancer agents in respect to breast cancer. This study aimed to evaluate the anticancer response of a new series of 1, 3, 5-trisubstituted-2-thiox...
Innovative Drug and Prodrug Candidates in Cancer Treatment Targeting TP53 Mutations: Challenge and Hope [0.03%]
针对TP53突变的抗癌创新药物和前药候选物：挑战与希望
Raed M Al-Zoubi,Mai Elaarag,Ayman A Zarour et al.
Raed M Al-Zoubi et al.
The TP53 gene encodes the tumor suppressor protein 53, which is critical for maintaining genomic stability and preventing tumorigenesis. Mutations in TP53, particularly missense mutations, have a substantial impact on cancer progression bec...
Azole Amide Analogues as Antibacterial Agents Against Methicillin-Resistant Staphylococcus aureus and Its Structure-Activity Relationship Studies [0.03%]
抗耐甲氧西林金黄色葡萄球菌的azole酰胺衍生物及其活性与结构关系研究
Saraswati Sharma,Rameshwari Verma,Santosh Kumar Verma et al.
Saraswati Sharma et al.
Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known cause of serious skin and soft tissue infections, representing a significant global public health threat. The rapid development of MRSA resistance to all known antibiotics i...
Dehydrocorydaline in Corydalis Yanhusuo Promotes M2 Microglial Polarization and Alleviates Neuroinflammation After Cerebral Ischemia-Reperfusion Injury by Inhibiting the JAK1/STAT3 Pathway [0.03%]
延胡索中去氢延胡索甲素通过抑制JAK1/STAT3信号通路促进M2型小胶质细胞极化从而改善脑缺血再灌注后神经炎症损伤
Lu Wei,Yanli Yu,Liwen Hu et al.
Lu Wei et al.
Ischemic stroke is the third leading cause of death and disability worldwide. Cerebral ischemia-reperfusion injury leads to severe neuroinflammation, in which microglial polarization plays a key role. Dehydrocorydaline (DHC), the main alkal...